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Results: 15

Cited In for PubMed (Select 9822712)


Is the amyloid hypothesis of Alzheimer's disease therapeutically relevant?

Teich AF, Arancio O.

Biochem J. 2012 Sep 1;446(2):165-77. doi: 10.1042/BJ20120653. Review.


HPRT deficiency coordinately dysregulates canonical Wnt and presenilin-1 signaling: a neuro-developmental regulatory role for a housekeeping gene?

Kang TH, Guibinga GH, Jinnah HA, Friedmann T.

PLoS One. 2011 Jan 28;6(1):e16572. doi: 10.1371/journal.pone.0016572. Erratum in: PLoS One. 2011;6(3). doi: 10.1371/annotation/893f09fd-ab24-4119-93f4-44a03a3342f9. Jinnah, H A [added].


Mild cholesterol depletion reduces amyloid-beta production by impairing APP trafficking to the cell surface.

Guardia-Laguarta C, Coma M, Pera M, Clarimón J, Sereno L, Agulló JM, Molina-Porcel L, Gallardo E, Deng A, Berezovska O, Hyman BT, Blesa R, Gómez-Isla T, Lleó A.

J Neurochem. 2009 Jul;110(1):220-30. doi: 10.1111/j.1471-4159.2009.06126.x. Epub 2009 Apr 27.


Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease.

Trinchese F, Fa' M, Liu S, Zhang H, Hidalgo A, Schmidt SD, Yamaguchi H, Yoshii N, Mathews PM, Nixon RA, Arancio O.

J Clin Invest. 2008 Aug;118(8):2796-807. doi: 10.1172/JCI34254.


Gleevec increases levels of the amyloid precursor protein intracellular domain and of the amyloid-beta degrading enzyme neprilysin.

Eisele YS, Baumann M, Klebl B, Nordhammer C, Jucker M, Kilger E.

Mol Biol Cell. 2007 Sep;18(9):3591-600. Epub 2007 Jul 11.


The role of presenilin and its interacting proteins in the biogenesis of Alzheimer's beta amyloid.

Verdile G, Gandy SE, Martins RN.

Neurochem Res. 2007 Apr-May;32(4-5):609-23. Epub 2006 Aug 31. Review.


Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation.

Edbauer D, Winkler E, Haass C, Steiner H.

Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8666-71. Epub 2002 Jun 4.


Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch.

Sastre M, Steiner H, Fuchs K, Capell A, Multhaup G, Condron MM, Teplow DB, Haass C.

EMBO Rep. 2001 Sep;2(9):835-41. Epub 2001 Aug 23.


Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha -secretase ADAM 10.

Kojro E, Gimpl G, Lammich S, Marz W, Fahrenholz F.

Proc Natl Acad Sci U S A. 2001 May 8;98(10):5815-20. Epub 2001 Apr 17.


Inhibition of the ubiquitin-proteasome system in Alzheimer's disease.

Lam YA, Pickart CM, Alban A, Landon M, Jamieson C, Ramage R, Mayer RJ, Layfield R.

Proc Natl Acad Sci U S A. 2000 Aug 29;97(18):9902-6.


Separation of presenilin function in amyloid beta-peptide generation and endoproteolysis of Notch.

Kulic L, Walter J, Multhaup G, Teplow DB, Baumeister R, Romig H, Capell A, Steiner H, Haass C.

Proc Natl Acad Sci U S A. 2000 May 23;97(11):5913-8.


Phosphorylation of presenilin-2 regulates its cleavage by caspases and retards progression of apoptosis.

Walter J, Schindzielorz A, Grünberg J, Haass C.

Proc Natl Acad Sci U S A. 1999 Feb 16;96(4):1391-6.

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