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Results: 16

1.

Combined MEK and JAK inhibition abrogates murine myeloproliferative neoplasm.

Kong G, Wunderlich M, Yang D, Ranheim EA, Young KH, Wang J, Chang YI, Du J, Liu Y, Tey SR, Zhang X, Juckett M, Mattison R, Damnernsawad A, Zhang J, Mulloy JC, Zhang J.

J Clin Invest. 2014 Jun 2;124(6):2762-73. doi: 10.1172/JCI74182. Epub 2014 May 8.

PMID:
24812670
[PubMed - in process]
Free PMC Article
2.

Juvenile myelomonocytic leukemia: molecular pathogenesis informs current approaches to therapy and hematopoietic cell transplantation.

Dvorak CC, Loh ML.

Front Pediatr. 2014 Mar 28;2:25. doi: 10.3389/fped.2014.00025. eCollection 2014. Review.

PMID:
24734223
[PubMed]
Free PMC Article
3.

Cancer-associated IDH2 mutants drive an acute myeloid leukemia that is susceptible to Brd4 inhibition.

Chen C, Liu Y, Lu C, Cross JR, Morris JP 4th, Shroff AS, Ward PS, Bradner JE, Thompson C, Lowe SW.

Genes Dev. 2013 Sep 15;27(18):1974-85. doi: 10.1101/gad.226613.113.

PMID:
24065765
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Nras(G12D/+) promotes leukemogenesis by aberrantly regulating hematopoietic stem cell functions.

Wang J, Kong G, Liu Y, Du J, Chang YI, Tey SR, Zhang X, Ranheim EA, Saba-El-Leil MK, Meloche S, Damnernsawad A, Zhang J, Zhang J.

Blood. 2013 Jun 27;121(26):5203-7. doi: 10.1182/blood-2012-12-475863. Epub 2013 May 17.

PMID:
23687087
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Activated N-Ras signaling regulates arterial-venous specification in zebrafish.

Ren CG, Wang L, Jia XE, Liu YJ, Dong ZW, Jin Y, Chen Y, Deng M, Zhou Y, Zhou Y, Ren RB, Pan WJ, Liu TX.

J Hematol Oncol. 2013 May 12;6:34. doi: 10.1186/1756-8722-6-34.

PMID:
23663822
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

EVI1 inhibits apoptosis induced by antileukemic drugs via upregulation of CDKN1A/p21/WAF in human myeloid cells.

Rommer A, Steinmetz B, Herbst F, Hackl H, Heffeter P, Heilos D, Filipits M, Steinleitner K, Hemmati S, Herbacek I, Schwarzinger I, Hartl K, Rondou P, Glimm H, Karakaya K, Krämer A, Berger W, Wieser R.

PLoS One. 2013;8(2):e56308. doi: 10.1371/journal.pone.0056308. Epub 2013 Feb 14.

PMID:
23457546
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Direct reprogramming by oncogenic Ras and Myc.

Ischenko I, Zhi J, Moll UM, Nemajerova A, Petrenko O.

Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):3937-42. doi: 10.1073/pnas.1219592110. Epub 2013 Feb 19.

PMID:
23431158
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Mutant N-RAS protects colorectal cancer cells from stress-induced apoptosis and contributes to cancer development and progression.

Wang Y, Velho S, Vakiani E, Peng S, Bass AJ, Chu GC, Gierut J, Bugni JM, Der CJ, Philips M, Solit DB, Haigis KM.

Cancer Discov. 2013 Mar;3(3):294-307. doi: 10.1158/2159-8290.CD-12-0198. Epub 2012 Dec 28.

PMID:
23274911
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Rare codons regulate KRas oncogenesis.

Lampson BL, Pershing NL, Prinz JA, Lacsina JR, Marzluff WF, Nicchitta CV, MacAlpine DM, Counter CM.

Curr Biol. 2013 Jan 7;23(1):70-5. doi: 10.1016/j.cub.2012.11.031. Epub 2012 Dec 13.

PMID:
23246410
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Identification of mutant K-Ras-dependent phenotypes using a panel of isogenic cell lines.

Vartanian S, Bentley C, Brauer MJ, Li L, Shirasawa S, Sasazuki T, Kim JS, Haverty P, Stawiski E, Modrusan Z, Waldman T, Stokoe D.

J Biol Chem. 2013 Jan 25;288(4):2403-13. doi: 10.1074/jbc.M112.394130. Epub 2012 Nov 27.

PMID:
23188824
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Engineering mouse models with myelodysplastic syndrome human candidate genes; how relevant are they?

Beurlet S, Chomienne C, Padua RA.

Haematologica. 2013 Jan;98(1):10-22. doi: 10.3324/haematol.2012.069385. Epub 2012 Oct 12. Review.

PMID:
23065517
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Targeting oncogenic Ras signaling in hematologic malignancies.

Ward AF, Braun BS, Shannon KM.

Blood. 2012 Oct 25;120(17):3397-406. doi: 10.1182/blood-2012-05-378596. Epub 2012 Aug 16. Review.

PMID:
22898602
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Nras overexpression results in granulocytosis, T-cell expansion and early lethality in mice.

Lassen LB, Ballarín-González B, Schmitz A, Füchtbauer A, Pedersen FS, Füchtbauer EM.

PLoS One. 2012;7(8):e42216. doi: 10.1371/journal.pone.0042216. Epub 2012 Aug 2.

PMID:
22876308
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

PRAK suppresses oncogenic ras-induced hematopoietic cancer development by antagonizing the JNK pathway.

Yoshizuka N, Lai M, Liao R, Cook R, Xiao C, Han J, Sun P.

Mol Cancer Res. 2012 Jun;10(6):810-20. doi: 10.1158/1541-7786.MCR-11-0576. Epub 2012 Jun 4.

PMID:
22665523
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Inhibiting the palmitoylation/depalmitoylation cycle selectively reduces the growth of hematopoietic cells expressing oncogenic Nras.

Xu J, Hedberg C, Dekker FJ, Li Q, Haigis KM, Hwang E, Waldmann H, Shannon K.

Blood. 2012 Jan 26;119(4):1032-5. doi: 10.1182/blood-2011-06-358960. Epub 2011 Dec 5.

PMID:
22144181
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

RAS oncogenes: weaving a tumorigenic web.

Pylayeva-Gupta Y, Grabocka E, Bar-Sagi D.

Nat Rev Cancer. 2011 Oct 13;11(11):761-74. doi: 10.1038/nrc3106. Review.

PMID:
21993244
[PubMed - indexed for MEDLINE]
Free PMC Article

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