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PAR3-aPKC regulates Tiam1 by modulating suppressive internal interactions.

Matsuzawa K, Akita H, Watanabe T, Kakeno M, Matsui T, Wang S, Kaibuchi K.

Mol Biol Cell. 2016 May 1;27(9):1511-23. doi: 10.1091/mbc.E15-09-0670. Epub 2016 Mar 3.


Biological effects of RNAi targeted inhibiting Tiam1 gene expression on cholangiocarcinoma cells.

Cheng W, Liu Y, Zuo Z, Yin X, Jiang B, Chen D, Peng C, Yang J.

Int J Clin Exp Pathol. 2015 Dec 1;8(12):15511-26. eCollection 2015.


The prognostic value of Tiam1 protein expression in head and neck squamous cell carcinoma: a retrospective study.

Yang H, Cai YC, Cao Y, Song M, An X, Xia Y, Wei J, Jiang WQ, Shi YX.

Chin J Cancer. 2015 Sep 14;34(12):614-21. doi: 10.1186/s40880-015-0053-3.


Constructing de novo H2O2 signaling via induced protein proximity.

Zeng G, Zhang R, Xuan W, Wang W, Liang FS.

ACS Chem Biol. 2015 Jun 19;10(6):1404-10. doi: 10.1021/acschembio.5b00170. Epub 2015 Mar 18.


MicroRNA-377 suppresses cell proliferation and invasion by inhibiting TIAM1 expression in hepatocellular carcinoma.

Chen G, Lu L, Liu C, Shan L, Yuan D.

PLoS One. 2015 Mar 4;10(3):e0117714. doi: 10.1371/journal.pone.0117714. eCollection 2015.


By downregulating TIAM1 expression, microRNA-329 suppresses gastric cancer invasion and growth.

Li Z, Yu X, Wang Y, Shen J, Wu WK, Liang J, Feng F.

Oncotarget. 2015 Jul 10;6(19):17559-69.


RhoC mediates epidermal growth factor-stimulated migration and invasion in head and neck squamous cell carcinoma.

Tumur Z, Katebzadeh S, Guerra C, Bhushan L, Alkam T, Henson BS.

Neoplasia. 2015 Jan;17(1):141-51. doi: 10.1016/j.neo.2014.12.002.


HUWE1 ubiquitylates and degrades the RAC activator TIAM1 promoting cell-cell adhesion disassembly, migration, and invasion.

Vaughan L, Tan CT, Chapman A, Nonaka D, Mack NA, Smith D, Booton R, Hurlstone AF, Malliri A.

Cell Rep. 2015 Jan 6;10(1):88-102. doi: 10.1016/j.celrep.2014.12.012. Epub 2014 Dec 24.


Light control of cellular processes by using photocaged abscisic acid.

Wright CW, Guo ZF, Liang FS.

Chembiochem. 2015 Jan 19;16(2):254-61. doi: 10.1002/cbic.201402576. Epub 2014 Dec 21.


Degradation of Tiam1 by casein kinase 1 and the SCFβTrCP ubiquitin ligase controls the duration of mTOR-S6K signaling.

Magliozzi R, Kim J, Low TY, Heck AJ, Guardavaccaro D.

J Biol Chem. 2014 Oct 3;289(40):27400-9. doi: 10.1074/jbc.M114.575571. Epub 2014 Aug 14.


Expression of Tiam1 predicts lymph node metastasis and poor survival of lung adenocarcinoma patients.

Liu S, Li Y, Qi W, Zhao Y, Huang A, Sheng W, Lei B, Lin P, Zhu H, Li W, Shen H.

Diagn Pathol. 2014 Mar 24;9:69. doi: 10.1186/1746-1596-9-69.


RhoGEFs in cell motility: novel links between Rgnef and focal adhesion kinase.

Miller NL, Kleinschmidt EG, Schlaepfer DD.

Curr Mol Med. 2014 Feb;14(2):221-34. Review.


The sirtuins promote Dishevelled-1 scaffolding of TIAM1, Rac activation and cell migration.

Saxena M, Dykes SS, Malyarchuk S, Wang AE, Cardelli JA, Pruitt K.

Oncogene. 2015 Jan 8;34(2):188-98. doi: 10.1038/onc.2013.549. Epub 2013 Dec 23.


A purine nucleotide biosynthesis enzyme guanosine monophosphate reductase is a suppressor of melanoma invasion.

Wawrzyniak JA, Bianchi-Smiraglia A, Bshara W, Mannava S, Ackroyd J, Bagati A, Omilian AR, Im M, Fedtsova N, Miecznikowski JC, Moparthy KC, Zucker SN, Zhu Q, Kozlova NI, Berman AE, Hoek KS, Gudkov AV, Shewach DS, Morrison CD, Nikiforov MA.

Cell Rep. 2013 Oct 31;5(2):493-507. doi: 10.1016/j.celrep.2013.09.015. Epub 2013 Oct 17.


Tubulin, actin and heterotrimeric G proteins: coordination of signaling and structure.

Schappi JM, Krbanjevic A, Rasenick MM.

Biochim Biophys Acta. 2014 Feb;1838(2):674-81. doi: 10.1016/j.bbamem.2013.08.026. Epub 2013 Sep 23. Review.


Tiam1 transgenic mice display increased tumor invasive and metastatic potential of colorectal cancer after 1,2-dimethylhydrazine treatment.

Yu LN, Zhang QL, Li X, Hua X, Cui YM, Zhang NJ, Liao WT, Ding YQ.

PLoS One. 2013 Sep 12;8(9):e73077. doi: 10.1371/journal.pone.0073077. eCollection 2013.


A Rac1/Cdc42 GTPase-specific small molecule inhibitor suppresses growth of primary human prostate cancer xenografts and prolongs survival in mice.

Zins K, Lucas T, Reichl P, Abraham D, Aharinejad S.

PLoS One. 2013 Sep 11;8(9):e74924. doi: 10.1371/journal.pone.0074924. eCollection 2013.


RNAi mediated Tiam1 gene knockdown inhibits invasion of retinoblastoma.

Subramanian N, Navaneethakrishnan S, Biswas J, Kanwar RK, Kanwar JR, Krishnakumar S.

PLoS One. 2013 Aug 7;8(8):e70422. doi: 10.1371/journal.pone.0070422. eCollection 2013.

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