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Items: 12

1.

Regulation of PXR and CAR by protein-protein interaction and signaling crosstalk.

Oladimeji P, Cui H, Zhang C, Chen T.

Expert Opin Drug Metab Toxicol. 2016 Sep;12(9):997-1010. doi: 10.1080/17425255.2016.1201069. Epub 2016 Jun 23.

PMID:
27295009
2.

Small-molecule modulators of PXR and CAR.

Chai SC, Cherian MT, Wang YM, Chen T.

Biochim Biophys Acta. 2016 Sep;1859(9):1141-54. doi: 10.1016/j.bbagrm.2016.02.013. Epub 2016 Feb 24.

PMID:
26921498
3.

Gadd45b is a novel mediator of neuronal apoptosis in ischemic stroke.

Liu B, Zhang YH, Jiang Y, Li LL, Chen Q, He GQ, Tan XD, Li CQ.

Int J Biol Sci. 2015 Feb 8;11(3):353-60. doi: 10.7150/ijbs.9813. eCollection 2015.

4.

Targeting xenobiotic receptors PXR and CAR in human diseases.

Banerjee M, Robbins D, Chen T.

Drug Discov Today. 2015 May;20(5):618-28. doi: 10.1016/j.drudis.2014.11.011. Epub 2014 Nov 20. Review.

5.

Flame retardant BDE-47 effectively activates nuclear receptor CAR in human primary hepatocytes.

Sueyoshi T, Li L, Wang H, Moore R, Kodavanti PR, Lehmler HJ, Negishi M, Birnbaum LS.

Toxicol Sci. 2014 Feb;137(2):292-302. doi: 10.1093/toxsci/kft243. Epub 2013 Nov 11.

6.

GADD45β mediates p53 protein degradation via Src/PP2A/MDM2 pathway upon arsenite treatment.

Yu Y, Huang H, Li J, Zhang J, Gao J, Lu B, Huang C.

Cell Death Dis. 2013 May 16;4:e637. doi: 10.1038/cddis.2013.162.

7.

Xenobiotic-induced hepatocyte proliferation associated with constitutive active/androstane receptor (CAR) or peroxisome proliferator-activated receptor α (PPARα) is enhanced by pregnane X receptor (PXR) activation in mice.

Shizu R, Benoki S, Numakura Y, Kodama S, Miyata M, Yamazoe Y, Yoshinari K.

PLoS One. 2013 Apr 23;8(4):e61802. doi: 10.1371/journal.pone.0061802. Print 2013.

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Pregnane X receptor PXR activates the GADD45beta gene, eliciting the p38 MAPK signal and cell migration.

Kodama S, Negishi M.

J Biol Chem. 2011 Feb 4;286(5):3570-8. doi: 10.1074/jbc.M110.179812. Epub 2010 Dec 2.

12.

Xenobiotic metabolism, disposition, and regulation by receptors: from biochemical phenomenon to predictors of major toxicities.

Omiecinski CJ, Vanden Heuvel JP, Perdew GH, Peters JM.

Toxicol Sci. 2011 Mar;120 Suppl 1:S49-75. doi: 10.1093/toxsci/kfq338. Epub 2010 Nov 8. Review.

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