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The application of tetracyclineregulated gene expression systems in the validation of novel drug targets in Mycobacterium tuberculosis.

Evans JC, Mizrahi V.

Front Microbiol. 2015 Aug 4;6:812. doi: 10.3389/fmicb.2015.00812. eCollection 2015. Review.


The Oxidative Stress Network of Mycobacterium tuberculosis Reveals Coordination between Radical Detoxification Systems.

Nambi S, Long JE, Mishra BB, Baker R, Murphy KC, Olive AJ, Nguyen HP, Shaffer SA, Sassetti CM.

Cell Host Microbe. 2015 Jun 10;17(6):829-37. doi: 10.1016/j.chom.2015.05.008.


Qualitative and quantitative proteomic analysis of Vitamin C induced changes in Mycobacterium smegmatis.

Mishra A, Sarkar D.

Front Microbiol. 2015 May 18;6:451. doi: 10.3389/fmicb.2015.00451. eCollection 2015.


Essential Genes in the Core Genome of the Human Pathogen Streptococcus pyogenes.

Le Breton Y, Belew AT, Valdes KM, Islam E, Curry P, Tettelin H, Shirtliff ME, El-Sayed NM, McIver KS.

Sci Rep. 2015 May 21;5:9838. doi: 10.1038/srep09838.


A comprehensive map of genome-wide gene regulation in Mycobacterium tuberculosis.

Turkarslan S, Peterson EJ, Rustad TR, Minch KJ, Reiss DJ, Morrison R, Ma S, Price ND, Sherman DR, Baliga NS.

Sci Data. 2015 Mar 31;2:150010. doi: 10.1038/sdata.2015.10. eCollection 2015.


RNase HI Is Essential for Survival of Mycobacterium smegmatis.

Minias AE, Brzostek AM, Korycka-Machala M, Dziadek B, Minias P, Rajagopalan M, Madiraju M, Dziadek J.

PLoS One. 2015 May 12;10(5):e0126260. doi: 10.1371/journal.pone.0126260. eCollection 2015.


Characterization of genome-wide ordered sequence-tagged Mycobacterium mutant libraries by Cartesian Pooling-Coordinate Sequencing.

Vandewalle K, Festjens N, Plets E, Vuylsteke M, Saeys Y, Callewaert N.

Nat Commun. 2015 May 11;6:7106. doi: 10.1038/ncomms8106.


Target mechanism-based whole-cell screening identifies bortezomib as an inhibitor of caseinolytic protease in mycobacteria.

Moreira W, Ngan GJ, Low JL, Poulsen A, Chia BC, Ang MJ, Yap A, Fulwood J, Lakshmanan U, Lim J, Khoo AY, Flotow H, Hill J, Raju RM, Rubin EJ, Dick T.

MBio. 2015 May 5;6(3):e00253-15. doi: 10.1128/mBio.00253-15.


Role of intragenic binding of cAMP responsive protein (CRP) in regulation of the succinate dehydrogenase genes Rv0249c-Rv0247c in TB complex mycobacteria.

Knapp GS, Lyubetskaya A, Peterson MW, Gomes AL, Ma Z, Galagan JE, McDonough KA.

Nucleic Acids Res. 2015 Jun 23;43(11):5377-93. doi: 10.1093/nar/gkv420. Epub 2015 May 4.


Essential Role of the ESX-5 Secretion System in Outer Membrane Permeability of Pathogenic Mycobacteria.

Ates LS, Ummels R, Commandeur S, van der Weerd R, Sparrius M, Weerdenburg E, Alber M, Kalscheuer R, Piersma SR, Abdallah AM, Abd El Ghany M, Abdel-Haleem AM, Pain A, Jiménez CR, Bitter W, Houben EN.

PLoS Genet. 2015 May 4;11(5):e1005190. doi: 10.1371/journal.pgen.1005190. eCollection 2015 May.


The Mycobacterium tuberculosis ClpP1P2 Protease Interacts Asymmetrically with Its ATPase Partners ClpX and ClpC1.

Leodolter J, Warweg J, Weber-Ban E.

PLoS One. 2015 May 1;10(5):e0125345. doi: 10.1371/journal.pone.0125345. eCollection 2015.


Isolation and Characterization of a Hybrid Respiratory Supercomplex Consisting of Mycobacterium tuberculosis Cytochrome bcc and Mycobacterium smegmatis Cytochrome aa3.

Kim MS, Jang J, Ab Rahman NB, Pethe K, Berry EA, Huang LS.

J Biol Chem. 2015 Jun 5;290(23):14350-60. doi: 10.1074/jbc.M114.624312. Epub 2015 Apr 10.


Comparative whole-genome analysis of clinical isolates reveals characteristic architecture of Mycobacterium tuberculosis pangenome.

Periwal V, Patowary A, Vellarikkal SK, Gupta A, Singh M, Mittal A, Jeyapaul S, Chauhan RK, Singh AV, Singh PK, Garg P, Katoch VM, Katoch K, Chauhan DS, Sivasubbu S, Scaria V.

PLoS One. 2015 Apr 8;10(4):e0122979. doi: 10.1371/journal.pone.0122979. eCollection 2015.


An adenosine triphosphate-independent proteasome activator contributes to the virulence of Mycobacterium tuberculosis.

Jastrab JB, Wang T, Murphy JP, Bai L, Hu K, Merkx R, Huang J, Chatterjee C, Ovaa H, Gygi SP, Li H, Darwin KH.

Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):E1763-72. doi: 10.1073/pnas.1423319112. Epub 2015 Mar 23.


Auranofin exerts broad-spectrum bactericidal activities by targeting thiol-redox homeostasis.

Harbut MB, Vilchèze C, Luo X, Hensler ME, Guo H, Yang B, Chatterjee AK, Nizet V, Jacobs WR Jr, Schultz PG, Wang F.

Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):4453-8. doi: 10.1073/pnas.1504022112. Epub 2015 Mar 23.


Structural basis for competitive inhibition of 3,4-dihydroxy-2-butanone-4-phosphate synthase from Vibrio cholerae.

Islam Z, Kumar A, Singh S, Salmon L, Karthikeyan S.

J Biol Chem. 2015 May 1;290(18):11293-308. doi: 10.1074/jbc.M114.611830. Epub 2015 Mar 18.


Phosphoproteomics analysis of a clinical Mycobacterium tuberculosis Beijing isolate: expanding the mycobacterial phosphoproteome catalog.

Fortuin S, Tomazella GG, Nagaraj N, Sampson SL, Gey van Pittius NC, Soares NC, Wiker HG, de Souza GA, Warren RM.

Front Microbiol. 2015 Feb 10;6:6. doi: 10.3389/fmicb.2015.00006. eCollection 2015.


Mycobacterial genes essential for the pathogen's survival in the host.

Ehrt S, Rhee K, Schnappinger D.

Immunol Rev. 2015 Mar;264(1):319-26. doi: 10.1111/imr.12256.


Genome-wide transposon mutagenesis indicates that Mycobacterium marinum customizes its virulence mechanisms for survival and replication in different hosts.

Weerdenburg EM, Abdallah AM, Rangkuti F, Abd El Ghany M, Otto TD, Adroub SA, Molenaar D, Ummels R, Ter Veen K, van Stempvoort G, van der Sar AM, Ali S, Langridge GC, Thomson NR, Pain A, Bitter W.

Infect Immun. 2015 May;83(5):1778-88. doi: 10.1128/IAI.03050-14. Epub 2015 Feb 17.


A novel antimycobacterial compound acts as an intracellular iron chelator.

Dragset MS, Poce G, Alfonso S, Padilla-Benavides T, Ioerger TR, Kaneko T, Sacchettini JC, Biava M, Parish T, Argüello JM, Steigedal M, Rubin EJ.

Antimicrob Agents Chemother. 2015 Apr;59(4):2256-64. doi: 10.1128/AAC.05114-14. Epub 2015 Feb 2.

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