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Results: 18

Cited In for PubMed (Select 20416324)


Retroviral Integrase Structure and DNA Recombination Mechanism.

Engelman A, Cherepanov P.

Microbiol Spectr. 2014;2(6):1-22.


The mechanism of H171T resistance reveals the importance of Nδ-protonated His171 for the binding of allosteric inhibitor BI-D to HIV-1 integrase.

Slaughter A, Jurado KA, Deng N, Feng L, Kessl JJ, Shkriabai N, Larue RC, Fadel HJ, Patel PA, Jena N, Fuchs JR, Poeschla E, Levy RM, Engelman A, Kvaratskhelia M.

Retrovirology. 2014 Nov 25;11(1):100. doi: 10.1186/s12977-014-0100-1.


A critical role of the C-terminal segment for allosteric inhibitor-induced aberrant multimerization of HIV-1 integrase.

Shkriabai N, Dharmarajan V, Slaughter A, Kessl JJ, Larue RC, Feng L, Fuchs JR, Griffin PR, Kvaratskhelia M.

J Biol Chem. 2014 Sep 19;289(38):26430-40. doi: 10.1074/jbc.M114.589572. Epub 2014 Aug 12.


A new class of multimerization selective inhibitors of HIV-1 integrase.

Sharma A, Slaughter A, Jena N, Feng L, Kessl JJ, Fadel HJ, Malani N, Male F, Wu L, Poeschla E, Bushman FD, Fuchs JR, Kvaratskhelia M.

PLoS Pathog. 2014 May 29;10(5):e1004171. doi: 10.1371/journal.ppat.1004171. eCollection 2014 May.


Rous sarcoma virus synaptic complex capable of concerted integration is kinetically trapped by human immunodeficiency virus integrase strand transfer inhibitors.

Pandey KK, Bera S, Korolev S, Campbell M, Yin Z, Aihara H, Grandgenett DP.

J Biol Chem. 2014 Jul 11;289(28):19648-58. doi: 10.1074/jbc.M114.573311. Epub 2014 May 28.


Multimodal mechanism of action of allosteric HIV-1 integrase inhibitors.

Jurado KA, Engelman A.

Expert Rev Mol Med. 2013 Nov 26;15:e14. doi: 10.1017/erm.2013.15. Review.


Structural and functional insights into foamy viral integrase.

Hossain MA, Ali MK, Shin CG.

Viruses. 2013 Jul 18;5(7):1850-66. doi: 10.3390/v5071850. Review.


Dialysis purification of integrase-DNA complexes provides high-resolution atomic force microscopy images: dimeric recombinant HIV-1 integrase binding and specific looping on DNA.

Tsuruyama T, Nakai T, Ohmori R, Ozeki M, Tamaki K, Yoshikawa K.

PLoS One. 2013;8(1):e53572. doi: 10.1371/journal.pone.0053572. Epub 2013 Jan 14.


Retroviral integrase proteins and HIV-1 DNA integration.

Krishnan L, Engelman A.

J Biol Chem. 2012 Nov 30;287(49):40858-66. doi: 10.1074/jbc.R112.397760. Epub 2012 Oct 5. Review.


The molecular biology of HIV integrase.

Craigie R.

Future Virol. 2012 Jul;7(7):679-686.


A protein ballet around the viral genome orchestrated by HIV-1 reverse transcriptase leads to an architectural switch: from nucleocapsid-condensed RNA to Vpr-bridged DNA.

Lyonnais S, Gorelick RJ, Heniche-Boukhalfa F, Bouaziz S, Parissi V, Mouscadet JF, Restle T, Gatell JM, Le Cam E, Mirambeau G.

Virus Res. 2013 Feb;171(2):287-303. doi: 10.1016/j.virusres.2012.09.008. Epub 2012 Sep 24.


Solution conformations of prototype foamy virus integrase and its stable synaptic complex with U5 viral DNA.

Gupta K, Curtis JE, Krueger S, Hwang Y, Cherepanov P, Bushman FD, Van Duyne GD.

Structure. 2012 Nov 7;20(11):1918-28. doi: 10.1016/j.str.2012.08.023. Epub 2012 Sep 20.


DNA requirements for assembly and stability of HIV-1 intasomes.

Li M, Ivanov V, Mizuuchi M, Mizuuchi K, Craigie R.

Protein Sci. 2012 Feb;21(2):249-57. doi: 10.1002/pro.2010.


FRET analysis reveals distinct conformations of IN tetramers in the presence of viral DNA or LEDGF/p75.

Kessl JJ, Li M, Ignatov M, Shkriabai N, Eidahl JO, Feng L, Musier-Forsyth K, Craigie R, Kvaratskhelia M.

Nucleic Acids Res. 2011 Nov 1;39(20):9009-22. doi: 10.1093/nar/gkr581. Epub 2011 Jul 19.


HIV-1 integrase strand transfer inhibitors stabilize an integrase-single blunt-ended DNA complex.

Bera S, Pandey KK, Vora AC, Grandgenett DP.

J Mol Biol. 2011 Jul 29;410(5):831-46. doi: 10.1016/j.jmb.2011.01.043. Epub 2011 Feb 3.


Structural biology of retroviral DNA integration.

Li X, Krishnan L, Cherepanov P, Engelman A.

Virology. 2011 Mar 15;411(2):194-205. doi: 10.1016/j.virol.2010.12.008. Epub 2011 Jan 8. Review.


Features, processing states, and heterologous protein interactions in the modulation of the retroviral nucleocapsid protein function.

Mirambeau G, Lyonnais S, Gorelick RJ.

RNA Biol. 2010 Nov-Dec;7(6):724-34. Epub 2010 Nov 1. Review.


Molecular mechanisms of retroviral integrase inhibition and the evolution of viral resistance.

Hare S, Vos AM, Clayton RF, Thuring JW, Cummings MD, Cherepanov P.

Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):20057-62. doi: 10.1073/pnas.1010246107. Epub 2010 Oct 28.

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