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Results: 18

1.

Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy.

Ravikumar B, Duden R, Rubinsztein DC.

Hum Mol Genet. 2002 May 1;11(9):1107-17.

PMID:
11978769
[PubMed - indexed for MEDLINE]
Free Article
2.

Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies.

Sarkar S, Ravikumar B, Floto RA, Rubinsztein DC.

Cell Death Differ. 2009 Jan;16(1):46-56. doi: 10.1038/cdd.2008.110. Epub 2008 Jul 18. Review.

PMID:
18636076
[PubMed - indexed for MEDLINE]
Free Article
3.

Aggregate-prone proteins are cleared from the cytosol by autophagy: therapeutic implications.

Williams A, Jahreiss L, Sarkar S, Saiki S, Menzies FM, Ravikumar B, Rubinsztein DC.

Curr Top Dev Biol. 2006;76:89-101. Review.

PMID:
17118264
[PubMed - indexed for MEDLINE]
4.

Huntington's disease: degradation of mutant huntingtin by autophagy.

Sarkar S, Rubinsztein DC.

FEBS J. 2008 Sep;275(17):4263-70. doi: 10.1111/j.1742-4658.2008.06562.x. Epub 2008 Jul 15. Review.

PMID:
18637946
[PubMed - indexed for MEDLINE]
5.

Role of autophagy in the clearance of mutant huntingtin: a step towards therapy?

Ravikumar B, Rubinsztein DC.

Mol Aspects Med. 2006 Oct-Dec;27(5-6):520-7. Epub 2006 Sep 14. Review.

PMID:
16973207
[PubMed - indexed for MEDLINE]
6.

Polyglutamine pathogenesis.

Ross CA, Wood JD, Schilling G, Peters MF, Nucifora FC Jr, Cooper JK, Sharp AH, Margolis RL, Borchelt DR.

Philos Trans R Soc Lond B Biol Sci. 1999 Jun 29;354(1386):1005-11. Review.

PMID:
10434299
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

The roles of intracellular protein-degradation pathways in neurodegeneration.

Rubinsztein DC.

Nature. 2006 Oct 19;443(7113):780-6. Review.

PMID:
17051204
[PubMed - indexed for MEDLINE]
8.

Dyneins, autophagy, aggregation and neurodegeneration.

Rubinsztein DC, Ravikumar B, Acevedo-Arozena A, Imarisio S, O'Kane CJ, Brown SD.

Autophagy. 2005 Oct-Dec;1(3):177-8. Epub 2005 Oct 21. Review.

PMID:
16874055
[PubMed - indexed for MEDLINE]
Free Article
9.

Clearance of mutant proteins as a therapeutic target in neurodegenerative diseases.

Krainc D.

Arch Neurol. 2010 Apr;67(4):388-92. doi: 10.1001/archneurol.2010.40. Review.

PMID:
20385902
[PubMed - indexed for MEDLINE]
10.

Small molecule enhancers of autophagy for neurodegenerative diseases.

Sarkar S, Rubinsztein DC.

Mol Biosyst. 2008 Sep;4(9):895-901. doi: 10.1039/b804606a. Epub 2008 Jul 4. Review.

PMID:
18704227
[PubMed - indexed for MEDLINE]
11.

Inositol and IP3 levels regulate autophagy: biology and therapeutic speculations.

Sarkar S, Rubinsztein DC.

Autophagy. 2006 Apr-Jun;2(2):132-4. Epub 2006 Apr 6. Review.

PMID:
16874097
[PubMed - indexed for MEDLINE]
Free Article
12.

Intracellular degradation of misfolded proteins in polyglutamine neurodegenerative diseases.

Li X, Li H, Li XJ.

Brain Res Rev. 2008 Nov;59(1):245-52. doi: 10.1016/j.brainresrev.2008.08.003. Epub 2008 Aug 23. Review.

PMID:
18773920
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Protective roles for induction of autophagy in multiple proteinopathies.

Menzies FM, Ravikumar B, Rubinsztein DC.

Autophagy. 2006 Jul-Sep;2(3):224-5. Epub 2006 Jul 10. Review.

PMID:
16874096
[PubMed - indexed for MEDLINE]
Free Article
14.

Autophagy in neurodegeneration and development.

Winslow AR, Rubinsztein DC.

Biochim Biophys Acta. 2008 Dec;1782(12):723-9. doi: 10.1016/j.bbadis.2008.06.010. Epub 2008 Jul 1. Review.

PMID:
18644437
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

The role of autophagy in neurodegenerative disease.

Nixon RA.

Nat Med. 2013 Aug;19(8):983-97. doi: 10.1038/nm.3232. Epub 2013 Aug 6. Review.

PMID:
23921753
[PubMed - indexed for MEDLINE]
16.

Autophagy, a guardian against neurodegeneration.

GarcĂ­a-Arencibia M, Hochfeld WE, Toh PP, Rubinsztein DC.

Semin Cell Dev Biol. 2010 Sep;21(7):691-8. doi: 10.1016/j.semcdb.2010.02.008. Epub 2010 Feb 24. Review.

PMID:
20188203
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Chemical inducers of autophagy that enhance the clearance of mutant proteins in neurodegenerative diseases.

Renna M, Jimenez-Sanchez M, Sarkar S, Rubinsztein DC.

J Biol Chem. 2010 Apr 9;285(15):11061-7. doi: 10.1074/jbc.R109.072181. Epub 2010 Feb 10. Review.

PMID:
20147746
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

[Autophagy-lysosome pathway and Parkinson's disease].

Fan XN, Wang G, Chen SD.

Sheng Li Ke Xue Jin Zhan. 2010 Aug;41(4):272-4. Review. Chinese. No abstract available.

PMID:
21416943
[PubMed - indexed for MEDLINE]

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