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Rescued expression of WIF-1 in gallbladder cancer inhibits tumor growth and induces tumor cell apoptosis with altered expression of proteins.

Huang Y, Du Q, Wu W, She F, Chen Y.

Mol Med Rep. 2016 Sep;14(3):2573-81. doi: 10.3892/mmr.2016.5532. Epub 2016 Jul 19.


Wnt/β-catenin signaling plays an ever-expanding role in stem cell self-renewal, tumorigenesis and cancer chemoresistance.

Mohammed MK, Shao C, Wang J, Wei Q, Wang X, Collier Z, Tang S, Liu H, Zhang F, Huang J, Guo D, Lu M, Liu F, Liu J, Ma C, Shi LL, Athiviraham A, He TC, Lee MJ.

Genes Dis. 2016 Mar;3(1):11-40. Epub 2016 Jan 14.


The evolving roles of canonical WNT signaling in stem cells and tumorigenesis: implications in targeted cancer therapies.

Yang K, Wang X, Zhang H, Wang Z, Nan G, Li Y, Zhang F, Mohammed MK, Haydon RC, Luu HH, Bi Y, He TC.

Lab Invest. 2016 Feb;96(2):116-36. doi: 10.1038/labinvest.2015.144. Epub 2015 Nov 30.


Osteosarcoma Genetics and Epigenetics: Emerging Biology and Candidate Therapies.

Morrow JJ, Khanna C.

Crit Rev Oncog. 2015;20(3-4):173-97. Review.


Role of Wnt Inhibitory Factor-1 in Inhibition of Bisdemethoxycurcumin Mediated Epithelial-to-Mesenchymal Transition in Highly Metastatic Lung Cancer 95D Cells.

Xu JH, Yang HP, Zhou XD, Wang HJ, Gong L, Tang CL.

Chin Med J (Engl). 2015 May 20;128(10):1376-83. doi: 10.4103/0366-6999.156795.


Dietary compound isoliquiritigenin prevents mammary carcinogenesis by inhibiting breast cancer stem cells through WIF1 demethylation.

Wang N, Wang Z, Wang Y, Xie X, Shen J, Peng C, You J, Peng F, Tang H, Guan X, Chen J.

Oncotarget. 2015;6(12):9854-76.


Neuropilin-2 expression is inhibited by secreted Wnt antagonists and its down-regulation is associated with reduced tumor growth and metastasis in osteosarcoma.

Ji T, Guo Y, Kim K, McQueen P, Ghaffar S, Christ A, Lin C, Eskander R, Zi X, Hoang BH.

Mol Cancer. 2015 Apr 17;14:86. doi: 10.1186/s12943-015-0359-4.


Anoikis-resistant subpopulations of human osteosarcoma display significant chemoresistance and are sensitive to targeted epigenetic therapies predicted by expression profiling.

Foley JM, Scholten DJ 2nd, Monks NR, Cherba D, Monsma DJ, Davidson P, Dylewski D, Dykema K, Winn ME, Steensma MR.

J Transl Med. 2015 Apr 2;13:110. doi: 10.1186/s12967-015-0466-4.


Targeting CDK11 in osteosarcoma cells using the CRISPR-Cas9 system.

Feng Y, Sassi S, Shen JK, Yang X, Gao Y, Osaka E, Zhang J, Yang S, Yang C, Mankin HJ, Hornicek FJ, Duan Z.

J Orthop Res. 2015 Feb;33(2):199-207. doi: 10.1002/jor.22745. Epub 2014 Oct 27.


Down regulation of Wnt signaling mitigates hypoxia-induced chemoresistance in human osteosarcoma cells.

Scholten DJ 2nd, Timmer CM, Peacock JD, Pelle DW, Williams BO, Steensma MR.

PLoS One. 2014 Oct 27;9(10):e111431. doi: 10.1371/journal.pone.0111431. eCollection 2014.


Lung cancer transcriptomes refined with laser capture microdissection.

Lin J, Marquardt G, Mullapudi N, Wang T, Han W, Shi M, Keller S, Zhu C, Locker J, Spivack SD.

Am J Pathol. 2014 Nov;184(11):2868-84. doi: 10.1016/j.ajpath.2014.06.028. Epub 2014 Aug 14.


Human Sarcoma growth is sensitive to small-molecule mediated AXIN stabilization.

De Robertis A, Mennillo F, Rossi M, Valensin S, Tunici P, Mori E, Caradonna N, Varrone M, Salerno M.

PLoS One. 2014 May 19;9(5):e97847. doi: 10.1371/journal.pone.0097847. eCollection 2014.


The tankyrase-specific inhibitor JW74 affects cell cycle progression and induces apoptosis and differentiation in osteosarcoma cell lines.

Stratford EW, Daffinrud J, Munthe E, Castro R, Waaler J, Krauss S, Myklebost O.

Cancer Med. 2014 Feb;3(1):36-46. doi: 10.1002/cam4.170. Epub 2013 Dec 17.


The anti-tumor effect of shikonin on osteosarcoma by inducing RIP1 and RIP3 dependent necroptosis.

Fu Z, Deng B, Liao Y, Shan L, Yin F, Wang Z, Zeng H, Zuo D, Hua Y, Cai Z.

BMC Cancer. 2013 Dec 6;13:580. doi: 10.1186/1471-2407-13-580.


β-Catenin transcriptional activity is minimal in canine osteosarcoma and its targeted inhibition results in minimal changes to cell line behaviour.

Piskun CM, Stein TJ.

Vet Comp Oncol. 2016 Jun;14(2):e4-e16. doi: 10.1111/vco.12077. Epub 2013 Nov 21.


Protein kinase C epsilon and genetic networks in osteosarcoma metastasis.

Goudarzi A, Gokgoz N, Gill M, Pinnaduwage D, Merico D, Wunder JS, Andrulis IL.

Cancers (Basel). 2013 Apr 8;5(2):372-403. doi: 10.3390/cancers5020372.


Surface proteomic analysis of osteosarcoma identifies EPHA2 as receptor for targeted drug delivery.

Posthumadeboer J, Piersma SR, Pham TV, van Egmond PW, Knol JC, Cleton-Jansen AM, van Geer MA, van Beusechem VW, Kaspers GJ, van Royen BJ, Jiménez CR, Helder MN.

Br J Cancer. 2013 Oct 15;109(8):2142-54. doi: 10.1038/bjc.2013.578. Epub 2013 Sep 24.


Understanding the Biology of Bone Sarcoma from Early Initiating Events through Late Events in Metastasis and Disease Progression.

Zhu L, McManus MM, Hughes DP.

Front Oncol. 2013 Sep 17;3:230. doi: 10.3389/fonc.2013.00230. Review.


Flavokawain B, a kava chalcone, inhibits growth of human osteosarcoma cells through G2/M cell cycle arrest and apoptosis.

Ji T, Lin C, Krill LS, Eskander R, Guo Y, Zi X, Hoang BH.

Mol Cancer. 2013 Jun 10;12:55. doi: 10.1186/1476-4598-12-55.

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