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Items: 1 to 20 of 61

1.

Drug Repurposing Is a New Opportunity for Developing Drugs against Neuropsychiatric Disorders.

Lee HM, Kim Y.

Schizophr Res Treatment. 2016;2016:6378137. doi: 10.1155/2016/6378137. Epub 2016 Mar 17. Review.

2.

The role of kinetic context in apparent biased agonism at GPCRs.

Klein Herenbrink C, Sykes DA, Donthamsetti P, Canals M, Coudrat T, Shonberg J, Scammells PJ, Capuano B, Sexton PM, Charlton SJ, Javitch JA, Christopoulos A, Lane JR.

Nat Commun. 2016 Feb 24;7:10842. doi: 10.1038/ncomms10842.

3.

Developmental Inhibition of Gsk3 Rescues Behavioral and Neurophysiological Deficits in a Mouse Model of Schizophrenia Predisposition.

Tamura M, Mukai J, Gordon JA, Gogos JA.

Neuron. 2016 Mar 2;89(5):1100-9. doi: 10.1016/j.neuron.2016.01.025. Epub 2016 Feb 18.

4.

DREADDs for Neuroscientists.

Roth BL.

Neuron. 2016 Feb 17;89(4):683-94. doi: 10.1016/j.neuron.2016.01.040. Review.

PMID:
26889809
6.

Receptor, Ligand and Transducer Contributions to Dopamine D2 Receptor Functional Selectivity.

Peterson SM, Pack TF, Caron MG.

PLoS One. 2015 Oct 30;10(10):e0141637. doi: 10.1371/journal.pone.0141637. eCollection 2015.

7.

Unique Effects of Acute Aripiprazole Treatment on the Dopamine D2 Receptor Downstream cAMP-PKA and Akt-GSK3β Signalling Pathways in Rats.

Pan B, Chen J, Lian J, Huang XF, Deng C.

PLoS One. 2015 Jul 10;10(7):e0132722. doi: 10.1371/journal.pone.0132722. eCollection 2015.

8.

Effects of β-Arrestin-Biased Dopamine D2 Receptor Ligands on Schizophrenia-Like Behavior in Hypoglutamatergic Mice.

Park SM, Chen M, Schmerberg CM, Dulman RS, Rodriguiz RM, Caron MG, Jin J, Wetsel WC.

Neuropsychopharmacology. 2016 Feb;41(3):704-15. doi: 10.1038/npp.2015.196. Epub 2015 Jul 1.

PMID:
26129680
9.

Single Amino Acid Variation Underlies Species-Specific Sensitivity to Amphibian Skin-Derived Opioid-like Peptides.

Vardy E, Sassano MF, Rennekamp AJ, Kroeze WK, Mosier PD, Westkaemper RB, Stevens CW, Katritch V, Stevens RC, Peterson RT, Roth BL.

Chem Biol. 2015 Jun 18;22(6):764-75. doi: 10.1016/j.chembiol.2015.05.012.

PMID:
26091169
10.

Monitoring β-arrestin recruitment via β-lactamase enzyme fragment complementation: purification of peptide E as a low-affinity ligand for mammalian bombesin receptors.

Ikeda Y, Kumagai H, Okazaki H, Fujishiro M, Motozawa Y, Nomura S, Takeda N, Toko H, Takimoto E, Akazawa H, Morita H, Suzuki J, Yamazaki T, Komuro I, Yanagisawa M.

PLoS One. 2015 Jun 1;10(6):e0127445. doi: 10.1371/journal.pone.0127445. eCollection 2015.

11.

Agonist signalling properties of radiotracers used for imaging of dopamine D2/3 receptors.

van Wieringen JP, Michel MC, Janssen HM, Janssen AG, Elsinga PH, Booij J.

EJNMMI Res. 2014 Oct 7;4:53. doi: 10.1186/s13550-014-0053-3. eCollection 2014.

12.

Targeting G protein coupled receptor-related pathways as emerging molecular therapies.

Ghanemi A.

Saudi Pharm J. 2015 Apr;23(2):115-29. doi: 10.1016/j.jsps.2013.07.007. Epub 2013 Aug 13. Review.

13.

PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome.

Kroeze WK, Sassano MF, Huang XP, Lansu K, McCorvy JD, Giguère PM, Sciaky N, Roth BL.

Nat Struct Mol Biol. 2015 May;22(5):362-9. doi: 10.1038/nsmb.3014. Epub 2015 Apr 20.

14.

Cariprazine exerts antimanic properties and interferes with dopamine D2 receptor β-arrestin interactions.

Gao Y, Peterson S, Masri B, Hougland MT, Adham N, Gyertyán I, Kiss B, Caron MG, El-Mallakh RS.

Pharmacol Res Perspect. 2015 Feb;3(1):e00073. doi: 10.1002/prp2.73. Epub 2014 Dec 2.

15.

Dopamine receptors - IUPHAR Review 13.

Beaulieu JM, Espinoza S, Gainetdinov RR.

Br J Pharmacol. 2015 Jan;172(1):1-23. Review.

16.

Structure and function of serotonin G protein-coupled receptors.

McCorvy JD, Roth BL.

Pharmacol Ther. 2015 Jun;150:129-42. doi: 10.1016/j.pharmthera.2015.01.009. Epub 2015 Jan 17. Review.

PMID:
25601315
18.

Bias analyses of preclinical and clinical D2 dopamine ligands: studies with immediate and complex signaling pathways.

Brust TF, Hayes MP, Roman DL, Burris KD, Watts VJ.

J Pharmacol Exp Ther. 2015 Mar;352(3):480-93. doi: 10.1124/jpet.114.220293. Epub 2014 Dec 24.

19.

New functional activity of aripiprazole revealed: Robust antagonism of D2 dopamine receptor-stimulated Gβγ signaling.

Brust TF, Hayes MP, Roman DL, Watts VJ.

Biochem Pharmacol. 2015 Jan 1;93(1):85-91. doi: 10.1016/j.bcp.2014.10.014. Epub 2014 Nov 7.

20.

Mice lacking the circadian modulators SHARP1 and SHARP2 display altered sleep and mixed state endophenotypes of psychiatric disorders.

Baier PC, Brzózka MM, Shahmoradi A, Reinecke L, Kroos C, Wichert SP, Oster H, Wehr MC, Taneja R, Hirrlinger J, Rossner MJ.

PLoS One. 2014 Oct 23;9(10):e110310. doi: 10.1371/journal.pone.0110310. eCollection 2014.

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