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Results: 1 to 20 of 179

1.

New developments in the treatment of metastatic melanoma - role of dabrafenib-trametinib combination therapy.

Luke JJ, Ott PA.

Drug Healthc Patient Saf. 2014 Jun 24;6:77-88. doi: 10.2147/DHPS.S39568. eCollection 2014. Review.

PMID:
25018652
[PubMed]
Free PMC Article
2.

Photoactivated Localization Microscopy with Bimolecular Fluorescence Complementation (BiFC-PALM) for Nanoscale Imaging of Protein-Protein Interactions in Cells.

Nickerson A, Huang T, Lin LJ, Nan X.

PLoS One. 2014 Jun 25;9(6):e100589. doi: 10.1371/journal.pone.0100589. eCollection 2014.

PMID:
24963703
[PubMed - in process]
Free PMC Article
3.

Insights into the molecular mechanism of glucose metabolism regulation under stress in chicken skeletal muscle tissues.

Liu W, Zhao J.

Saudi J Biol Sci. 2014 Jul;21(3):197-203. doi: 10.1016/j.sjbs.2014.01.005. Epub 2014 Feb 4. Review.

PMID:
24955006
[PubMed]
Free PMC Article
4.

Pyrazolopyridine Inhibitors of B-Raf(V600E). Part 1: The Development of Selective, Orally Bioavailable, and Efficacious Inhibitors.

Wenglowsky S, Ren L, Ahrendt KA, Laird ER, Aliagas I, Alicke B, Buckmelter AJ, Choo EF, Dinkel V, Feng B, Gloor SL, Gould SE, Gross S, Gunzner-Toste J, Hansen JD, Hatzivassiliou G, Liu B, Malesky K, Mathieu S, Newhouse B, Raddatz NJ, Ran Y, Rana S, Randolph N, Risom T, Rudolph J, Savage S, Selby LT, Shrag M, Song K, Sturgis HL, Voegtli WC, Wen Z, Willis BS, Woessner RD, Wu WI, Young WB, Grina J.

ACS Med Chem Lett. 2011 Mar 8;2(5):342-7. doi: 10.1021/ml200025q. eCollection 2011 May 12.

PMID:
24900315
[PubMed]
Free PMC Article
5.

Genetic targeting of B-RafV600E affects survival and proliferation and identifies selective agents against BRAF-mutant colorectal cancer cells.

Hirschi B, Gallmeier E, Ziesch A, Marschall M, Kolligs FT.

Mol Cancer. 2014 May 24;13:122. doi: 10.1186/1476-4598-13-122.

PMID:
24885690
[PubMed - in process]
Free PMC Article
6.

Exploration of Type II Binding Mode: A Privileged Approach for Kinase Inhibitor Focused Drug Discovery?

Zhao Z, Wu H, Wang L, Liu Y, Knapp S, Liu Q, Gray NS.

ACS Chem Biol. 2014 Apr 29. [Epub ahead of print]

PMID:
24730530
[PubMed - as supplied by publisher]
Free PMC Article
7.

Disruption of mutated BRAF signaling modulates thyroid cancer phenotype.

Hanly EK, Rajoria S, Darzynkiewicz Z, Zhao H, Suriano R, Tuli N, George AL, Bednarczyk R, Shin EJ, Geliebter J, Tiwari RK.

BMC Res Notes. 2014 Mar 28;7:187. doi: 10.1186/1756-0500-7-187.

PMID:
24673746
[PubMed - in process]
Free PMC Article
8.

Tumor heterogeneity in the clinic: is it a real problem?

Janku F.

Ther Adv Med Oncol. 2014 Mar;6(2):43-51. doi: 10.1177/1758834013517414. Review.

PMID:
24587830
[PubMed]
Free PMC Article
9.

PI3K-AKT-mTOR-signaling and beyond: the complex network in gastroenteropancreatic neuroendocrine neoplasms.

Briest F, Grabowski P.

Theranostics. 2014 Jan 29;4(4):336-65. doi: 10.7150/thno.7851. eCollection 2014. Review.

PMID:
24578720
[PubMed - in process]
Free PMC Article
10.

Targeted therapies in development for non-small cell lung cancer.

Reungwetwattana T, Dy GK.

J Carcinog. 2013 Dec 31;12:22. doi: 10.4103/1477-3163.123972. eCollection 2013. Review.

PMID:
24574860
[PubMed]
Free PMC Article
11.

Targeting the prohibitin scaffold-CRAF kinase interaction in RAS-ERK-driven pancreatic ductal adenocarcinoma.

Luan Z, He Y, Alattar M, Chen Z, He F.

Mol Cancer. 2014 Feb 25;13:38. doi: 10.1186/1476-4598-13-38.

PMID:
24568222
[PubMed - in process]
Free PMC Article
12.

Anticancer activity of combination targeted therapy using cetuximab plus vemurafenib for refractory BRAF (V600E)-mutant metastatic colorectal carcinoma.

Connolly K, Brungs D, Szeto E, Epstein RJ.

Curr Oncol. 2014 Feb;21(1):e151-4. doi: 10.3747/co.21.1661.

PMID:
24523613
[PubMed]
Free PMC Article
13.

Kras as a key oncogene and therapeutic target in pancreatic cancer.

Collins MA, Pasca di Magliano M.

Front Physiol. 2014 Jan 21;4:407. doi: 10.3389/fphys.2013.00407. eCollection 2013. Review.

PMID:
24478710
[PubMed]
Free PMC Article
14.
15.

Phenotypic profiling of Raf inhibitors and mitochondrial toxicity in 3D tissue using biodynamic imaging.

An R, Merrill D, Avramova L, Sturgis J, Tsiper M, Robinson JP, Turek J, Nolte DD.

J Biomol Screen. 2014 Apr;19(4):526-37. doi: 10.1177/1087057113516674. Epub 2013 Dec 20.

PMID:
24361645
[PubMed - in process]
Free PMC Article
16.

Biologics in dermatology.

Chandler D, Bewley A.

Pharmaceuticals (Basel). 2013 Apr 17;6(4):557-78. doi: 10.3390/ph6040557.

PMID:
24276125
[PubMed]
Free PMC Article
17.

Mek inhibition results in marked antitumor activity against metastatic melanoma patient-derived melanospheres and in melanosphere-generated xenografts.

Sette G, Fecchi K, Salvati V, Lotti F, Pilozzi E, Duranti E, Biffoni M, Pagliuca A, Martinetti D, Memeo L, Milella M, De Maria R, Eramo A.

J Exp Clin Cancer Res. 2013 Nov 16;32:91. doi: 10.1186/1756-9966-32-91.

PMID:
24238212
[PubMed - in process]
Free PMC Article
18.

BRAF inhibitors suppress apoptosis through off-target inhibition of JNK signaling.

Vin H, Ojeda SS, Ching G, Leung ML, Chitsazzadeh V, Dwyer DW, Adelmann CH, Restrepo M, Richards KN, Stewart LR, Du L, Ferguson SB, Chakravarti D, Ehrenreiter K, Baccarini M, Ruggieri R, Curry JL, Kim KB, Ciurea AM, Duvic M, Prieto VG, Ullrich SE, Dalby KN, Flores ER, Tsai KY.

Elife (Cambridge). 2013 Nov 5;2:e00969. doi: 10.7554/eLife.00969.

PMID:
24192036
[PubMed]
Free PMC Article
19.

Single-molecule superresolution imaging allows quantitative analysis of RAF multimer formation and signaling.

Nan X, Collisson EA, Lewis S, Huang J, Tamg├╝ney TM, Liphardt JT, McCormick F, Gray JW, Chu S.

Proc Natl Acad Sci U S A. 2013 Nov 12;110(46):18519-24. doi: 10.1073/pnas.1318188110. Epub 2013 Oct 24.

PMID:
24158481
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

EGFR-ras-raf signaling in epidermal stem cells: roles in hair follicle development, regeneration, tissue remodeling and epidermal cancers.

Doma E, Rupp C, Baccarini M.

Int J Mol Sci. 2013 Sep 25;14(10):19361-84. doi: 10.3390/ijms141019361. Review.

PMID:
24071938
[PubMed - indexed for MEDLINE]
Free PMC Article

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