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Related Articles by Review for PubMed (Select 15731261)


Long-term cytomegalovirus infection leads to significant changes in the composition of the CD8+ T-cell repertoire, which may be the basis for an imbalance in the cytokine production profile in elderly persons.

Almanzar G, Schwaiger S, Jenewein B, Keller M, Herndler-Brandstetter D, Würzner R, Schönitzer D, Grubeck-Loebenstein B.

J Virol. 2005 Mar;79(6):3675-83.


The immune system in extreme longevity.

Sansoni P, Vescovini R, Fagnoni F, Biasini C, Zanni F, Zanlari L, Telera A, Lucchini G, Passeri G, Monti D, Franceschi C, Passeri M.

Exp Gerontol. 2008 Feb;43(2):61-5. Epub 2007 Jul 4. Review.


T-cell biology in aging, with a focus on lung disease.

Lee N, Shin MS, Kang I.

J Gerontol A Biol Sci Med Sci. 2012 Mar;67(3):254-63. doi: 10.1093/gerona/glr237. Epub 2012 Mar 5. Review.


The narrowing of the CD8 T cell repertoire in old age.

Blackman MA, Woodland DL.

Curr Opin Immunol. 2011 Aug;23(4):537-42. doi: 10.1016/j.coi.2011.05.005. Epub 2011 Jun 7. Review.


T cell replicative senescence in human aging.

Chou JP, Effros RB.

Curr Pharm Des. 2013;19(9):1680-98. Review.


Aging of the T cell compartment in mice and humans: from no naive expectations to foggy memories.

Nikolich-Žugich J.

J Immunol. 2014 Sep 15;193(6):2622-9. doi: 10.4049/jimmunol.1401174. Review.


The unmet need in the elderly: how immunosenescence, CMV infection, co-morbidities and frailty are a challenge for the development of more effective influenza vaccines.

McElhaney JE, Zhou X, Talbot HK, Soethout E, Bleackley RC, Granville DJ, Pawelec G.

Vaccine. 2012 Mar 9;30(12):2060-7. doi: 10.1016/j.vaccine.2012.01.015. Epub 2012 Jan 27. Review.


Immunosenenescence: role of cytomegalovirus.

Pawelec G.

Exp Gerontol. 2014 Jun;54:1-5. doi: 10.1016/j.exger.2013.11.010. Epub 2013 Nov 28. Review.


Molecular basis for checkpoints in the CD8 T cell response: tolerance versus activation.

Mescher MF, Agarwal P, Casey KA, Hammerbeck CD, Xiao Z, Curtsinger JM.

Semin Immunol. 2007 Jun;19(3):153-61. Epub 2007 Mar 26. Review.


Age-related changes in CD8 T cell homeostasis and immunity to infection.

Nikolich-Žugich J, Li G, Uhrlaub JL, Renkema KR, Smithey MJ.

Semin Immunol. 2012 Oct;24(5):356-64. doi: 10.1016/j.smim.2012.04.009. Epub 2012 May 1. Review.


Properties of end-stage human T cells defined by CD45RA re-expression.

Henson SM, Riddell NE, Akbar AN.

Curr Opin Immunol. 2012 Aug;24(4):476-81. doi: 10.1016/j.coi.2012.04.001. Epub 2012 May 1. Review.


Ageing and life-long maintenance of T-cell subsets in the face of latent persistent infections.

Nikolich-Zugich J.

Nat Rev Immunol. 2008 Jul;8(7):512-22. doi: 10.1038/nri2318. Review.


Metabolic syndrome, hormones, and maintenance of T cells during aging.

Hsu HC, Mountz JD.

Curr Opin Immunol. 2010 Aug;22(4):541-8. doi: 10.1016/j.coi.2010.05.002. Epub 2010 Jun 28. Review.


Loss of renal function causes premature aging of the immune system.

Betjes MG, Meijers RW, Litjens NH.

Blood Purif. 2013;36(3-4):173-8. doi: 10.1159/000356084. Epub 2013 Dec 20. Review.


Immunologic changes in frail older adults.

Wang GC, Casolaro V.

Transl Med UniSa. 2014 Apr 24;9:1-6. eCollection 2014 Apr. Review.


Human T cell aging and the impact of persistent viral infections.

Fülöp T, Larbi A, Pawelec G.

Front Immunol. 2013 Sep 13;4:271. doi: 10.3389/fimmu.2013.00271. Review.

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