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Items: 1 to 20 of 30

1.

Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling.

Moloney AM, Griffin RJ, Timmons S, O'Connor R, Ravid R, O'Neill C.

Neurobiol Aging. 2010 Feb;31(2):224-43. doi: 10.1016/j.neurobiolaging.2008.04.002. Epub .

PMID:
18479783
2.
3.

Genetic engineering in mice: impact on insulin signalling and action.

Lamothe B, Baudry A, Desbois P, Lamotte L, Bucchini D, De Meyts P, Joshi RL.

Biochem J. 1998 Oct 15;335 ( Pt 2):193-204. Review.

4.

Central insulin and insulin-like growth factor-1 signaling: implications for diabetes associated dementia.

Zemva J, Schubert M.

Curr Diabetes Rev. 2011 Sep;7(5):356-66. Review.

PMID:
21916834
5.
6.

Signal transduction mechanism of insulin and insulin-like growth factor-1.

Kadowaki T, Tobe K, Honda-Yamamoto R, Tamemoto H, Kaburagi Y, Momomura K, Ueki K, Takahashi Y, Yamauchi T, Akanuma Y, Yazaki Y.

Endocr J. 1996 Oct;43 Suppl:S33-41. Review.

7.

Insulin and IGF-1 signalling: longevity, protein homoeostasis and Alzheimer's disease.

O'Neill C, Kiely AP, Coakley MF, Manning S, Long-Smith CM.

Biochem Soc Trans. 2012 Aug;40(4):721-7. doi: 10.1042/BST20120080. Review.

PMID:
22817723
8.

Targeting the type I insulin-like growth factor system for breast cancer therapy.

Sachdev D.

Curr Drug Targets. 2010 Sep;11(9):1121-32. Review.

PMID:
20545608
9.

The insulin receptor substrate (IRS) proteins: at the intersection of metabolism and cancer.

Shaw LM.

Cell Cycle. 2011 Jun 1;10(11):1750-6. Epub 2011 Jun 1. Review.

10.

Possible usefulness of growth hormone/insulin-like growth factor-I axis in Alzheimer's disease treatment.

Sáez JM.

Endocr Metab Immune Disord Drug Targets. 2012 Sep;12(3):274-86. Review.

PMID:
22524398
11.

Small molecule inhibitors of the IGF-1R/IR axis for the treatment of cancer.

Buck E, Mulvihill M.

Expert Opin Investig Drugs. 2011 May;20(5):605-21. doi: 10.1517/13543784.2011.558501. Epub 2011 Mar 30. Review.

PMID:
21446886
12.

Small-molecule ATP-competitive dual IGF-1R and insulin receptor inhibitors: structural insights, chemical diversity and molecular evolution.

Jin M, Wang J, Buck E, Mulvihill MJ.

Future Med Chem. 2012 Mar;4(3):315-28. doi: 10.4155/fmc.11.180. Review.

PMID:
22393939
13.

From signal transduction to signal interpretation: an alternative model for the molecular function of insulin receptor substrates.

Boller S, Joblin BA, Xu L, Item F, Trüb T, Boschetti N, Spinas GA, Niessen M.

Arch Physiol Biochem. 2012 Jul;118(3):148-55. doi: 10.3109/13813455.2012.671333. Epub 2012 Apr 20. Review.

PMID:
22515179
14.

The impairment of insulin signaling in Alzheimer's disease.

Candeias E, Duarte AI, Carvalho C, Correia SC, Cardoso S, Santos RX, Plácido AI, Perry G, Moreira PI.

IUBMB Life. 2012 Dec;64(12):951-7. doi: 10.1002/iub.1098. Epub 2012 Nov 6. Review.

15.

IGF-I receptor signalling in transformation and differentiation.

Valentinis B, Baserga R.

Mol Pathol. 2001 Jun;54(3):133-7. Review.

16.

Nuclear IRS-1 and cancer.

Reiss K, Del Valle L, Lassak A, Trojanek J.

J Cell Physiol. 2012 Aug;227(8):2992-3000. doi: 10.1002/jcp.24019. Review.

17.

The IGF-1 receptor and regulation of nitric oxide bioavailability and insulin signalling in the endothelium.

Gatenby VK, Imrie H, Kearney M.

Pflugers Arch. 2013 Aug;465(8):1065-74. doi: 10.1007/s00424-013-1218-z. Epub 2013 Jan 22. Review.

PMID:
23338941
18.

New roles for insulin-like hormones in neuronal signalling and protection: new hopes for novel treatments of Alzheimer's disease?

Hölscher C, Li L.

Neurobiol Aging. 2010 Sep;31(9):1495-502. doi: 10.1016/j.neurobiolaging.2008.08.023. Epub 2008 Oct 18. Review.

PMID:
18930564
19.

Possible implications of insulin resistance and glucose metabolism in Alzheimer's disease pathogenesis.

Bosco D, Fava A, Plastino M, Montalcini T, Pujia A.

J Cell Mol Med. 2011 Sep;15(9):1807-21. doi: 10.1111/j.1582-4934.2011.01318.x. Review.

20.

Potential roles of insulin and IGF-1 in Alzheimer's disease.

Gasparini L, Xu H.

Trends Neurosci. 2003 Aug;26(8):404-6. Review.

PMID:
12900169
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