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A novel ER-microtubule-binding protein, ERLIN2, stabilizes Cyclin B1 and regulates cell cycle progression.

Zhang X, Cai J, Zheng Z, Polin L, Lin Z, Dandekar A, Li L, Sun F, Finley RL Jr, Fang D, Yang ZQ, Zhang K.

Cell Discov. 2015 Sep 8;1:15024. doi: 10.1038/celldisc.2015.24. eCollection 2015.


Contribution of Accelerated Degradation to Feedback Regulation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase and Cholesterol Metabolism in the Liver.

Hwang S, Hartman IZ, Calhoun LN, Garland K, Young GA, Mitsche MA, McDonald J, Xu F, Engelking L, DeBose-Boyd RA.

J Biol Chem. 2016 Jun 24;291(26):13479-94. doi: 10.1074/jbc.M116.728469. Epub 2016 Apr 29.


gp78 functions downstream of Hrd1 to promote degradation of misfolded proteins of the endoplasmic reticulum.

Zhang T, Xu Y, Liu Y, Ye Y.

Mol Biol Cell. 2015 Dec 1;26(24):4438-50. doi: 10.1091/mbc.E15-06-0354. Epub 2015 Sep 30.


The prenyltransferase UBIAD1 is the target of geranylgeraniol in degradation of HMG CoA reductase.

Schumacher MM, Elsabrouty R, Seemann J, Jo Y, DeBose-Boyd RA.

Elife. 2015 Mar 5;4. doi: 10.7554/eLife.05560.


Human liver cytochrome P450 3A4 ubiquitination: molecular recognition by UBC7-gp78 autocrine motility factor receptor and UbcH5a-CHIP-Hsc70-Hsp40 E2-E3 ubiquitin ligase complexes.

Wang Y, Kim SM, Trnka MJ, Liu Y, Burlingame AL, Correia MA.

J Biol Chem. 2015 Feb 6;290(6):3308-32. doi: 10.1074/jbc.M114.611525. Epub 2014 Dec 1.


USP13 antagonizes gp78 to maintain functionality of a chaperone in ER-associated degradation.

Liu Y, Soetandyo N, Lee JG, Liu L, Xu Y, Clemons WM Jr, Ye Y.

Elife. 2014;3:e01369. doi: 10.7554/eLife.01369. Epub 2014 Jan 14.


Different functions of HOPS isoforms in the cell: HOPS shuttling isoform is determined by RIP cleavage system.

Castelli M, Piobbico D, Bartoli D, Pieroni S, Brunacci C, Bellet MM, Chiacchiaretta M, Della Fazia MA, Servillo G.

Cell Cycle. 2014;13(2):293-302. doi: 10.4161/cc.27054. Epub 2013 Feb 1.


Erlins restrict SREBP activation in the ER and regulate cellular cholesterol homeostasis.

Huber MD, Vesely PW, Datta K, Gerace L.

J Cell Biol. 2013 Nov 11;203(3):427-36. doi: 10.1083/jcb.201305076.


Interaction between salt-inducible kinase 2 (SIK2) and p97/valosin-containing protein (VCP) regulates endoplasmic reticulum (ER)-associated protein degradation in mammalian cells.

Yang FC, Lin YH, Chen WH, Huang JY, Chang HY, Su SH, Wang HT, Chiang CY, Hsu PH, Tsai MD, Tan BC, Lee SC.

J Biol Chem. 2013 Nov 22;288(47):33861-72. doi: 10.1074/jbc.M113.492199. Epub 2013 Oct 15.


Sterol homeostasis requires regulated degradation of squalene monooxygenase by the ubiquitin ligase Doa10/Teb4.

Foresti O, Ruggiano A, Hannibal-Bach HK, Ejsing CS, Carvalho P.

Elife. 2013 Jul 23;2:e00953. doi: 10.7554/eLife.00953.


Sterol metabolism regulates neuroserpin polymer degradation in the absence of the unfolded protein response in the dementia FENIB.

Roussel BD, Newton TM, Malzer E, Simecek N, Haq I, Thomas SE, Burr ML, Lehner PJ, Crowther DC, Marciniak SJ, Lomas DA.

Hum Mol Genet. 2013 Nov 15;22(22):4616-26. doi: 10.1093/hmg/ddt310. Epub 2013 Jun 28.


Lipid-regulated degradation of HMG-CoA reductase and Insig-1 through distinct mechanisms in insect cells.

Faulkner RA, Nguyen AD, Jo Y, DeBose-Boyd RA.

J Lipid Res. 2013 Apr;54(4):1011-22. doi: 10.1194/jlr.M033639. Epub 2013 Feb 12.


SGTA recognizes a noncanonical ubiquitin-like domain in the Bag6-Ubl4A-Trc35 complex to promote endoplasmic reticulum-associated degradation.

Xu Y, Cai M, Yang Y, Huang L, Ye Y.

Cell Rep. 2012 Dec 27;2(6):1633-44. doi: 10.1016/j.celrep.2012.11.010. Epub 2012 Dec 13.


The mammalian endoplasmic reticulum-associated degradation system.

Olzmann JA, Kopito RR, Christianson JC.

Cold Spring Harb Perspect Biol. 2013 Sep 1;5(9). pii: a013185. doi: 10.1101/cshperspect.a013185. Review.


Live cell imaging of protein dislocation from the endoplasmic reticulum.

Zhong Y, Fang S.

J Biol Chem. 2012 Aug 10;287(33):28057-66. doi: 10.1074/jbc.M112.381798. Epub 2012 Jun 21.


Endoplasmic reticulum factor ERLIN2 regulates cytosolic lipid content in cancer cells.

Wang G, Zhang X, Lee JS, Wang X, Yang ZQ, Zhang K.

Biochem J. 2012 Sep 15;446(3):415-25. doi: 10.1042/BJ20112050.


ERLIN2 promotes breast cancer cell survival by modulating endoplasmic reticulum stress pathways.

Wang G, Liu G, Wang X, Sethi S, Ali-Fehmi R, Abrams J, Zheng Z, Zhang K, Ethier S, Yang ZQ.

BMC Cancer. 2012 Jun 8;12:225. doi: 10.1186/1471-2407-12-225.


The delicate balance between secreted protein folding and endoplasmic reticulum-associated degradation in human physiology.

Guerriero CJ, Brodsky JL.

Physiol Rev. 2012 Apr;92(2):537-76. doi: 10.1152/physrev.00027.2011. Review.


Sterol-induced degradation of HMG CoA reductase depends on interplay of two Insigs and two ubiquitin ligases, gp78 and Trc8.

Jo Y, Lee PC, Sguigna PV, DeBose-Boyd RA.

Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20503-8. doi: 10.1073/pnas.1112831108. Epub 2011 Dec 5.

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