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Items: 1 to 20 of 31

1.

Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease.

Yang LB, Lindholm K, Yan R, Citron M, Xia W, Yang XL, Beach T, Sue L, Wong P, Price D, Li R, Shen Y.

Nat Med. 2003 Jan;9(1):3-4. No abstract available.

PMID:
12514700
2.

BACE1: the beta-secretase enzyme in Alzheimer's disease.

Vassar R.

J Mol Neurosci. 2004;23(1-2):105-14. Review.

PMID:
15126696
3.

The molecular link between beta- and gamma-secretase activity on the amyloid beta precursor protein.

Tabaton M, Tamagno E.

Cell Mol Life Sci. 2007 Sep;64(17):2211-8. Review.

PMID:
17604999
4.

Expression and activity of beta-site amyloid precursor protein cleaving enzyme in Alzheimer's disease.

Johnston JA, Liu WW, Todd SA, Coulson DT, Murphy S, Irvine GB, Passmore AP.

Biochem Soc Trans. 2005 Nov;33(Pt 5):1096-100. Review.

PMID:
16246054
5.

The proteins BACE1 and BACE2 and beta-secretase activity in normal and Alzheimer's disease brain.

Stockley JH, O'Neill C.

Biochem Soc Trans. 2007 Jun;35(Pt 3):574-6. Review.

PMID:
17511655
6.

The secretases of Alzheimer's disease.

Wolfe MS.

Curr Top Dev Biol. 2003;54:233-61. Review. No abstract available.

PMID:
12696752
7.
8.

Secretase targets for Alzheimer's disease: identification and therapeutic potential.

Wolfe MS.

J Med Chem. 2001 Jun 21;44(13):2039-60. Review. No abstract available.

PMID:
11405641
9.

Alzheimer's beta-secretase cleaves a glycosyltransferase as a physiological substrate.

Kitazume S, Saido TC, Hashimoto Y.

Glycoconj J. 2004;20(1):59-62. Review.

PMID:
14973371
10.

Aspartic proteases involved in Alzheimer's disease.

Schmidt B.

Chembiochem. 2003 May 9;4(5):366-78. Review.

PMID:
12740808
11.

Transcriptional and translational regulation of BACE1 expression--implications for Alzheimer's disease.

Rossner S, Sastre M, Bourne K, Lichtenthaler SF.

Prog Neurobiol. 2006 Jun;79(2):95-111. Epub 2006 Aug 14. Review.

PMID:
16904810
12.

Secretase inhibitors for Alzheimer's disease: challenges of a promiscuous protease.

Pollack SJ, Lewis H.

Curr Opin Investig Drugs. 2005 Jan;6(1):35-47. Review.

PMID:
15675602
13.

Uncovering gamma-secretase.

Steiner H.

Curr Alzheimer Res. 2004 Aug;1(3):175-81. Review.

PMID:
15975065
14.

Memapsin 2 (beta-secretase) inhibitor drug, between fantasy and reality.

Ghosh AK, Bilcer G, Hong L, Koelsch G, Tang J.

Curr Alzheimer Res. 2007 Sep;4(4):418-22. Review.

PMID:
17908045
15.

Relationship between presenilinase and gamma-secretase.

Xia W.

Drug News Perspect. 2003 Mar;16(2):69-74. Review.

PMID:
12792666
16.

Inhibitors and modulators of beta- and gamma-secretase.

Schmidt B, Baumann S, Braun HA, Larbig G.

Curr Top Med Chem. 2006;6(4):377-92. Review.

PMID:
16611149
17.

[Alzheimer's disease: focus on beta-amyloid and gamma-secretase].

Iwatsubo T.

Tanpakushitsu Kakusan Koso. 2004 May;49(7 Suppl):1086-90. Review. Japanese. No abstract available.

PMID:
15168534
18.

[Secretases as targets for the treatment of Alzheimer's disease].

Luo HM, Gu F.

Sheng Li Ke Xue Jin Zhan. 2003 Apr;34(2):189-92. Review. Chinese. No abstract available.

PMID:
12889164
19.

Searching for the most effective screening system to identify cell-active inhibitors of beta-secretase.

Middendorp O, L├╝thi U, Hausch F, Barberis A.

Biol Chem. 2004 Jun;385(6):481-5. Review.

PMID:
15255179
20.

Regulation of the lipidation of beta-secretase by statins.

Parsons RB, Farrant JK, Price GC, Subramaniam D, Austen BM.

Biochem Soc Trans. 2007 Jun;35(Pt 3):577-82. Review.

PMID:
17511656
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