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Design and Synthesis of Molecular Scaffolds with Anti-infective Activity.

Liu J, Bedell TA, West JG, Sorensen EJ.

Tetrahedron. 2016 Jun 23;72(25):3579-3592. Epub 2016 Jan 28. No abstract available.


Zebrafish behavioral profiling identifies multitarget antipsychotic-like compounds.

Bruni G, Rennekamp AJ, Velenich A, McCarroll M, Gendelev L, Fertsch E, Taylor J, Lakhani P, Lensen D, Evron T, Lorello PJ, Huang XP, Kolczewski S, Carey G, Caldarone BJ, Prinssen E, Roth BL, Keiser MJ, Peterson RT, Kokel D.

Nat Chem Biol. 2016 Jul;12(7):559-66. doi: 10.1038/nchembio.2097. Epub 2016 May 30.


Data integration to prioritize drugs using genomics and curated data.

Louhimo R, Laakso M, Belitskin D, Klefström J, Lehtonen R, Hautaniemi S.

BioData Min. 2016 May 26;9:21. doi: 10.1186/s13040-016-0097-1. eCollection 2016.


DrugGenEx-Net: a novel computational platform for systems pharmacology and gene expression-based drug repurposing.

Issa NT, Kruger J, Wathieu H, Raja R, Byers SW, Dakshanamurthy S.

BMC Bioinformatics. 2016 May 5;17(1):202. doi: 10.1186/s12859-016-1065-y.


Ion channels find a pathway for therapeutic success.

Garcia ML, Kaczorowski GJ.

Proc Natl Acad Sci U S A. 2016 May 17;113(20):5472-4. doi: 10.1073/pnas.1605669113. Epub 2016 May 4. No abstract available.


A Laminated Microfluidic Device for Comprehensive Preclinical Testing in the Drug ADME Process.

An F, Qu Y, Luo Y, Fang N, Liu Y, Gao Z, Zhao W, Lin B.

Sci Rep. 2016 Apr 28;6:25022. doi: 10.1038/srep25022.


Changing R&D models in research-based pharmaceutical companies.

Schuhmacher A, Gassmann O, Hinder M.

J Transl Med. 2016 Apr 27;14(1):105. doi: 10.1186/s12967-016-0838-4. Review.


Rapid Discovery and Structure-Activity Relationships of Pyrazolopyrimidines That Potently Suppress Breast Cancer Cell Growth via SRC Kinase Inhibition with Exceptional Selectivity over ABL Kinase.

Fraser C, Dawson JC, Dowling R, Houston DR, Weiss JT, Munro AF, Muir M, Harrington L, Webster SP, Frame MC, Brunton VG, Patton EE, Carragher NO, Unciti-Broceta A.

J Med Chem. 2016 May 26;59(10):4697-710. doi: 10.1021/acs.jmedchem.6b00065. Epub 2016 May 4.


Is there a role of synovial biopsy in drug development?

Filkova M, Cope A, Mant T, Galloway J.

BMC Musculoskelet Disord. 2016 Apr 19;17(1):172. doi: 10.1186/s12891-016-1028-5.


In silico methods for drug repurposing and pharmacology.

Hodos RA, Kidd BA, Shameer K, Readhead BP, Dudley JT.

Wiley Interdiscip Rev Syst Biol Med. 2016 May;8(3):186-210. doi: 10.1002/wsbm.1337. Epub 2016 Apr 15. Review.


Genetic Polymorphisms Affect Mouse and Human Trace Amine-Associated Receptor 1 Function.

Shi X, Walter NA, Harkness JH, Neve KA, Williams RW, Lu L, Belknap JK, Eshleman AJ, Phillips TJ, Janowsky A.

PLoS One. 2016 Mar 31;11(3):e0152581. doi: 10.1371/journal.pone.0152581. eCollection 2016.


The ethics of animal research: a survey of the public and scientists in North America.

Joffe AR, Bara M, Anton N, Nobis N.

BMC Med Ethics. 2016 Mar 29;17:17. doi: 10.1186/s12910-016-0100-x.


Functional genetics-directed identification of novel pharmacological inhibitors of FAS- and TNF-dependent apoptosis that protect mice from acute liver failure.

Komarov AP, Komarova EA, Green K, Novototskaya LR, Baker PS, Eroshkin A, Osterman AL, Chenchick AA, Frangou C, Gudkov AV.

Cell Death Dis. 2016 Mar 17;7:e2145. doi: 10.1038/cddis.2016.45.


DASPfind: new efficient method to predict drug-target interactions.

Ba-Alawi W, Soufan O, Essack M, Kalnis P, Bajic VB.

J Cheminform. 2016 Mar 16;8:15. doi: 10.1186/s13321-016-0128-4. eCollection 2016.


A Perspective on Implementing a Quantitative Systems Pharmacology Platform for Drug Discovery and the Advancement of Personalized Medicine.

Stern AM, Schurdak ME, Bahar I, Berg JM, Taylor DL.

J Biomol Screen. 2016 Jul;21(6):521-34. doi: 10.1177/1087057116635818. Epub 2016 Mar 8.


Repositioning tolcapone as a potent inhibitor of transthyretin amyloidogenesis and associated cellular toxicity.

Sant'Anna R, Gallego P, Robinson LZ, Pereira-Henriques A, Ferreira N, Pinheiro F, Esperante S, Pallares I, Huertas O, Almeida MR, Reixach N, Insa R, Velazquez-Campoy A, Reverter D, Reig N, Ventura S.

Nat Commun. 2016 Feb 23;7:10787. doi: 10.1038/ncomms10787.


Managing risks in drug discovery: reproducibility of published findings.

Kannt A, Wieland T.

Naunyn Schmiedebergs Arch Pharmacol. 2016 Apr;389(4):353-60. doi: 10.1007/s00210-016-1216-8. Epub 2016 Feb 17.


When Quality Beats Quantity: Decision Theory, Drug Discovery, and the Reproducibility Crisis.

Scannell JW, Bosley J.

PLoS One. 2016 Feb 10;11(2):e0147215. doi: 10.1371/journal.pone.0147215. eCollection 2016.


Stimulated Raman scattering microscopy: an emerging tool for drug discovery.

Tipping WJ, Lee M, Serrels A, Brunton VG, Hulme AN.

Chem Soc Rev. 2016 Apr 21;45(8):2075-89. doi: 10.1039/c5cs00693g. Epub 2016 Feb 3.


The Zebrafish as a Tool to Cancer Drug Discovery.

Huiting LN, Laroche F, Feng H.

Austin J Pharmacol Ther. 2015;3(2):1069. Epub 2015 May 4.

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