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Results: 1 to 20 of 124

1.

The anxioselective agent 7-(2-chloropyridin-4-yl)pyrazolo-[1,5-a]-pyrimidin-3-yl](pyridin-2-yl)methanone (DOV 51892) is more efficacious than diazepam at enhancing GABA-gated currents at alpha1 subunit-containing GABAA receptors.

Popik P, Kostakis E, Krawczyk M, Nowak G, Szewczyk B, Krieter P, Chen Z, Russek SJ, Gibbs TT, Farb DH, Skolnick P, Lippa AS, Basile AS.

J Pharmacol Exp Ther. 2006 Dec;319(3):1244-52. Epub 2006 Sep 13.

PMID:
16971504
[PubMed - indexed for MEDLINE]
Free Article
2.

GABAA receptor subtype-selective modulators. I. α2/α3-selective agonists as non-sedating anxiolytics.

Atack JR.

Curr Top Med Chem. 2011;11(9):1176-202. Review.

PMID:
21050172
[PubMed - indexed for MEDLINE]
3.

Anxioselective compounds acting at the GABA(A) receptor benzodiazepine binding site.

Atack JR.

Curr Drug Targets CNS Neurol Disord. 2003 Aug;2(4):213-32. Review.

PMID:
12871032
[PubMed - indexed for MEDLINE]
4.

SL651498, a GABAA receptor agonist with subtype-selective efficacy, as a potential treatment for generalized anxiety disorder and muscle spasms.

Griebel G, Perrault G, Simiand J, Cohen C, Granger P, Depoortere H, Françon D, Avenet P, Schoemaker H, Evanno Y, Sevrin M, George P, Scatton B.

CNS Drug Rev. 2003 Spring;9(1):3-20. Review.

PMID:
12595909
[PubMed - indexed for MEDLINE]
5.

Pharmacology of the pyrazolo-type compounds: agonist, antagonist and inverse agonist actions.

Bennett DA.

Physiol Behav. 1987;41(3):241-5. Review.

PMID:
2893398
[PubMed - indexed for MEDLINE]
6.

The benzodiazepine binding site of GABA(A) receptors as a target for the development of novel anxiolytics.

Atack JR.

Expert Opin Investig Drugs. 2005 May;14(5):601-18. Review.

PMID:
15926867
[PubMed - indexed for MEDLINE]
7.

Regulation of GABAA receptor structure and function by chronic drug treatments in vivo and with stably transfected cells.

Klein RL, Harris RA.

Jpn J Pharmacol. 1996 Jan;70(1):1-15. Review.

PMID:
8822084
[PubMed - indexed for MEDLINE]
Free Article
8.

GABAergic dysfunction in schizophrenia: new treatment strategies on the horizon.

Guidotti A, Auta J, Davis JM, Dong E, Grayson DR, Veldic M, Zhang X, Costa E.

Psychopharmacology (Berl). 2005 Jul;180(2):191-205. Epub 2005 Apr 28. Review.

PMID:
15864560
[PubMed - indexed for MEDLINE]
9.

The diversity of GABAA receptors. Pharmacological and electrophysiological properties of GABAA channel subtypes.

Hevers W, Lüddens H.

Mol Neurobiol. 1998 Aug;18(1):35-86. Review.

PMID:
9824848
[PubMed - indexed for MEDLINE]
10.

The GABAA-BZR complex as target for the development of anxiolytic drugs.

Trincavelli ML, Da Pozzo E, Daniele S, Martini C.

Curr Top Med Chem. 2012;12(4):254-69. Review.

PMID:
22204488
[PubMed - indexed for MEDLINE]
11.

New insights into the mechanism of action of hypnotics.

Doble A.

J Psychopharmacol. 1999;13(4 Suppl 1):S11-20. Review.

PMID:
10667451
[PubMed - indexed for MEDLINE]
12.

GABA(A) receptor physiology and its relationship to the mechanism of action of the 1,5-benzodiazepine clobazam.

Sankar R.

CNS Drugs. 2012 Mar 1;26(3):229-44. doi: 10.2165/11599020-000000000-00000. Review.

PMID:
22145708
[PubMed - indexed for MEDLINE]
13.

Novel non-benzodiazepine anxiolytics.

Goldberg ME, Salama AI, Patel JB, Malick JB.

Neuropharmacology. 1983 Dec;22(12B):1499-504. Review.

PMID:
6142427
[PubMed - indexed for MEDLINE]
14.

What can be learned from the effects of benzodiazepines on exploratory behavior?

File SE.

Neurosci Biobehav Rev. 1985 Spring;9(1):45-54. Review.

PMID:
2858081
[PubMed - indexed for MEDLINE]
15.

Behavioral effects of GABA agonists in relation to anxiety and benzodiazepine action.

Shephard RA.

Life Sci. 1987 Jun 22;40(25):2429-36. Review.

PMID:
2884549
[PubMed - indexed for MEDLINE]
16.

Treating insomnia: Current and investigational pharmacological approaches.

Ebert B, Wafford KA, Deacon S.

Pharmacol Ther. 2006 Dec;112(3):612-29. Epub 2006 Jul 28. Review.

PMID:
16876255
[PubMed - indexed for MEDLINE]
17.

Alpha subunit position and GABA receptor function.

Burt DR.

Sci STKE. 2005 Feb 8;2005(270):pe5. Review.

PMID:
15701893
[PubMed - indexed for MEDLINE]
18.

The possible involvement of GABA mechanisms in the action of benzodiazepines on central catecholamine neurons.

Fuxe K, Agnati LF, Bolme P, Hökfelt T, Lidbrink P, Ljungdahl A, Pérez de la Mora M, Ogren S.

Adv Biochem Psychopharmacol. 1975;(14):45-61. Review.

PMID:
242202
[PubMed - indexed for MEDLINE]
19.

Identification of molecular substrate for the attenuation of anxiety: a step toward the development of better anti-anxiety drugs.

Rudolph U.

ScientificWorldJournal. 2001 May 1;1:192-3. Review.

PMID:
12805666
[PubMed - indexed for MEDLINE]
Free Article
20.

Exploratory behavior models of anxiety in mice.

Crawley JN.

Neurosci Biobehav Rev. 1985 Spring;9(1):37-44. Review.

PMID:
2858080
[PubMed - indexed for MEDLINE]

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