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Torin2 Suppresses Ionizing Radiation-Induced DNA Damage Repair.

Udayakumar D, Pandita RK, Horikoshi N, Liu Y, Liu Q, Wong KK, Hunt CR, Gray NS, Minna JD, Pandita TK, Westover KD.

Radiat Res. 2016 May;185(5):527-38. doi: 10.1667/RR14373.1. Epub 2016 May 2.


Inhibition of the Mechanistic Target of Rapamycin (mTOR)-Rapamycin and Beyond.

Lamming DW.

Cold Spring Harb Perspect Med. 2016 May 2;6(5). pii: a025924. doi: 10.1101/cshperspect.a025924. Review.


Novel links in the plant TOR kinase signaling network.

Xiong Y, Sheen J.

Curr Opin Plant Biol. 2015 Dec;28:83-91. doi: 10.1016/j.pbi.2015.09.006. Epub 2015 Oct 24. Review.


mTOR and differential activation of mitochondria orchestrate neutrophil chemotaxis.

Bao Y, Ledderose C, Graf AF, Brix B, Birsak T, Lee A, Zhang J, Junger WG.

J Cell Biol. 2015 Sep 28;210(7):1153-64. doi: 10.1083/jcb.201503066.


Autophagy knocked down by high-risk HPV infection and uterine cervical carcinogenesis.

Li X, Gong Z, Zhang L, Zhao C, Zhao X, Gu X, Chen H.

Int J Clin Exp Med. 2015 Jul 15;8(7):10304-14. eCollection 2015. Review.


Lysosomal calcium signalling regulates autophagy through calcineurin and ​TFEB.

Medina DL, Di Paola S, Peluso I, Armani A, De Stefani D, Venditti R, Montefusco S, Scotto-Rosato A, Prezioso C, Forrester A, Settembre C, Wang W, Gao Q, Xu H, Sandri M, Rizzuto R, De Matteis MA, Ballabio A.

Nat Cell Biol. 2015 Mar;17(3):288-99.


mTOR kinase: a possible pharmacological target in the management of chronic pain.

Lisi L, Aceto P, Navarra P, Dello Russo C.

Biomed Res Int. 2015;2015:394257. doi: 10.1155/2015/394257. Epub 2015 Jan 1. Review.


Master Regulators in Plant Glucose Signaling Networks.

Sheen J.

J. Plant Biol.. 2014 Apr;57(2):67-79.


Mirk/dyrk1B kinase is upregulated following inhibition of mTOR.

Deng X, Hu J, Ewton DZ, Friedman E.

Carcinogenesis. 2014 Sep;35(9):1968-76. doi: 10.1093/carcin/bgu058. Epub 2014 Mar 3.


Torin1-mediated TOR kinase inhibition reduces Wee1 levels and advances mitotic commitment in fission yeast and HeLa cells.

Atkin J, Halova L, Ferguson J, Hitchin JR, Lichawska-Cieslar A, Jordan AM, Pines J, Wellbrock C, Petersen J.

J Cell Sci. 2014 Mar 15;127(Pt 6):1346-56. doi: 10.1242/jcs.146373. Epub 2014 Jan 14.


The role of target of rapamycin signaling networks in plant growth and metabolism.

Xiong Y, Sheen J.

Plant Physiol. 2014 Feb;164(2):499-512. doi: 10.1104/pp.113.229948. Epub 2014 Jan 2. Review.


Rapamycin-insensitive mTORC1 activity controls eIF4E:4E-BP1 binding.

Livingstone M, Bidinosti M.

F1000Res. 2012 Jul 18;1:4. doi: 10.12688/f1000research.1-4.v1. eCollection 2012.


mTOR regulates phagosome and entotic vacuole fission.

Krajcovic M, Krishna S, Akkari L, Joyce JA, Overholtzer M.

Mol Biol Cell. 2013 Dec;24(23):3736-45. doi: 10.1091/mbc.E13-07-0408. Epub 2013 Oct 2.


mTOR kinase inhibitors as potential cancer therapeutic drugs.

Sun SY.

Cancer Lett. 2013 Oct 28;340(1):1-8. doi: 10.1016/j.canlet.2013.06.017. Epub 2013 Jun 20. Review.


Profiling protein kinases and other ATP binding proteins in Arabidopsis using Acyl-ATP probes.

Villamor JG, Kaschani F, Colby T, Oeljeklaus J, Zhao D, Kaiser M, Patricelli MP, van der Hoorn RA.

Mol Cell Proteomics. 2013 Sep;12(9):2481-96. doi: 10.1074/mcp.M112.026278. Epub 2013 May 29.


Glucose-TOR signalling reprograms the transcriptome and activates meristems.

Xiong Y, McCormack M, Li L, Hall Q, Xiang C, Sheen J.

Nature. 2013 Apr 11;496(7444):181-6. doi: 10.1038/nature12030. Epub 2013 Mar 31.


Developing irreversible inhibitors of the protein kinase cysteinome.

Liu Q, Sabnis Y, Zhao Z, Zhang T, Buhrlage SJ, Jones LH, Gray NS.

Chem Biol. 2013 Feb 21;20(2):146-59. doi: 10.1016/j.chembiol.2012.12.006. Review.


Different patterns of Akt and ERK feedback activation in response to rapamycin, active-site mTOR inhibitors and metformin in pancreatic cancer cells.

Soares HP, Ni Y, Kisfalvi K, Sinnett-Smith J, Rozengurt E.

PLoS One. 2013;8(2):e57289. doi: 10.1371/journal.pone.0057289. Epub 2013 Feb 21.


Characterization of Torin2, an ATP-competitive inhibitor of mTOR, ATM, and ATR.

Liu Q, Xu C, Kirubakaran S, Zhang X, Hur W, Liu Y, Kwiatkowski NP, Wang J, Westover KD, Gao P, Ercan D, Niepel M, Thoreen CC, Kang SA, Patricelli MP, Wang Y, Tupper T, Altabef A, Kawamura H, Held KD, Chou DM, Elledge SJ, Janne PA, Wong KK, Sabatini DM, Gray NS.

Cancer Res. 2013 Apr 15;73(8):2574-86. doi: 10.1158/0008-5472.CAN-12-1702. Epub 2013 Feb 22.

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