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Lkb1 controls brown adipose tissue growth and thermogenesis by regulating the intracellular localization of CRTC3.

Shan T, Xiong Y, Zhang P, Li Z, Jiang Q, Bi P, Yue F, Yang G, Wang Y, Liu X, Kuang S.

Nat Commun. 2016 Jul 27;7:12205. doi: 10.1038/ncomms12205.


Hydrogen sulfide mediates the protection of dietary restriction against renal senescence in aged F344 rats.

Wang WJ, Cai GY, Ning YC, Cui J, Hong Q, Bai XY, Xu XM, Bu R, Sun XF, Chen XM.

Sci Rep. 2016 Jul 26;6:30292. doi: 10.1038/srep30292.


Dopamine signaling promotes the xenobiotic stress response and protein homeostasis.

Joshi KK, Matlack TL, Rongo C.

EMBO J. 2016 Sep 1;35(17):1885-901. doi: 10.15252/embj.201592524. Epub 2016 Jun 3.


The Aging Epigenome.

Booth LN, Brunet A.

Mol Cell. 2016 Jun 2;62(5):728-44. doi: 10.1016/j.molcel.2016.05.013. Review.


Synthetic Ligands of Cannabinoid Receptors Affect Dauer Formation in the Nematode Caenorhabditis elegans.

Reis Rodrigues P, Kaul TK, Ho JH, Lucanic M, Burkewitz K, Mair WB, Held JM, Bohn LM, Gill MS.

G3 (Bethesda). 2016 Jun 1;6(6):1695-705. doi: 10.1534/g3.116.026997.


Suppression of Kaposi's Sarcoma-Associated Herpesvirus Infection and Replication by 5'-AMP-Activated Protein Kinase.

Cheng F, He M, Jung JU, Lu C, Gao SJ.

J Virol. 2016 Jun 24;90(14):6515-25. doi: 10.1128/JVI.00624-16. Print 2016 Jul 15.


Finding Ponce de Leon's Pill: Challenges in Screening for Anti-Aging Molecules.

Kumar S, Lombard DB.

F1000Res. 2016 Mar 29;5. pii: F1000 Faculty Rev-406. doi: 10.12688/f1000research.7821.1. eCollection 2016. Review.


Cerium oxide nanoparticles promote neurogenesis and abrogate hypoxia-induced memory impairment through AMPK-PKC-CBP signaling cascade.

Arya A, Gangwar A, Singh SK, Roy M, Das M, Sethy NK, Bhargava K.

Int J Nanomedicine. 2016 Mar 23;11:1159-73. doi: 10.2147/IJN.S102096. eCollection 2016.


Characterization of the direct targets of FOXO transcription factors throughout evolution.

Webb AE, Kundaje A, Brunet A.

Aging Cell. 2016 Aug;15(4):673-85. doi: 10.1111/acel.12479. Epub 2016 Apr 8.


C. elegans S6K Mutants Require a Creatine-Kinase-like Effector for Lifespan Extension.

McQuary PR, Liao CY, Chang JT, Kumsta C, She X, Davis A, Chu CC, Gelino S, Gomez-Amaro RL, Petrascheck M, Brill LM, Ladiges WC, Kennedy BK, Hansen M.

Cell Rep. 2016 Mar 8;14(9):2059-67. doi: 10.1016/j.celrep.2016.02.012. Epub 2016 Feb 25.


AMP-Activated Protein Kinase Regulates Oxidative Metabolism in Caenorhabditis elegans through the NHR-49 and MDT-15 Transcriptional Regulators.

Moreno-Arriola E, El Hafidi M, Ortega-Cuéllar D, Carvajal K.

PLoS One. 2016 Jan 29;11(1):e0148089. doi: 10.1371/journal.pone.0148089. eCollection 2016.


When Anti-Aging Studies Meet Cancer Chemoprevention: Can Anti-Aging Agent Kill Two Birds with One Blow?

Yokoyama NN, Denmon A, Uchio EM, Jordan M, Mercola D, Zi X.

Curr Pharmacol Rep. 2015 Dec 1;1(6):420-433. Epub 2015 Apr 14.


Evolving Lessons on the Complex Role of AMPK in Normal Physiology and Cancer.

Dasgupta B, Chhipa RR.

Trends Pharmacol Sci. 2016 Mar;37(3):192-206. doi: 10.1016/ Epub 2015 Dec 20. Review.


AMPK activation protects from neuronal dysfunction and vulnerability across nematode, cellular and mouse models of Huntington's disease.

Vázquez-Manrique RP, Farina F, Cambon K, Dolores Sequedo M, Parker AJ, Millán JM, Weiss A, Déglon N, Neri C.

Hum Mol Genet. 2016 Mar 15;25(6):1043-58. doi: 10.1093/hmg/ddv513. Epub 2015 Dec 17.


Reciprocal Changes in Phosphoenolpyruvate Carboxykinase and Pyruvate Kinase with Age Are a Determinant of Aging in Caenorhabditis elegans.

Yuan Y, Hakimi P, Kao C, Kao A, Liu R, Janocha A, Boyd-Tressler A, Hang X, Alhoraibi H, Slater E, Xia K, Cao P, Shue Q, Ching TT, Hsu AL, Erzurum SC, Dubyak GR, Berger NA, Hanson RW, Feng Z.

J Biol Chem. 2016 Jan 15;291(3):1307-19. doi: 10.1074/jbc.M115.691766. Epub 2015 Dec 2.


Peripheral Circadian Clocks Mediate Dietary Restriction-Dependent Changes in Lifespan and Fat Metabolism in Drosophila.

Katewa SD, Akagi K, Bose N, Rakshit K, Camarella T, Zheng X, Hall D, Davis S, Nelson CS, Brem RB, Ramanathan A, Sehgal A, Giebultowicz JM, Kapahi P.

Cell Metab. 2016 Jan 12;23(1):143-54. doi: 10.1016/j.cmet.2015.10.014. Epub 2015 Nov 25.


Perspective of Small-Molecule AdipoR Agonist for Type 2 Diabetes and Short Life in Obesity.

Okada-Iwabu M, Iwabu M, Ueki K, Yamauchi T, Kadowaki T.

Diabetes Metab J. 2015 Oct;39(5):363-72. doi: 10.4093/dmj.2015.39.5.363. Epub 2015 Oct 22. Review.


Attenuation of AMPK signaling by ROQUIN promotes T follicular helper cell formation.

Ramiscal RR, Parish IA, Lee-Young RS, Babon JJ, Blagih J, Pratama A, Martin J, Hawley N, Cappello JY, Nieto PF, Ellyard JI, Kershaw NJ, Sweet RA, Goodnow CC, Jones RG, Febbraio MA, Vinuesa CG, Athanasopoulos V.

Elife. 2015 Oct 23;4. pii: e08698. doi: 10.7554/eLife.08698.


Repurposing metformin: an old drug with new tricks in its binding pockets.

Pryor R, Cabreiro F.

Biochem J. 2015 Nov 1;471(3):307-22. doi: 10.1042/BJ20150497. Review.


Identification of AMPK Phosphorylation Sites Reveals a Network of Proteins Involved in Cell Invasion and Facilitates Large-Scale Substrate Prediction.

Schaffer BE, Levin RS, Hertz NT, Maures TJ, Schoof ML, Hollstein PE, Benayoun BA, Banko MR, Shaw RJ, Shokat KM, Brunet A.

Cell Metab. 2015 Nov 3;22(5):907-21. doi: 10.1016/j.cmet.2015.09.009. Epub 2015 Oct 8.

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