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Items: 1 to 20 of 46


Could the eIF2α-Independent Translation Be the Achilles Heel of Cancer?

Holcik M.

Front Oncol. 2015 Nov 26;5:264. doi: 10.3389/fonc.2015.00264. eCollection 2015. Review.


Deregulation of Internal Ribosome Entry Site-Mediated p53 Translation in Cancer Cells with Defective p53 Response to DNA Damage.

Halaby MJ, Harris BR, Miskimins WK, Cleary MP, Yang DQ.

Mol Cell Biol. 2015 Dec;35(23):4006-17. doi: 10.1128/MCB.00365-15. Epub 2015 Sep 21.


Cis-regulatory RNA elements that regulate specialized ribosome activity.

Xue S, Barna M.

RNA Biol. 2015;12(10):1083-7. doi: 10.1080/15476286.2015.1085149. Epub 2015 Sep 1.


Translational Control Protein 80 Stimulates IRES-Mediated Translation of p53 mRNA in Response to DNA Damage.

Halaby MJ, Li Y, Harris BR, Jiang S, Miskimins WK, Cleary MP, Yang DQ.

Biomed Res Int. 2015;2015:708158. doi: 10.1155/2015/708158. Epub 2015 Jul 26.


Differential Requirements for eIF4E Dose in Normal Development and Cancer.

Truitt ML, Conn CS, Shi Z, Pang X, Tokuyasu T, Coady AM, Seo Y, Barna M, Ruggero D.

Cell. 2015 Jul 2;162(1):59-71. doi: 10.1016/j.cell.2015.05.049. Epub 2015 Jun 18.


In Vivo Senescence in the Sbds-Deficient Murine Pancreas: Cell-Type Specific Consequences of Translation Insufficiency.

Tourlakis ME, Zhang S, Ball HL, Gandhi R, Liu H, Zhong J, Yuan JS, Guidos CJ, Durie PR, Rommens JM.

PLoS Genet. 2015 Jun 9;11(6):e1005288. doi: 10.1371/journal.pgen.1005288. eCollection 2015 Jun.


Impaired Telomere Maintenance and Decreased Canonical WNT Signaling but Normal Ribosome Biogenesis in Induced Pluripotent Stem Cells from X-Linked Dyskeratosis Congenita Patients.

Gu BW, Apicella M, Mills J, Fan JM, Reeves DA, French D, Podsakoff GM, Bessler M, Mason PJ.

PLoS One. 2015 May 18;10(5):e0127414. doi: 10.1371/journal.pone.0127414. eCollection 2015.


Unraveling the pathogenesis of Hoyeraal-Hreidarsson syndrome, a complex telomere biology disorder.

Glousker G, Touzot F, Revy P, Tzfati Y, Savage SA.

Br J Haematol. 2015 Aug;170(4):457-71. doi: 10.1111/bjh.13442. Epub 2015 May 4. Review.


Ribosomopathies: mechanisms of disease.

Nakhoul H, Ke J, Zhou X, Liao W, Zeng SX, Lu H.

Clin Med Insights Blood Disord. 2014 Aug 14;7:7-16. doi: 10.4137/CMBD.S16952. eCollection 2014. Review.


RNA regulons in Hox 5' UTRs confer ribosome specificity to gene regulation.

Xue S, Tian S, Fujii K, Kladwang W, Das R, Barna M.

Nature. 2015 Jan 1;517(7532):33-8. doi: 10.1038/nature14010. Epub 2014 Nov 19.


A novel Bcr-Abl-mTOR-eIF4A axis regulates IRES-mediated translation of LEF-1.

Tsai BP, Jimenez J, Lim S, Fitzgerald KD, Zhang M, Chuah CT, Axelrod H, Wilson L, Ong ST, Semler BL, Waterman ML.

Open Biol. 2014 Nov;4(11):140180. doi: 10.1098/rsob.140180.


Small RNAs with big implications: new insights into H/ACA snoRNA function and their role in human disease.

McMahon M, Contreras A, Ruggero D.

Wiley Interdiscip Rev RNA. 2015 Mar-Apr;6(2):173-89. doi: 10.1002/wrna.1266. Epub 2014 Oct 31. Review.


Cellular differences in protein synthesis regulate tissue homeostasis.

Buszczak M, Signer RA, Morrison SJ.

Cell. 2014 Oct 9;159(2):242-51. doi: 10.1016/j.cell.2014.09.016. Review.


Marrow failure: a window into ribosome biology.

Ruggero D, Shimamura A.

Blood. 2014 Oct 30;124(18):2784-92. doi: 10.1182/blood-2014-04-526301. Epub 2014 Sep 18. Review.


Andrographolide induces apoptosis of C6 glioma cells via the ERK-p53-caspase 7-PARP pathway.

Yang SH, Wang SM, Syu JP, Chen Y, Wang SD, Peng YS, Kuo MF, Kung HN.

Biomed Res Int. 2014;2014:312847. doi: 10.1155/2014/312847. Epub 2014 Aug 5.


Acute dyskerin depletion triggers cellular senescence and renders osteosarcoma cells resistant to genotoxic stress-induced apoptosis.

Lin P, Mobasher ME, Alawi F.

Biochem Biophys Res Commun. 2014 Apr 18;446(4):1268-75. doi: 10.1016/j.bbrc.2014.03.114. Epub 2014 Mar 29.


Down-regulation of eIF4GII by miR-520c-3p represses diffuse large B cell lymphoma development.

Mazan-Mamczarz K, Zhao XF, Dai B, Steinhardt JJ, Peroutka RJ, Berk KL, Landon AL, Sadowska M, Zhang Y, Lehrmann E, Becker KG, Shaknovich R, Liu Z, Gartenhaus RB.

PLoS Genet. 2014 Jan 30;10(1):e1004105. doi: 10.1371/journal.pgen.1004105. eCollection 2014 Jan.


Secreted hCLCA1 is a signaling molecule that activates airway macrophages.

Ching JC, Lobanova L, Loewen ME.

PLoS One. 2013 Dec 12;8(12):e83130. doi: 10.1371/journal.pone.0083130. eCollection 2013.


eIF2α phosphorylation bypasses premature senescence caused by oxidative stress and pro-oxidant antitumor therapies.

Rajesh K, Papadakis AI, Kazimierczak U, Peidis P, Wang S, Ferbeyre G, Kaufman RJ, Koromilas AE.

Aging (Albany NY). 2013 Dec;5(12):884-901.


Investigating Myc-dependent translational regulation in normal and cancer cells.

Cunningham JT, Pourdehnad M, Stumpf CR, Ruggero D.

Methods Mol Biol. 2013;1012:201-12. doi: 10.1007/978-1-62703-429-6_13.

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