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Results: 20

1.

Discovery of HDAC Inhibitors That Lack an Active Site Zn(2+)-Binding Functional Group.

Vickers CJ, Olsen CA, Leman LJ, Ghadiri MR.

ACS Med Chem Lett. 2012 Apr 26;3(6):505-8. doi: 10.1021/ml300081u. eCollection 2012 Jun 14.

PMID:
24900500
[PubMed]
Free PMC Article
2.

STAT5 acetylation: Mechanisms and consequences for immunological control and leukemogenesis.

Kosan C, Ginter T, Heinzel T, Krämer OH.

JAKSTAT. 2013 Oct 1;2(4):e26102. doi: 10.4161/jkst.26102. Epub 2013 Aug 19. Review.

PMID:
24416653
[PubMed]
Free PMC Article
3.

Toward isozyme-selective inhibitors of histone deacetylase as therapeutic agents for the treatment of cancer.

Ononye SN, van Heyst M, Falcone EM, Anderson AC, Wright DL.

Pharm Pat Anal. 2012 May;1(2):207-21.

PMID:
24163736
[PubMed - in process]
Free PMC Article
4.

Class I HDAC imaging using [ (3)H]CI-994 autoradiography.

Wang Y, Zhang YL, Hennig K, Gale JP, Hong Y, Cha A, Riley M, Wagner F, Haggarty SJ, Holson E, Hooker J.

Epigenetics. 2013 Jul;8(7):756-64. doi: 10.4161/epi.25202. Epub 2013 Jun 11.

PMID:
23803584
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Selective HDAC1/HDAC2 inhibitors induce neuroblastoma differentiation.

Frumm SM, Fan ZP, Ross KN, Duvall JR, Gupta S, VerPlank L, Suh BC, Holson E, Wagner FF, Smith WB, Paranal RM, Bassil CF, Qi J, Roti G, Kung AL, Bradner JE, Tolliday N, Stegmaier K.

Chem Biol. 2013 May 23;20(5):713-25. doi: 10.1016/j.chembiol.2013.03.020.

PMID:
23706636
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Interplay between coagulation and vascular inflammation in sickle cell disease.

Sparkenbaugh E, Pawlinski R.

Br J Haematol. 2013 Jul;162(1):3-14. doi: 10.1111/bjh.12336. Epub 2013 Apr 18. Review.

PMID:
23593937
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Corepressor-dependent silencing of fetal hemoglobin expression by BCL11A.

Xu J, Bauer DE, Kerenyi MA, Vo TD, Hou S, Hsu YJ, Yao H, Trowbridge JJ, Mandel G, Orkin SH.

Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6518-23. doi: 10.1073/pnas.1303976110. Epub 2013 Apr 1.

PMID:
23576758
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Stimulation of histone deacetylase activity by metabolites of intermediary metabolism.

Vogelauer M, Krall AS, McBrian MA, Li JY, Kurdistani SK.

J Biol Chem. 2012 Sep 14;287(38):32006-16. doi: 10.1074/jbc.M112.362467. Epub 2012 Jul 20.

PMID:
22822071
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

FK228 Analogues Induce Fetal Hemoglobin in Human Erythroid Progenitors.

Makala L, Di Maro S, Lou TF, Sivanand S, Ahn JM, Pace BS.

Anemia. 2012;2012:428137. doi: 10.1155/2012/428137. Epub 2012 May 14.

PMID:
22655179
[PubMed]
Free PMC Article
10.

Generation of a genomic reporter assay system for analysis of γ- and β-globin gene regulation.

Chan KS, Xu J, Wardan H, McColl B, Orkin S, Vadolas J.

FASEB J. 2012 Apr;26(4):1736-44. doi: 10.1096/fj.11-199356. Epub 2012 Jan 20.

PMID:
22267339
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Genetic and proteomic approaches to identify cancer drug targets.

Roti G, Stegmaier K.

Br J Cancer. 2012 Jan 17;106(2):254-61. doi: 10.1038/bjc.2011.543. Epub 2011 Dec 13. Review.

PMID:
22166799
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Correction of sickle cell disease in adult mice by interference with fetal hemoglobin silencing.

Xu J, Peng C, Sankaran VG, Shao Z, Esrick EB, Chong BG, Ippolito GC, Fujiwara Y, Ebert BL, Tucker PW, Orkin SH.

Science. 2011 Nov 18;334(6058):993-6. doi: 10.1126/science.1211053. Epub 2011 Oct 13.

PMID:
21998251
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

A functional element necessary for fetal hemoglobin silencing.

Sankaran VG, Xu J, Byron R, Greisman HA, Fisher C, Weatherall DJ, Sabath DE, Groudine M, Orkin SH, Premawardhena A, Bender MA.

N Engl J Med. 2011 Sep 1;365(9):807-14. doi: 10.1056/NEJMoa1103070.

PMID:
21879898
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Fetal hemoglobin in sickle cell anemia.

Akinsheye I, Alsultan A, Solovieff N, Ngo D, Baldwin CT, Sebastiani P, Chui DH, Steinberg MH.

Blood. 2011 Jul 7;118(1):19-27. doi: 10.1182/blood-2011-03-325258. Epub 2011 Apr 13. Review.

PMID:
21490337
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Role of natural product diversity in chemical biology.

Hong J.

Curr Opin Chem Biol. 2011 Jun;15(3):350-4. doi: 10.1016/j.cbpa.2011.03.004. Epub 2011 Apr 12. Review.

PMID:
21489856
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Diamond Blackfan anemia treatment: past, present, and future.

Narla A, Vlachos A, Nathan DG.

Semin Hematol. 2011 Apr;48(2):117-23. doi: 10.1053/j.seminhematol.2011.01.004. Review.

PMID:
21435508
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Transcriptional regulation of fetal to adult hemoglobin switching: new therapeutic opportunities.

Wilber A, Nienhuis AW, Persons DA.

Blood. 2011 Apr 14;117(15):3945-53. doi: 10.1182/blood-2010-11-316893. Epub 2011 Feb 14. Review.

PMID:
21321359
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Histone deacetylase (HDAC) inhibition as a novel treatment for diabetes mellitus.

Christensen DP, Dahllöf M, Lundh M, Rasmussen DN, Nielsen MD, Billestrup N, Grunnet LG, Mandrup-Poulsen T.

Mol Med. 2011 May-Jun;17(5-6):378-90. doi: 10.2119/molmed.2011.00021. Epub 2011 Jan 25. Review.

PMID:
21274504
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Update on fetal hemoglobin gene regulation in hemoglobinopathies.

Bauer DE, Orkin SH.

Curr Opin Pediatr. 2011 Feb;23(1):1-8. doi: 10.1097/MOP.0b013e3283420fd0. Review.

PMID:
21157349
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Histone deacetylase 9 activates gamma-globin gene expression in primary erythroid cells.

Muralidhar SA, Ramakrishnan V, Kalra IS, Li W, Pace BS.

J Biol Chem. 2011 Jan 21;286(3):2343-53. doi: 10.1074/jbc.M110.115725. Epub 2010 Nov 13.

PMID:
21078662
[PubMed - indexed for MEDLINE]
Free PMC Article

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