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Results: 1 to 20 of 76

1.

Nuclear TAR DNA-binding protein 43: A new target for amyotrophic lateral sclerosis treatment.

Zheng M, Shi Y, Fan D.

Neural Regen Res. 2013 Dec 15;8(35):3284-95. doi: 10.3969/j.issn.1673-5374.2013.35.003.

PMID:
25206650
[PubMed]
Free PMC Article
2.

HIV-1 Replication in Human Immune Cells Is Independent of TAR DNA Binding Protein 43 (TDP-43) Expression.

Nehls J, Koppensteiner H, Brack-Werner R, Floss T, Schindler M.

PLoS One. 2014 Aug 15;9(8):e105478. doi: 10.1371/journal.pone.0105478. eCollection 2014.

PMID:
25127017
[PubMed - in process]
Free PMC Article
3.

Prevention of intestinal obstruction reveals progressive neurodegeneration in mutant TDP-43 (A315T) mice.

Herdewyn S, Cirillo C, Van Den Bosch L, Robberecht W, Vanden Berghe P, Van Damme P.

Mol Neurodegener. 2014 Jun 17;9:24. doi: 10.1186/1750-1326-9-24.

PMID:
24938805
[PubMed - in process]
Free PMC Article
4.

Gene targeting of mouse Tardbp negatively affects Masp2 expression.

Dib S, Xiao S, Miletic D, Robertson J.

PLoS One. 2014 Apr 16;9(4):e95373. doi: 10.1371/journal.pone.0095373. eCollection 2014.

PMID:
24740308
[PubMed - in process]
Free PMC Article
5.

Allele-specific knockdown of ALS-associated mutant TDP-43 in neural stem cells derived from induced pluripotent stem cells.

Nishimura AL, Shum C, Scotter EL, Abdelgany A, Sardone V, Wright J, Lee YB, Chen HJ, Bilican B, Carrasco M, Maniatis T, Chandran S, Rogelj B, Gallo JM, Shaw CE.

PLoS One. 2014 Mar 20;9(3):e91269. doi: 10.1371/journal.pone.0091269. eCollection 2014.

PMID:
24651281
[PubMed - in process]
Free PMC Article
6.

Disease causing mutants of TDP-43 nucleic acid binding domains are resistant to aggregation and have increased stability and half-life.

Austin JA, Wright GS, Watanabe S, Grossmann JG, Antonyuk SV, Yamanaka K, Hasnain SS.

Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4309-14. doi: 10.1073/pnas.1317317111. Epub 2014 Mar 3.

PMID:
24591609
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

A nonsense mutation in mouse Tardbp affects TDP43 alternative splicing activity and causes limb-clasping and body tone defects.

Ricketts T, McGoldrick P, Fratta P, de Oliveira HM, Kent R, Phatak V, Brandner S, Blanco G, Greensmith L, Acevedo-Arozena A, Fisher EM.

PLoS One. 2014 Jan 21;9(1):e85962. doi: 10.1371/journal.pone.0085962. eCollection 2014.

PMID:
24465814
[PubMed - in process]
Free PMC Article
8.

The crystal structure of TDP-43 RRM1-DNA complex reveals the specific recognition for UG- and TG-rich nucleic acids.

Kuo PH, Chiang CH, Wang YT, Doudeva LG, Yuan HS.

Nucleic Acids Res. 2014 Apr;42(7):4712-22. doi: 10.1093/nar/gkt1407. Epub 2014 Jan 23.

PMID:
24464995
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Differential roles of the ubiquitin proteasome system and autophagy in the clearance of soluble and aggregated TDP-43 species.

Scotter EL, Vance C, Nishimura AL, Lee YB, Chen HJ, Urwin H, Sardone V, Mitchell JC, Rogelj B, Rubinsztein DC, Shaw CE.

J Cell Sci. 2014 Mar 15;127(Pt 6):1263-78. doi: 10.1242/jcs.140087. Epub 2014 Jan 14.

PMID:
24424030
[PubMed - in process]
Free PMC Article
10.

Predominance of spliceosomal complex formation over polyadenylation site selection in TDP-43 autoregulation.

Bembich S, Herzog JS, De Conti L, Stuani C, Avendaño-Vázquez SE, Buratti E, Baralle M, Baralle FE.

Nucleic Acids Res. 2014 Mar;42(5):3362-71. doi: 10.1093/nar/gkt1343. Epub 2013 Dec 24.

PMID:
24369426
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Transcription factor abundance controlled by an auto-regulatory mechanism involving a transcription start site switch.

Ngondo RP, Carbon P.

Nucleic Acids Res. 2014 Feb;42(4):2171-84. doi: 10.1093/nar/gkt1136. Epub 2013 Nov 14.

PMID:
24234445
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

ALS-associated FUS mutations result in compromised FUS alternative splicing and autoregulation.

Zhou Y, Liu S, Liu G, Oztürk A, Hicks GG.

PLoS Genet. 2013 Oct;9(10):e1003895. doi: 10.1371/journal.pgen.1003895. Epub 2013 Oct 31.

PMID:
24204307
[PubMed - in process]
Free PMC Article
13.

Downregulation of microRNA-9 in iPSC-derived neurons of FTD/ALS patients with TDP-43 mutations.

Zhang Z, Almeida S, Lu Y, Nishimura AL, Peng L, Sun D, Wu B, Karydas AM, Tartaglia MC, Fong JC, Miller BL, Farese RV Jr, Moore MJ, Shaw CE, Gao FB.

PLoS One. 2013 Oct 15;8(10):e76055. doi: 10.1371/journal.pone.0076055. eCollection 2013.

PMID:
24143176
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Principles of self-organization in biological pathways: a hypothesis on the autogenous association of alpha-synuclein.

Zanzoni A, Marchese D, Agostini F, Bolognesi B, Cirillo D, Botta-Orfila M, Livi CM, Rodriguez-Mulero S, Tartaglia GG.

Nucleic Acids Res. 2013 Dec;41(22):9987-98. doi: 10.1093/nar/gkt794. Epub 2013 Sep 3.

PMID:
24003031
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

TDP-43, an ALS linked protein, regulates fat deposition and glucose homeostasis.

Stallings NR, Puttaparthi K, Dowling KJ, Luther CM, Burns DK, Davis K, Elliott JL.

PLoS One. 2013 Aug 13;8(8):e71793. doi: 10.1371/journal.pone.0071793. eCollection 2013.

PMID:
23967244
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

The pathological phenotypes of human TDP-43 transgenic mouse models are independent of downregulation of mouse Tdp-43.

Xu YF, Prudencio M, Hubbard JM, Tong J, Whitelaw EC, Jansen-West K, Stetler C, Cao X, Song J, Zhang YJ.

PLoS One. 2013 Jul 26;8(7):e69864. doi: 10.1371/journal.pone.0069864. Print 2013.

PMID:
23922830
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Pathological mechanisms underlying TDP-43 driven neurodegeneration in FTLD-ALS spectrum disorders.

Janssens J, Van Broeckhoven C.

Hum Mol Genet. 2013 Oct 15;22(R1):R77-87. doi: 10.1093/hmg/ddt349. Epub 2013 Jul 29. Review.

PMID:
23900071
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Deep brain stimulation modulates nonsense-mediated RNA decay in Parkinson's patients leukocytes.

Soreq L, Bergman H, Israel Z, Soreq H.

BMC Genomics. 2013 Jul 16;14:478. doi: 10.1186/1471-2164-14-478.

PMID:
23865419
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Identification of LIN28B-bound mRNAs reveals features of target recognition and regulation.

Graf R, Munschauer M, Mastrobuoni G, Mayr F, Heinemann U, Kempa S, Rajewsky N, Landthaler M.

RNA Biol. 2013 Jul;10(7):1146-59. doi: 10.4161/rna.25194. Epub 2013 May 29.

PMID:
23770886
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Drosophila TDP-43 dysfunction in glia and muscle cells cause cytological and behavioural phenotypes that characterize ALS and FTLD.

Diaper DC, Adachi Y, Lazarou L, Greenstein M, Simoes FA, Di Domenico A, Solomon DA, Lowe S, Alsubaie R, Cheng D, Buckley S, Humphrey DM, Shaw CE, Hirth F.

Hum Mol Genet. 2013 Oct 1;22(19):3883-93. doi: 10.1093/hmg/ddt243. Epub 2013 May 31.

PMID:
23727833
[PubMed - indexed for MEDLINE]
Free PMC Article

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