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Valproic Acid Prevents Renal Dysfunction and Inflammation in the Ischemia-Reperfusion Injury Model.

Costalonga EC, Silva FM, Noronha IL.

Biomed Res Int. 2016;2016:5985903. doi: 10.1155/2016/5985903. Epub 2016 Apr 18.


Reversal of pentylenetetrazole-altered swimming and neural activity-regulated gene expression in zebrafish larvae by valproic acid and valerian extract.

Torres-Hernández BA, Colón LR, Rosa-Falero C, Torrado A, Miscalichi N, Ortíz JG, González-Sepúlveda L, Pérez-Ríos N, Suárez-Pérez E, Bradsher JN, Behra M.

Psychopharmacology (Berl). 2016 Jul;233(13):2533-47. doi: 10.1007/s00213-016-4304-z. Epub 2016 May 11.


Multi-Organ toxicity demonstration in a functional human in vitro system composed of four organs.

Oleaga C, Bernabini C, Smith AS, Srinivasan B, Jackson M, McLamb W, Platt V, Bridges R, Cai Y, Santhanam N, Berry B, Najjar S, Akanda N, Guo X, Martin C, Ekman G, Esch MB, Langer J, Ouedraogo G, Cotovio J, Breton L, Shuler ML, Hickman JJ.

Sci Rep. 2016 Feb 3;6:20030. doi: 10.1038/srep20030.


Valproic acid potentiates the anticancer activity of capecitabine in vitro and in vivo in breast cancer models via induction of thymidine phosphorylase expression.

Terranova-Barberio M, Roca MS, Zotti AI, Leone A, Bruzzese F, Vitagliano C, Scogliamiglio G, Russo D, D'Angelo G, Franco R, Budillon A, Di Gennaro E.

Oncotarget. 2016 Feb 16;7(7):7715-31. doi: 10.18632/oncotarget.6802.


Valproic acid inhibits the invasion of PC3 prostate cancer cells by upregulating the metastasis suppressor protein NDRG1.

Lee JE, Kim JH.

Genet Mol Biol. 2015 Dec;38(4):527-33. doi: 10.1590/S1415-475738420150028.


Effect of piperine on pharmacokinetics of sodium valproate in plasma samples of rats using gas chromatography-mass spectrometry method.

Parveen B, Pillai KK, Tamboli ET, Ahmad S.

J Pharm Bioallied Sci. 2015 Oct-Dec;7(4):317-20. doi: 10.4103/0975-7406.168036.


Histone acetylation: novel target for the treatment of acute lymphoblastic leukemia.

Zhang C, Zhong JF, Stucky A, Chen XL, Press MF, Zhang X.

Clin Epigenetics. 2015 Nov 4;7:117. doi: 10.1186/s13148-015-0151-8. eCollection 2015. Review.


Application of a patient-derived xenograft model in cytolytic viral activation therapy for nasopharyngeal carcinoma.

Hsu CL, Kuo YC, Huang Y, Huang YC, Lui KW, Chang KP, Lin TL, Fan HC, Lin AC, Hsieh CH, Lee LY, Wang HM, Li HP, Chang YS.

Oncotarget. 2015 Oct 13;6(31):31323-34. doi: 10.18632/oncotarget.5544.


Valproic acid enhances the efficacy of radiation therapy by protecting normal hippocampal neurons and sensitizing malignant glioblastoma cells.

Thotala D, Karvas RM, Engelbach JA, Garbow JR, Hallahan AN, DeWees TA, Laszlo A, Hallahan DE.

Oncotarget. 2015 Oct 27;6(33):35004-22. doi: 10.18632/oncotarget.5253.


Changes in the Peripheral Blood Gene Expression Profile Induced by 3 Months of Valproate Treatment in Patients with Newly Diagnosed Epilepsy.

Rakitin A, Kõks S, Reimann E, Prans E, Haldre S.

Front Neurol. 2015 Aug 31;6:188. doi: 10.3389/fneur.2015.00188. eCollection 2015.


Pharmacologically relevant doses of valproate upregulate CD20 expression in three diffuse large B-cell lymphoma patients in vivo.

Damm JK, Gordon S, Ehinger M, Jerkeman M, Gullberg U, Hultquist A, Drott K.

Exp Hematol Oncol. 2015 Jan 26;4:4. doi: 10.1186/2162-3619-4-4. eCollection 2015.


GSK3β-activation is a point of convergence for HIV-1 and opiate-mediated interactive neurotoxicity.

Masvekar RR, El-Hage N, Hauser KF, Knapp PE.

Mol Cell Neurosci. 2015 Mar;65:11-20. doi: 10.1016/j.mcn.2015.01.001. Epub 2015 Jan 20.


Valproic acid induces neuronal cell death through a novel calpain-dependent necroptosis pathway.

Bollino D, Balan I, Aurelian L.

J Neurochem. 2015 Apr;133(2):174-86. doi: 10.1111/jnc.13029. Epub 2015 Feb 8.


Creating a "Prosurvival Phenotype" Through Histone Deacetylase Inhibition: Past, Present, and Future.

Halaweish I, Nikolian V, Georgoff P, Li Y, Alam HB.

Shock. 2015 Aug;44 Suppl 1:6-16. doi: 10.1097/SHK.0000000000000319. Review.


Purpurogallin, a natural phenol, attenuates high-mobility group box 1 in subarachnoid hemorrhage induced vasospasm in a rat model.

Chang CZ, Lin CL, Wu SC, Kwan AL.

Int J Vasc Med. 2014;2014:254270. doi: 10.1155/2014/254270. Epub 2014 Nov 17.


Altered behavioral development in Nrf2 knockout mice following early postnatal exposure to valproic acid.

Furnari MA, Saw CL, Kong AN, Wagner GC.

Brain Res Bull. 2014 Oct;109:132-42. doi: 10.1016/j.brainresbull.2014.10.006. Epub 2014 Oct 20.


Phase 1/2 study of valproic acid and short-course radiotherapy plus capecitabine as preoperative treatment in low-moderate risk rectal cancer-V-shoRT-R3 (Valproic acid--short Radiotherapy--rectum 3rd trial).

Avallone A, Piccirillo MC, Delrio P, Pecori B, Di Gennaro E, Aloj L, Tatangelo F, D'Angelo V, Granata C, Cavalcanti E, Maurea N, Maiolino P, Bianco F, Montano M, Silvestro L, Terranova Barberio M, Roca MS, Di Maio M, Marone P, Botti G, Petrillo A, Daniele G, Lastoria S, Iaffaioli VR, Romano G, Caracò C, Muto P, Gallo C, Perrone F, Budillon A.

BMC Cancer. 2014 Nov 24;14:875. doi: 10.1186/1471-2407-14-875.


Acetylation preserves retinal ganglion cell structure and function in a chronic model of ocular hypertension.

Alsarraf O, Fan J, Dahrouj M, Chou CJ, Yates PW, Crosson CE.

Invest Ophthalmol Vis Sci. 2014 Oct 30;55(11):7486-93. doi: 10.1167/iovs.14-14792.


Changing the selectivity of p300 by acetyl-CoA modulation of histone acetylation.

Henry RA, Kuo YM, Bhattacharjee V, Yen TJ, Andrews AJ.

ACS Chem Biol. 2015 Jan 16;10(1):146-56. doi: 10.1021/cb500726b. Epub 2014 Nov 6.

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