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Nat Neurosci. 2006 Nov;9(11):1362-3. Epub 2006 Oct 1.

Capacity for 5-HT1A-mediated autoregulation predicts amygdala reactivity.

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  • 1Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA.

Erratum in

  • Nat Neurosci. 2007 Feb;10(2):263. Moses-Kolko, E L [added]; Berga, S L [added].


We examined the contribution of 5-HT1A autoreceptors (with [11C]WAY100635 positron emission tomography) to amygdala reactivity (with blood oxygenation level-dependent functional magnetic resonance imaging) in 20 healthy adult volunteers. We found a significant inverse relationship wherein 5-HT1A autoreceptor density predicted a notable 30-44% of the variability in amygdala reactivity. Our data suggest a potential molecular mechanism by which a reduced capacity for negative feedback regulation of 5-HT release is associated with increased amygdala reactivity.

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