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RanGTP aids anaphase entry through Ubr5-mediated protein turnover.

Jiang H, He X, Feng D, Zhu X, Zheng Y.

J Cell Biol. 2015 Oct 12;211(1):7-18. doi: 10.1083/jcb.201503122. Epub 2015 Oct 5.


Human Herpesvirus-6 U14 Induces Cell-Cycle Arrest in G2/M Phase by Associating with a Cellular Protein, EDD.

Mori J, Kawabata A, Tang H, Tadagaki K, Mizuguchi H, Kuroda K, Mori Y.

PLoS One. 2015 Sep 4;10(9):e0137420. doi: 10.1371/journal.pone.0137420. eCollection 2015.


The MLLE domain of the ubiquitin ligase UBR5 binds to its catalytic domain to regulate substrate binding.

Muñoz-Escobar J, Matta-Camacho E, Kozlov G, Gehring K.

J Biol Chem. 2015 Sep 11;290(37):22841-50. doi: 10.1074/jbc.M115.672246. Epub 2015 Jul 29.


EDD, a ubiquitin-protein ligase of the N-end rule pathway, associates with spindle assembly checkpoint components and regulates the mitotic response to nocodazole.

Scialpi F, Mellis D, Ditzel M.

J Biol Chem. 2015 May 15;290(20):12585-94. doi: 10.1074/jbc.M114.625673. Epub 2015 Apr 1.


Regulation of DNA damage responses and cell cycle progression by hMOB2.

Gomez V, Gundogdu R, Gomez M, Hoa L, Panchal N, O'Driscoll M, Hergovich A.

Cell Signal. 2015 Feb;27(2):326-39. doi: 10.1016/j.cellsig.2014.11.016. Epub 2014 Nov 21.


UBR5-mediated ubiquitination of ATMIN is required for ionizing radiation-induced ATM signaling and function.

Zhang T, Cronshaw J, Kanu N, Snijders AP, Behrens A.

Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):12091-6. doi: 10.1073/pnas.1400230111. Epub 2014 Aug 4.


Phosphorylation-dependent PIH1D1 interactions define substrate specificity of the R2TP cochaperone complex.

Hořejší Z, Stach L, Flower TG, Joshi D, Flynn H, Skehel JM, O'Reilly NJ, Ogrodowicz RW, Smerdon SJ, Boulton SJ.

Cell Rep. 2014 Apr 10;7(1):19-26. doi: 10.1016/j.celrep.2014.03.013. Epub 2014 Mar 20.


The novel interaction between microspherule protein Msp58 and ubiquitin E3 ligase EDD regulates cell cycle progression.

Benavides M, Chow-Tsang LF, Zhang J, Zhong H.

Biochim Biophys Acta. 2013 Jan;1833(1):21-32. doi: 10.1016/j.bbamcr.2012.10.007. Epub 2012 Oct 12.


A novel role for RIP1 kinase in mediating TNFα production.

Christofferson DE, Li Y, Hitomi J, Zhou W, Upperman C, Zhu H, Gerber SA, Gygi S, Yuan J.

Cell Death Dis. 2012 Jun 14;3:e320. doi: 10.1038/cddis.2012.64.


Serum starvation induced cell cycle synchronization facilitates human somatic cells reprogramming.

Chen M, Huang J, Yang X, Liu B, Zhang W, Huang L, Deng F, Ma J, Bai Y, Lu R, Huang B, Gao Q, Zhuo Y, Ge J.

PLoS One. 2012;7(4):e28203. doi: 10.1371/journal.pone.0028203. Epub 2012 Apr 18.


The N-end rule pathway.

Tasaki T, Sriram SM, Park KS, Kwon YT.

Annu Rev Biochem. 2012;81:261-89. doi: 10.1146/annurev-biochem-051710-093308. Epub 2012 Apr 10. Review.


Effects of EDD on p53 function are context-specific.

Watts CK, Saunders DN.

J Biol Chem. 2011 Jul 15;286(28):le13; author reply le14. doi: 10.1074/jbc.L110.182527. No abstract available.

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