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Bacillus anthracis Spore Surface Protein BclA Mediates Complement Factor H Binding to Spores and Promotes Spore Persistence.

Wang Y, Jenkins SA, Gu C, Shree A, Martinez-Moczygemba M, Herold J, Botto M, Wetsel RA, Xu Y.

PLoS Pathog. 2016 Jun 15;12(6):e1005678. doi: 10.1371/journal.ppat.1005678. eCollection 2016 Jun.


Meningococcal Factor H Binding Protein Vaccine Antigens with Increased Thermal Stability and Decreased Binding of Human Factor H.

Rossi R, Konar M, Beernink PT.

Infect Immun. 2016 May 24;84(6):1735-42. doi: 10.1128/IAI.01491-15. Print 2016 Jun.


Impact of Reducing Complement Inhibitor Binding on the Immunogenicity of Native Neisseria meningitidis Outer Membrane Vesicles.

Daniels-Treffandier H, de Nie K, Marsay L, Dold C, Sadarangani M, Reyes-Sandoval A, Langford PR, Wyllie D, Hill F, Pollard AJ, Rollier CS.

PLoS One. 2016 Feb 12;11(2):e0148840. doi: 10.1371/journal.pone.0148840. eCollection 2016.


A meningococcal NOMV-FHbp vaccine for Africa elicits broader serum bactericidal antibody responses against serogroup B and non-B strains than a licensed serogroup B vaccine.

Pajon R, Lujan E, Granoff DM.

Vaccine. 2016 Jan 27;34(5):643-9. doi: 10.1016/j.vaccine.2015.12.034. Epub 2015 Dec 20.


A meningococcal vaccine antigen engineered to increase thermal stability and stabilize protective epitopes.

Konar M, Pajon R, Beernink PT.

Proc Natl Acad Sci U S A. 2015 Dec 1;112(48):14823-8. doi: 10.1073/pnas.1507829112. Epub 2015 Nov 16.


Impaired Immunogenicity of Meningococcal Neisserial Surface Protein A in Human Complement Factor H Transgenic Mice.

Lujan E, Pajon R, Granoff DM.

Infect Immun. 2015 Nov 23;84(2):452-8. doi: 10.1128/IAI.01267-15.


Effect of complement Factor H on anti-FHbp serum bactericidal antibody responses of infant rhesus macaques boosted with a licensed meningococcal serogroup B vaccine.

Giuntini S, Beernink PT, Granoff DM.

Vaccine. 2015 Dec 16;33(51):7168-75. doi: 10.1016/j.vaccine.2015.10.135. Epub 2015 Nov 10.


Susceptibility of Meningococcal Strains Responsible for Two Serogroup B Outbreaks on U.S. University Campuses to Serum Bactericidal Activity Elicited by the MenB-4C Vaccine.

Rossi R, Beernink PT, Giuntini S, Granoff DM.

Clin Vaccine Immunol. 2015 Dec;22(12):1227-34. doi: 10.1128/CVI.00474-15. Epub 2015 Sep 30.


Beyond the Crystal Structure: Insight into the Function and Vaccine Potential of TbpA Expressed by Neisseria gonorrhoeae.

Cash DR, Noinaj N, Buchanan SK, Cornelissen CN.

Infect Immun. 2015 Nov;83(11):4438-49. doi: 10.1128/IAI.00762-15. Epub 2015 Sep 8.


A Newly-Identified Polymorphism in Rhesus Macaque Complement Factor H Modulates Binding Affinity for Meningococcal FHbp.

Konar M, Beernink PT, Granoff DM.

PLoS One. 2015 Aug 18;10(8):e0135996. doi: 10.1371/journal.pone.0135996. eCollection 2015.


Virulence of Group A Streptococci Is Enhanced by Human Complement Inhibitors.

Ermert D, Shaughnessy J, Joeris T, Kaplan J, Pang CJ, Kurt-Jones EA, Rice PA, Ram S, Blom AM.

PLoS Pathog. 2015 Jul 22;11(7):e1005043. doi: 10.1371/journal.ppat.1005043. eCollection 2015 Jul.


Functional Analysis of the Human Antibody Response to Meningococcal Factor H Binding Protein.

Beernink PT, Giuntini S, Costa I, Lucas AH, Granoff DM.

MBio. 2015 Jun 23;6(3):e00842. doi: 10.1128/mBio.00842-15.


Protein Crystallography in Vaccine Research and Development.

Malito E, Carfi A, Bottomley MJ.

Int J Mol Sci. 2015 Jun 9;16(6):13106-40. doi: 10.3390/ijms160613106. Review.


A Mutant Library Approach to Identify Improved Meningococcal Factor H Binding Protein Vaccine Antigens.

Konar M, Rossi R, Walter H, Pajon R, Beernink PT.

PLoS One. 2015 Jun 9;10(6):e0128185. doi: 10.1371/journal.pone.0128185. eCollection 2015.


Molecular basis of host specificity in human pathogenic bacteria.

Pan X, Yang Y, Zhang JR.

Emerg Microbes Infect. 2014 Mar;3(3):e23. doi: 10.1038/emi.2014.23. Epub 2014 Mar 26. Review.


Modulation of nasopharyngeal innate defenses by viral coinfection predisposes individuals to experimental pneumococcal carriage.

Glennie S, Gritzfeld JF, Pennington SH, Garner-Jones M, Coombes N, Hopkins MJ, Vadesilho CF, Miyaji EN, Wang D, Wright AD, Collins AM, Gordon SB, Ferreira DM.

Mucosal Immunol. 2016 Jan;9(1):56-67. doi: 10.1038/mi.2015.35. Epub 2015 Apr 29.


Binding of Complement Factor H (FH) Decreases Protective Anti-FH Binding Protein Antibody Responses of Infant Rhesus Macaques Immunized With a Meningococcal Serogroup B Vaccine.

Granoff DM, Costa I, Konar M, Giuntini S, Van Rompay KK, Beernink PT.

J Infect Dis. 2015 Sep 1;212(5):784-92. doi: 10.1093/infdis/jiv081. Epub 2015 Feb 12.


A native outer membrane vesicle vaccine confers protection against meningococcal colonization in human CEACAM1 transgenic mice.

Pajon R, Buckwalter CM, Johswich KO, Gray-Owen SD, Granoff DM.

Vaccine. 2015 Mar 10;33(11):1317-23. doi: 10.1016/j.vaccine.2015.01.057. Epub 2015 Feb 4.


Binding of complement factor H to PorB3 and NspA enhances resistance of Neisseria meningitidis to anti-factor H binding protein bactericidal activity.

Giuntini S, Pajon R, Ram S, Granoff DM.

Infect Immun. 2015 Apr;83(4):1536-45. doi: 10.1128/IAI.02984-14. Epub 2015 Feb 2.

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