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Sepsis-induced immune dysfunction: can immune therapies reduce mortality?

Delano MJ, Ward PA.

J Clin Invest. 2016 Jan;126(1):23-31. doi: 10.1172/JCI82224. Epub 2016 Jan 4. Review.


Insights into the Role of Chemokines, Damage-Associated Molecular Patterns, and Lymphocyte-Derived Mediators from Computational Models of Trauma-Induced Inflammation.

Namas RA, Mi Q, Namas R, Almahmoud K, Zaaqoq AM, Abdul-Malak O, Azhar N, Day J, Abboud A, Zamora R, Billiar TR, Vodovotz Y.

Antioxid Redox Signal. 2015 Dec 10;23(17):1370-87. doi: 10.1089/ars.2015.6398.


Intestine immune homeostasis after alcohol and burn injury.

Li X, Hammer AM, Rendon JL, Choudhry MA.

Shock. 2015 Jun;43(6):540-8. doi: 10.1097/SHK.0000000000000353. Review.


Concept of the aortic aneurysm repair-related surgical stress: a review of the literature.

Moris DN, Kontos MI, Mantonakis EI, Athanasiou AK, Spartalis ED, Bakoyiannis CN, Chrousos GP, Georgopoulos SE.

Int J Clin Exp Med. 2014 Sep 15;7(9):2402-12. eCollection 2014. Review.


N-terminal pro-C-natriuretic peptide and cytokine kinetics in dogs with endotoxemia.

Floras AN, Holowaychuk MK, Bienzle D, Bersenas AM, Sharif S, Harvey T, Nordone SK, Wood GA.

J Vet Intern Med. 2014 Sep-Oct;28(5):1447-53. doi: 10.1111/jvim.12409. Epub 2014 Jul 23.


Blockade of the T cell immunoglobulin and mucin domain protein 3 pathway exacerbates sepsis-induced immune deviation and immunosuppression.

Zhao Z, Jiang X, Kang C, Xiao Y, Hou C, Yu J, Wang R, Xiao H, Zhou T, Wen Z, Feng J, Chen G, Ma Y, Shen B, Li Y, Han G.

Clin Exp Immunol. 2014 Nov;178(2):279-91. doi: 10.1111/cei.12401.


Impact of sepsis on CD4 T cell immunity.

Cabrera-Perez J, Condotta SA, Badovinac VP, Griffith TS.

J Leukoc Biol. 2014 Nov;96(5):767-77. doi: 10.1189/jlb.5MR0114-067R. Epub 2014 May 2. Review.


Changes in serum cytokines in response to musculoskeletal surgical trauma.

Reikeras O, Borgen P, Reseland JE, Lyngstadaas SP.

BMC Res Notes. 2014 Mar 7;7:128. doi: 10.1186/1756-0500-7-128.


G-CSF drives a posttraumatic immune program that protects the host from infection.

Gardner JC, Noel JG, Nikolaidis NM, Karns R, Aronow BJ, Ogle CK, McCormack FX.

J Immunol. 2014 Mar 1;192(5):2405-17. doi: 10.4049/jimmunol.1302752. Epub 2014 Jan 27.


The effect of levamisole on mortality rate among patients with severe burn injuries.

Fatemi MJ, Salehi H, Akbari H, Alinejad F, Saberi M, Mousavi SJ, Soltani M, Taghavi S, Payandan H.

J Res Med Sci. 2013 Sep;18(9):795-800.


Protective Effects of Huang-Lian-Jie-Du-Tang against Polymicrobial Sepsis Induced by Cecal Ligation and Puncture in Rats.

Wei Y, Shan L, Qiao L, Liu R, Hu Z, Zhang W.

Evid Based Complement Alternat Med. 2013;2013:909624. doi: 10.1155/2013/909624. Epub 2013 Dec 4.


Burn wound γδ T-cells support a Th2 and Th17 immune response.

Rani M, Zhang Q, Schwacha MG.

J Burn Care Res. 2014 Jan-Feb;35(1):46-53. doi: 10.1097/


Interleukin-19 in breast cancer.

Chen YY, Li CF, Yeh CH, Chang MS, Hsing CH.

Clin Dev Immunol. 2013;2013:294320. doi: 10.1155/2013/294320. Epub 2013 Apr 22. Review.


Overactivation of mitogen-activated protein kinase and suppression of mitofusin-2 expression are two independent events in high mobility group box 1 protein-mediated T cell immune dysfunction.

Lu ZQ, Tang LM, Zhao GJ, Yao YM, Zhu XM, Dong N, Yu Y.

J Interferon Cytokine Res. 2013 Sep;33(9):529-41. doi: 10.1089/jir.2012.0054. Epub 2013 May 22.


Survival and cell mediated immunity after burn injury in aged mice.

Kovacs EJ, Grabowski KA, Duffner LA, Plackett TP, Gregory MS.

J Am Aging Assoc. 2002 Jan;25(1):3-9. doi: 10.1007/s11357-002-0001-4.


The molecular mechanism of hypertrophic scar.

Zhu Z, Ding J, Shankowsky HA, Tredget EE.

J Cell Commun Signal. 2013 Dec;7(4):239-52. doi: 10.1007/s12079-013-0195-5. Epub 2013 Mar 18.


Effects of azithromycin in Pseudomonas aeruginosa burn wound infection.

Nichols DP, Caceres S, Caverly L, Fratelli C, Kim SH, Malcolm K, Poch KR, Saavedra M, Solomon G, Taylor-Cousar J, Moskowitz S, Nick JA.

J Surg Res. 2013 Aug;183(2):767-76. doi: 10.1016/j.jss.2013.02.003. Epub 2013 Feb 24.


Immune system phenotyping of radiation and radiation combined injury in outbred mice.

Tajima G, Delisle AJ, Hoang K, O'Leary FM, Ikeda K, Hanschen M, Stoecklein VM, Lederer JA.

Radiat Res. 2013 Jan;179(1):101-12. doi: 10.1667/RR3120.1. Epub 2012 Dec 5.



Ayala A, Ding Y, Rhee RJ, Doughty LA, Grutkoski PS, Chung CS.

Rec Res Dev Immunol. 2003 Jan 12;5:13-35.


Inducible nitric oxide synthase contributes to immune dysfunction following trauma.

Darwiche SS, Pfeifer R, Menzel C, Ruan X, Hoffman M, Cai C, Chanthaphavong RS, Loughran P, Pitt BR, Hoffman R, Pape HC, Billiar TR.

Shock. 2012 Nov;38(5):499-507. doi: 10.1097/SHK.0b013e31826c5afe.

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