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β-arrestin-1 contributes to brown fat function and directly interacts with PPARα and PPARγ.

Wang C, Zeng X, Zhou Z, Zhao J, Pei G.

Sci Rep. 2016 Jun 15;6:26999. doi: 10.1038/srep26999.


GQ-16, a TZD-Derived Partial PPARγ Agonist, Induces the Expression of Thermogenesis-Related Genes in Brown Fat and Visceral White Fat and Decreases Visceral Adiposity in Obese and Hyperglycemic Mice.

Coelho MS, de Lima CL, Royer C, Silva JB, Oliveira FC, Christ CG, Pereira SA, Bao SN, Lima MC, Pitta MG, Pitta IR, Neves FA, Amato AA.

PLoS One. 2016 May 3;11(5):e0154310. doi: 10.1371/journal.pone.0154310. eCollection 2016.


Allosteric Pathways in the PPARγ-RXRα nuclear receptor complex.

Ricci CG, Silveira RL, Rivalta I, Batista VS, Skaf MS.

Sci Rep. 2016 Jan 29;6:19940. doi: 10.1038/srep19940.


Dietary component isorhamnetin is a PPARγ antagonist and ameliorates metabolic disorders induced by diet or leptin deficiency.

Zhang Y, Gu M, Cai W, Yu L, Feng L, Zhang L, Zang Q, Wang Y, Wang D, Chen H, Tong Q, Ji G, Huang C.

Sci Rep. 2016 Jan 18;6:19288. doi: 10.1038/srep19288.


Unlock the Thermogenic Potential of Adipose Tissue: Pharmacological Modulation and Implications for Treatment of Diabetes and Obesity.

Peng XR, Gennemark P, O'Mahony G, Bartesaghi S.

Front Endocrinol (Lausanne). 2015 Nov 19;6:174. doi: 10.3389/fendo.2015.00174. eCollection 2015. Review.


SR2067 Reveals a Unique Kinetic and Structural Signature for PPARγ Partial Agonism.

van Marrewijk LM, Polyak SW, Hijnen M, Kuruvilla D, Chang MR, Shin Y, Kamenecka TM, Griffin PR, Bruning JB.

ACS Chem Biol. 2016 Jan 15;11(1):273-83. doi: 10.1021/acschembio.5b00580. Epub 2015 Dec 3.


Mechanisms of peroxisome proliferator activated receptor γ regulation by non-steroidal anti-inflammatory drugs.

Puhl AC, Milton FA, Cvoro A, Sieglaff DH, Campos JC, Bernardes A, Filgueira CS, Lindemann JL, Deng T, Neves FA, Polikarpov I, Webb P.

Nucl Recept Signal. 2015 Oct 5;13:e004. doi: 10.1621/nrs.13004. eCollection 2015.


Review of the Structural and Dynamic Mechanisms of PPARγ Partial Agonism.

Kroker AJ, Bruning JB.

PPAR Res. 2015;2015:816856. doi: 10.1155/2015/816856. Epub 2015 Sep 8. Review.


Structural and Dynamical Insight into PPARγ Antagonism: In Silico Study of the Ligand-Receptor Interactions of Non-Covalent Antagonists.

Fratev F, Tsakovska I, Al Sharif M, Mihaylova E, Pajeva I.

Int J Mol Sci. 2015 Jul 8;16(7):15405-24. doi: 10.3390/ijms160715405.


Selective targeting of PPARγ by the natural product chelerythrine with a unique binding mode and improved antidiabetic potency.

Zheng W, Qiu L, Wang R, Feng X, Han Y, Zhu Y, Chen D, Liu Y, Jin L, Li Y.

Sci Rep. 2015 Jul 17;5:12222. doi: 10.1038/srep12222.


Role of Peroxisome Proliferator-Activated Receptor γ in Ocular Diseases.

Zhang S, Gu H, Hu N.

J Ophthalmol. 2015;2015:275435. doi: 10.1155/2015/275435. Epub 2015 Jun 4. Review.


Clinical Significance of Peroxisome Proliferator-Activated Receptor γ and TRAP220 in Patients with Operable Colorectal Cancer.

Kwon KA, Yun J, Oh SY, Seo BG, Lee S, Lee JH, Kim SH, Choi HJ, Roh MS, Kim HJ.

Cancer Res Treat. 2016 Jan;48(1):198-207. doi: 10.4143/crt.2015.024. Epub 2015 Jun 23.


Evolutionary Pattern and Regulation Analysis to Support Why Diversity Functions Existed within PPAR Gene Family Members.

Zhou T, Yan X, Wang G, Liu H, Gan X, Zhang T, Wang J, Li L.

Biomed Res Int. 2015;2015:613910. doi: 10.1155/2015/613910. Epub 2015 Apr 15.


Phosphorylation of PPARγ Affects the Collective Motions of the PPARγ-RXRα-DNA Complex.

Lemkul JA, Lewis SN, Bassaganya-Riera J, Bevan DR.

PLoS One. 2015 May 8;10(5):e0123984. doi: 10.1371/journal.pone.0123984. eCollection 2015.


Integrative and systemic approaches for evaluating PPARβ/δ (PPARD) function.

Giordano Attianese GM, Desvergne B.

Nucl Recept Signal. 2015 Apr 27;13:e001. doi: 10.1621/nrs.13001. eCollection 2015. Review.


Identification of a novel selective agonist of PPARγ with no promotion of adipogenesis and less inhibition of osteoblastogenesis.

Liu C, Feng T, Zhu N, Liu P, Han X, Chen M, Wang X, Li N, Li Y, Xu Y, Si S.

Sci Rep. 2015 Apr 1;5:9530. doi: 10.1038/srep09530. Erratum in: Sci Rep. 2015;5:12185.


High salt diet modulates vascular response in A2AAR (+/+) and A 2AAR (-/-) mice: role of sEH, PPARγ, and K ATP channels.

Pradhan I, Ledent C, Mustafa SJ, Morisseau C, Nayeem MA.

Mol Cell Biochem. 2015 Jun;404(1-2):87-96. doi: 10.1007/s11010-015-2368-4. Epub 2015 Mar 5.


Structure of a biologically active estrogen receptor-coactivator complex on DNA.

Yi P, Wang Z, Feng Q, Pintilie GD, Foulds CE, Lanz RB, Ludtke SJ, Schmid MF, Chiu W, O'Malley BW.

Mol Cell. 2015 Mar 19;57(6):1047-58. doi: 10.1016/j.molcel.2015.01.025. Epub 2015 Feb 26.


Mapping functional group free energy patterns at protein occluded sites: nuclear receptors and G-protein coupled receptors.

Lakkaraju SK, Yu W, Raman EP, Hershfeld AV, Fang L, Deshpande DA, MacKerell AD Jr.

J Chem Inf Model. 2015 Mar 23;55(3):700-8. doi: 10.1021/ci500729k. Epub 2015 Feb 25.

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