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The pathophysiology of thrombocytopenia in chronic liver disease.

Mitchell O, Feldman DM, Diakow M, Sigal SH.

Hepat Med. 2016 Apr 15;8:39-50. doi: 10.2147/HMER.S74612. eCollection 2016. Review.


Calreticulin-mutant proteins induce megakaryocytic signaling to transform hematopoietic cells and undergo accelerated degradation and Golgi-mediated secretion.

Han L, Schubert C, Köhler J, Schemionek M, Isfort S, Brümmendorf TH, Koschmieder S, Chatain N.

J Hematol Oncol. 2016 May 13;9(1):45. doi: 10.1186/s13045-016-0275-0.


Association between secondary thrombocytosis and viral respiratory tract infections in children.

Zheng SY, Xiao QY, Xie XH, Deng Y, Ren L, Tian DY, Luo ZX, Luo J, Fu Z, Huang AL, Liu EM.

Sci Rep. 2016 Mar 11;6:22964. doi: 10.1038/srep22964.


H2S protects against fatal myelosuppression by promoting the generation of megakaryocytes/platelets.

Liu HD, Zhang AJ, Xu JJ, Chen Y, Zhu YC.

J Hematol Oncol. 2016 Feb 24;9:13. doi: 10.1186/s13045-016-0244-7.


Thrombopoietin: a potential diagnostic indicator of immune thrombocytopenia in pregnancy.

Zhang X, Zhao Y, Li X, Han P, Jing F, Kong Z, Zhou H, Qiu J, Li L, Peng J, Hou M.

Oncotarget. 2016 Feb 16;7(7):7489-96. doi: 10.18632/oncotarget.7106.


Megakaryocyte- and megakaryocyte precursor-related gene therapies.

Wilcox DA.

Blood. 2016 Mar 10;127(10):1260-8. doi: 10.1182/blood-2015-07-607937. Epub 2016 Jan 19. Review.


Thrombopoietin induces production of nucleated thrombocytes from liver cells in Xenopus laevis.

Tanizaki Y, Ichisugi M, Obuchi-Shimoji M, Ishida-Iwata T, Tahara-Mogi A, Meguro-Ishikawa M, Kato T.

Sci Rep. 2015 Dec 21;5:18519. doi: 10.1038/srep18519.


Origins of the Vertebrate Erythro/Megakaryocytic System.

Svoboda O, Bartunek P.

Biomed Res Int. 2015;2015:632171. doi: 10.1155/2015/632171. Epub 2015 Oct 18. Review.


Management of Thrombocytopenia in Chronic Liver Disease: Focus on Pharmacotherapeutic Strategies.

Maan R, de Knegt RJ, Veldt BJ.

Drugs. 2015 Nov;75(17):1981-92. doi: 10.1007/s40265-015-0480-0.


Recombinant human thrombopoietin promotes hematopoietic reconstruction after severe whole body irradiation.

Wang C, Zhang B, Wang S, Zhang J, Liu Y, Wang J, Fan Z, Lv Y, Zhang X, He L, Chen L, Xia H, Li Y, Pei X.

Sci Rep. 2015 Sep 25;5:12993. doi: 10.1038/srep12993.


C-Mpl Is Expressed on Osteoblasts and Osteoclasts and Is Important in Regulating Skeletal Homeostasis.

Meijome TE, Baughman JT, Hooker RA, Cheng YH, Ciovacco WA, Balamohan SM, Srinivasan TL, Chitteti BR, Eleniste PP, Horowitz MC, Srour EF, Bruzzaniti A, Fuchs RK, Kacena MA.

J Cell Biochem. 2016 Apr;117(4):959-69. doi: 10.1002/jcb.25380. Epub 2015 Oct 6.


Inhibition of poly(ADP-ribose) polymerase 1 protects against acute myeloid leukemia by suppressing the myeloproliferative leukemia virus oncogene.

Wang L, Cai W, Zhang W, Chen X, Dong W, Tang D, Zhang Y, Ji C, Zhang M.

Oncotarget. 2015 Sep 29;6(29):27490-504. doi: 10.18632/oncotarget.4748.


Thrombocytopenia in Dengue: Interrelationship between Virus and the Imbalance between Coagulation and Fibrinolysis and Inflammatory Mediators.

de Azeredo EL, Monteiro RQ, de-Oliveira Pinto LM.

Mediators Inflamm. 2015;2015:313842. doi: 10.1155/2015/313842. Epub 2015 Apr 27. Review.


IL-1α induces thrombopoiesis through megakaryocyte rupture in response to acute platelet needs.

Nishimura S, Nagasaki M, Kunishima S, Sawaguchi A, Sakata A, Sakaguchi H, Ohmori T, Manabe I, Italiano JE Jr, Ryu T, Takayama N, Komuro I, Kadowaki T, Eto K, Nagai R.

J Cell Biol. 2015 May 11;209(3):453-66. doi: 10.1083/jcb.201410052.


Pak2 restrains endomitosis during megakaryopoiesis and alters cytoskeleton organization.

Kosoff RE, Aslan JE, Kostyak JC, Dulaimi E, Chow HY, Prudnikova TY, Radu M, Kunapuli SP, McCarty OJ, Chernoff J.

Blood. 2015 May 7;125(19):2995-3005. doi: 10.1182/blood-2014-10-604504. Epub 2015 Mar 30.


Efficient generation of megakaryocytes from human induced pluripotent stem cells using food and drug administration-approved pharmacological reagents.

Liu Y, Wang Y, Gao Y, Forbes JA, Qayyum R, Becker L, Cheng L, Wang ZZ.

Stem Cells Transl Med. 2015 Apr;4(4):309-19. doi: 10.5966/sctm.2014-0183. Epub 2015 Feb 23.


A novel role for thrombopoietin in regulating osteoclast development in humans and mice.

Bethel M, Barnes CL, Taylor AF, Cheng YH, Chitteti BR, Horowitz MC, Bruzzaniti A, Srour EF, Kacena MA.

J Cell Physiol. 2015 Sep;230(9):2142-51. doi: 10.1002/jcp.24943.


Romiplostim as a treatment for immune thrombocytopenia: a review.

Chalmers S, Tarantino MD.

J Blood Med. 2015 Jan 19;6:37-44. doi: 10.2147/JBM.S47240. eCollection 2015. Review.


A multicenter randomized open-label study of rituximab plus rhTPO vs rituximab in corticosteroid-resistant or relapsed ITP.

Zhou H, Xu M, Qin P, Zhang HY, Yuan CL, Zhao HG, Cui ZG, Meng YS, Wang L, Zhou F, Wang X, Li DQ, Bi KH, Zhu CS, Guo CS, Chu XX, Wu QC, Liu XG, Dong XY, Li J, Peng J, Hou M.

Blood. 2015 Mar 5;125(10):1541-7. doi: 10.1182/blood-2014-06-581868. Epub 2015 Jan 9.


The utility of thrombopoietin in predicting liver fibrosis in chronic hepatitis B.

Yilmaz B, Basar O, Altınbas A, Ekiz F, Aktas B, Oztürk G, Ginis Z, Coban S, Ucar E, Erarslan E, Coskun Y, Yüksel I, Tuna Y, Yüksel O.

Int J Clin Exp Med. 2014 May 15;7(5):1430-4. eCollection 2014.

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