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Items: 1 to 20 of 21

1.

Chronic treatment with the gamma-secretase inhibitor LY-411,575 inhibits beta-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation.

Wong GT, Manfra D, Poulet FM, Zhang Q, Josien H, Bara T, Engstrom L, Pinzon-Ortiz M, Fine JS, Lee HJ, Zhang L, Higgins GA, Parker EM.

J Biol Chem. 2004 Mar 26;279(13):12876-82. Epub 2004 Jan 6.

2.
3.

Gamma-secretase inhibitors for Alzheimer's disease: balancing efficacy and toxicity.

Barten DM, Meredith JE Jr, Zaczek R, Houston JG, Albright CF.

Drugs R D. 2006;7(2):87-97. Review.

PMID:
16542055
4.

BACE1: the beta-secretase enzyme in Alzheimer's disease.

Vassar R.

J Mol Neurosci. 2004;23(1-2):105-14. Review.

PMID:
15126696
5.
6.

Therapeutic potential of gamma-secretase inhibitors and modulators.

Imbimbo BP.

Curr Top Med Chem. 2008;8(1):54-61. Review.

PMID:
18220933
7.

Secretase inhibitors for Alzheimer's disease: challenges of a promiscuous protease.

Pollack SJ, Lewis H.

Curr Opin Investig Drugs. 2005 Jan;6(1):35-47. Review.

PMID:
15675602
8.

γ-secretase inhibitors and modulators for the treatment of Alzheimer's disease: disappointments and hopes.

Imbimbo BP, Giardina GA.

Curr Top Med Chem. 2011;11(12):1555-70. Review.

PMID:
21510832
9.

beta-Secretase, APP and Abeta in Alzheimer's disease.

Vassar R.

Subcell Biochem. 2005;38:79-103. Review.

PMID:
15709474
10.

Uncovering gamma-secretase.

Steiner H.

Curr Alzheimer Res. 2004 Aug;1(3):175-81. Review.

PMID:
15975065
11.

Presenilin function and gamma-secretase activity.

Brunkan AL, Goate AM.

J Neurochem. 2005 May;93(4):769-92. Review.

12.
13.

Gamma-secretase: never more enigmatic.

Sisodia SS, Annaert W, Kim SH, De Strooper B.

Trends Neurosci. 2001 Nov;24(11 Suppl):S2-6. Review.

PMID:
11881741
14.

gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in?

Sisodia SS, St George-Hyslop PH.

Nat Rev Neurosci. 2002 Apr;3(4):281-90. Review. No abstract available.

PMID:
11967558
15.

JLK inhibitors: isocoumarin compounds as putative probes to selectively target the gamma-secretase pathway.

Checler F, Alves da Costa C, Ayral E, Andrau D, Dumanchin C, Farzan M, Hernandez JF, Martinez J, Lefranc-Jullien S, Marambaud P, Pasini A, Petit A, Phiel C, Robert P, St George-Hyslop P, Wilk S.

Curr Alzheimer Res. 2005 Jul;2(3):327-34. Review. Erratum in: Curr Alzheimer Res. 2005 Oct;2(4):493. Frédéric, Checler [corrected to Checler, Frédéric]; Cristine, Alves da Costa [corrected to Alves da Costa, Cristine]; Erwan, Ayral [corrected to Ayral, Erwan]; David, Andrau [corrected to Andrau, David]; Cécile, Dumanchin [corrected to Dumanchin, Cécile]; Michael, Farzan [corrected to Farzan, Michael]; Jean-Francois, Hernandez [corrected to Hernandez, Jean-Francois]; Solveig, Lefranc-Jullien [corrected to Lefranc-Jullien, Solveig]; Philippe, Marambaud [corrected to Marambaud, Philippe]; Andrea, Pasini [corrected to Pasini, Andrea]; Agnés, Petit [corrected to Petit, Agnés]; Christopher, Phiel [corrected to Phiel, Christopher]; Philippe, Robert [corrected to Robert, Philippe]; Peter, St George-Hyslop, corrected to St George-Hyslop, Peter]; Sherwin, Wilk [corrected to Wilk, Sherwin].

PMID:
15974898
16.

Recent advances in the development of gamma-secretase inhibitors.

Josien H.

Curr Opin Drug Discov Devel. 2002 Jul;5(4):513-25. Review.

PMID:
12197309
17.

Gamma-secretase-mediated proteolysis in cell-surface-receptor signalling.

Fortini ME.

Nat Rev Mol Cell Biol. 2002 Sep;3(9):673-84. Review.

PMID:
12209127
18.

An amyloid-notch hypothesis for Alzheimer's disease.

Ethell DW.

Neuroscientist. 2010 Dec;16(6):614-7. doi: 10.1177/1073858410366162. Epub 2010 Jun 30. Review.

PMID:
20592273
19.

Emerging roles of the γ-secretase-notch axis in inflammation.

Cheng YL, Choi Y, Sobey CG, Arumugam TV, Jo DG.

Pharmacol Ther. 2015 Mar;147:80-90. doi: 10.1016/j.pharmthera.2014.11.005. Epub 2014 Nov 8. Review.

PMID:
25448038
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