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Results: 1 to 20 of 34

1.

LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity.

Jaleel M, Nichols RJ, Deak M, Campbell DG, Gillardon F, Knebel A, Alessi DR.

Biochem J. 2007 Jul 15;405(2):307-17.

PMID:
17447891
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Is inhibition of kinase activity the only therapeutic strategy for LRRK2-associated Parkinson's disease?

Rudenko IN, Chia R, Cookson MR.

BMC Med. 2012 Feb 23;10:20. doi: 10.1186/1741-7015-10-20. Review.

PMID:
22361010
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Molecular biology changes associated with LRRK2 mutations in Parkinson's disease.

Lu YW, Tan EK.

J Neurosci Res. 2008 Jul;86(9):1895-901. doi: 10.1002/jnr.21656. Review.

PMID:
18338801
[PubMed - indexed for MEDLINE]
4.

Leucine-rich repeat kinase 2: relevance to Parkinson's disease.

Guo L, Wang W, Chen SG.

Int J Biochem Cell Biol. 2006;38(9):1469-75. Epub 2006 Mar 2. Review.

PMID:
16600664
[PubMed - indexed for MEDLINE]
5.

The GTPase function of LRRK2.

Taymans JM.

Biochem Soc Trans. 2012 Oct;40(5):1063-9. Review.

PMID:
22988866
[PubMed - indexed for MEDLINE]
6.

Leucine-rich repeat kinase 2-linked Parkinson's disease: clinical and molecular findings.

Kumari U, Tan EK.

J Mov Disord. 2010 Oct;3(2):25-31. doi: 10.14802/jmd.10008. Epub 2010 Oct 30. Review.

PMID:
24868377
[PubMed]
Free PMC Article
7.

Contribution of GTPase activity to LRRK2-associated Parkinson disease.

Tsika E, Moore DJ.

Small GTPases. 2013 Jul-Sep;4(3):164-70. doi: 10.4161/sgtp.25130. Epub 2013 Jun 10. Review.

PMID:
24025585
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Clinical features of LRRK2 parkinsonism.

Haugarvoll K, Wszolek ZK.

Parkinsonism Relat Disord. 2009 Dec;15 Suppl 3:S205-8. doi: 10.1016/S1353-8020(09)70815-6. Review.

PMID:
20082991
[PubMed - indexed for MEDLINE]
9.

Analysis of LRRK2 accessory repeat domains: prediction of repeat length, number and sites of Parkinson's disease mutations.

Mills RD, Mulhern TD, Cheng HC, Culvenor JG.

Biochem Soc Trans. 2012 Oct;40(5):1086-9. Review.

PMID:
22988870
[PubMed - indexed for MEDLINE]
10.

Role of LRRK2 kinase activity in the pathogenesis of Parkinson's disease.

Greggio E.

Biochem Soc Trans. 2012 Oct;40(5):1058-62. Review.

PMID:
22988865
[PubMed - indexed for MEDLINE]
11.

Leucine-rich repeat kinase 2 (LRRK2): a key player in the pathogenesis of Parkinson's disease.

Gandhi PN, Chen SG, Wilson-Delfosse AL.

J Neurosci Res. 2009 May 1;87(6):1283-95. doi: 10.1002/jnr.21949. Review.

PMID:
19025767
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Biochemical and molecular features of LRRK2 and its pathophysiological roles in Parkinson's disease.

Seol W.

BMB Rep. 2010 Apr;43(4):233-44. Review.

PMID:
20423607
[PubMed - indexed for MEDLINE]
Free Article
13.

LRRK2 GTPase dysfunction in the pathogenesis of Parkinson's disease.

Xiong Y, Dawson VL, Dawson TM.

Biochem Soc Trans. 2012 Oct;40(5):1074-9. Review.

PMID:
22988868
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Leucine-rich repeat kinase 2 mutations and Parkinson's disease: three questions.

Greggio E, Cookson MR.

ASN Neuro. 2009 Apr 14;1(1). pii: e00002. doi: 10.1042/AN20090007. Review.

PMID:
19570025
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

LRRK2 in Parkinson's disease: genetic and clinical studies from patients.

Kumari U, Tan EK.

FEBS J. 2009 Nov;276(22):6455-63. doi: 10.1111/j.1742-4658.2009.07344.x. Epub 2009 Oct 5. Review.

PMID:
19804413
[PubMed - indexed for MEDLINE]
16.

Leucine-rich repeat kinase 2 (LRRK2) cellular biology: a review of recent advances in identifying physiological substrates and cellular functions.

Drolet RE, Sanders JM, Kern JT.

J Neurogenet. 2011 Dec;25(4):140-51. doi: 10.3109/01677063.2011.627072. Epub 2011 Nov 11. Review.

PMID:
22077787
[PubMed - indexed for MEDLINE]
17.

LRRK2 in Parkinson's disease: function in cells and neurodegeneration.

Webber PJ, West AB.

FEBS J. 2009 Nov;276(22):6436-44. doi: 10.1111/j.1742-4658.2009.07342.x. Epub 2009 Oct 5. Review.

PMID:
19804415
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Small molecule kinase inhibitors for LRRK2 and their application to Parkinson's disease models.

Kramer T, Lo Monte F, Göring S, Okala Amombo GM, Schmidt B.

ACS Chem Neurosci. 2012 Mar 21;3(3):151-60. doi: 10.1021/cn200117j. Epub 2012 Jan 18. Review.

PMID:
22860184
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

LRRK2 in Parkinson's disease: biochemical functions.

Anand VS, Braithwaite SP.

FEBS J. 2009 Nov;276(22):6428-35. doi: 10.1111/j.1742-4658.2009.07341.x. Epub 2009 Oct 5. Review.

PMID:
19804416
[PubMed - indexed for MEDLINE]
20.

The biology and pathobiology of LRRK2: implications for Parkinson's disease.

Moore DJ.

Parkinsonism Relat Disord. 2008;14 Suppl 2:S92-8. doi: 10.1016/j.parkreldis.2008.04.010. Epub 2008 Jul 7. Review.

PMID:
18602856
[PubMed - indexed for MEDLINE]

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