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Items: 1 to 20 of 33


Oxidation of the alarmin IL-33 regulates ST2-dependent inflammation.

Cohen ES, Scott IC, Majithiya JB, Rapley L, Kemp BP, England E, Rees DG, Overed-Sayer CL, Woods J, Bond NJ, Veyssier CS, Embrey KJ, Sims DA, Snaith MR, Vousden KA, Strain MD, Chan DT, Carmen S, Huntington CE, Flavell L, Xu J, Popovic B, Brightling CE, Vaughan TJ, Butler R, Lowe DC, Higazi DR, Corkill DJ, May RD, Sleeman MA, Mustelin T.

Nat Commun. 2015 Sep 14;6:8327. doi: 10.1038/ncomms9327.


In vitro glycoengineering of IgG1 and its effect on Fc receptor binding and ADCC activity.

Thomann M, Schlothauer T, Dashivets T, Malik S, Avenal C, Bulau P, Rüger P, Reusch D.

PLoS One. 2015 Aug 12;10(8):e0134949. doi: 10.1371/journal.pone.0134949. eCollection 2015.


Fc glycans of therapeutic antibodies as critical quality attributes.

Reusch D, Tejada ML.

Glycobiology. 2015 Dec;25(12):1325-34. doi: 10.1093/glycob/cwv065. Epub 2015 Aug 11. Review.


Mass spectrometric approaches to study protein structure and interactions in lyophilized powders.

Moorthy BS, Iyer LK, Topp EM.

J Vis Exp. 2015 Apr 14;(98). doi: 10.3791/52503.


The criticality of high-resolution N-linked carbohydrate assays and detailed characterization of antibody effector function in the context of biosimilar development.

Brady LJ, Velayudhan J, Visone DB, Daugherty KC, Bartron JL, Coon M, Cornwall C, Hinckley PJ, Connell-Crowley L.

MAbs. 2015;7(3):562-70. doi: 10.1080/19420862.2015.1016692.


Production of α2,6-sialylated IgG1 in CHO cells.

Raymond C, Robotham A, Spearman M, Butler M, Kelly J, Durocher Y.

MAbs. 2015;7(3):571-83. doi: 10.1080/19420862.2015.1029215.


Hydrogen exchange mass spectrometry reveals protein interfaces and distant dynamic coupling effects during the reversible self-association of an IgG1 monoclonal antibody.

Arora J, Hickey JM, Majumdar R, Esfandiary R, Bishop SM, Samra HS, Middaugh CR, Weis DD, Volkin DB.

MAbs. 2015;7(3):525-39. doi: 10.1080/19420862.2015.1029217.


Correlations between changes in conformational dynamics and physical stability in a mutant IgG1 mAb engineered for extended serum half-life.

Majumdar R, Esfandiary R, Bishop SM, Samra HS, Middaugh CR, Volkin DB, Weis DD.

MAbs. 2015;7(1):84-95. doi: 10.4161/19420862.2014.985494.


A novel approach to investigate the effect of methionine oxidation on pharmacokinetic properties of therapeutic antibodies.

Stracke J, Emrich T, Rueger P, Schlothauer T, Kling L, Knaupp A, Hertenberger H, Wolfert A, Spick C, Lau W, Drabner G, Reiff U, Koll H, Papadimitriou A.

MAbs. 2014;6(5):1229-42. doi: 10.4161/mabs.29601. Epub 2014 Oct 30.


Investigating the interaction between the neonatal Fc receptor and monoclonal antibody variants by hydrogen/deuterium exchange mass spectrometry.

Jensen PF, Larraillet V, Schlothauer T, Kettenberger H, Hilger M, Rand KD.

Mol Cell Proteomics. 2015 Jan;14(1):148-61. doi: 10.1074/mcp.M114.042044. Epub 2014 Nov 6.


Structural and functional characterization of an anti-West Nile virus monoclonal antibody and its single-chain variant produced in glycoengineered plants.

Lai H, He J, Hurtado J, Stahnke J, Fuchs A, Mehlhop E, Gorlatov S, Loos A, Diamond MS, Chen Q.

Plant Biotechnol J. 2014 Oct;12(8):1098-107. doi: 10.1111/pbi.12217. Epub 2014 Jun 29.


Predicting protein aggregation during storage in lyophilized solids using solid state amide hydrogen/deuterium exchange with mass spectrometric analysis (ssHDX-MS).

Moorthy BS, Schultz SG, Kim SG, Topp EM.

Mol Pharm. 2014 Jun 2;11(6):1869-79. doi: 10.1021/mp500005v. Epub 2014 May 21.


Physical stability comparisons of IgG1-Fc variants: effects of N-glycosylation site occupancy and Asp/Gln residues at site Asn 297.

Alsenaidy MA, Okbazghi SZ, Kim JH, Joshi SB, Middaugh CR, Tolbert TJ, Volkin DB.

J Pharm Sci. 2014 Jun;103(6):1613-27. doi: 10.1002/jps.23975. Epub 2014 Apr 16.


Generation and analysis of novel plant-derived antibody-based therapeutic molecules against West Nile virus.

He J, Lai H, Engle M, Gorlatov S, Gruber C, Steinkellner H, Diamond MS, Chen Q.

PLoS One. 2014 Mar 27;9(3):e93541. doi: 10.1371/journal.pone.0093541. eCollection 2014.


Mass spectrometry for the biophysical characterization of therapeutic monoclonal antibodies.

Zhang H, Cui W, Gross ML.

FEBS Lett. 2014 Jan 21;588(2):308-17. doi: 10.1016/j.febslet.2013.11.027. Epub 2013 Nov 26. Review.


Investigating monoclonal antibody aggregation using a combination of H/DX-MS and other biophysical measurements.

Iacob RE, Bou-Assaf GM, Makowski L, Engen JR, Berkowitz SA, Houde D.

J Pharm Sci. 2013 Dec;102(12):4315-29. doi: 10.1002/jps.23754. Epub 2013 Oct 17.


High-throughput biophysical analysis and data visualization of conformational stability of an IgG1 monoclonal antibody after deglycosylation.

Alsenaidy MA, Kim JH, Majumdar R, Weis DD, Joshi SB, Tolbert TJ, Middaugh CR, Volkin DB.

J Pharm Sci. 2013 Nov;102(11):3942-56. doi: 10.1002/jps.23730. Epub 2013 Sep 24.


Development of antibody arrays for monoclonal antibody Higher Order Structure analysis.

Wang X, Li Q, Davies M.

Front Pharmacol. 2013 Aug 21;4:103. doi: 10.3389/fphar.2013.00103. eCollection 2013.


A dual-mode surface display system for the maturation and production of monoclonal antibodies in glyco-engineered Pichia pastoris.

Shaheen HH, Prinz B, Chen MT, Pavoor T, Lin S, Houston-Cummings NR, Moore R, Stadheim TA, Zha D.

PLoS One. 2013 Jul 10;8(7):e70190. doi: 10.1371/journal.pone.0070190. Print 2013.


Rapid and multi-level characterization of trastuzumab using sheathless capillary electrophoresis-tandem mass spectrometry.

Gahoual R, Burr A, Busnel JM, Kuhn L, Hammann P, Beck A, François YN, Leize-Wagner E.

MAbs. 2013 May-Jun;5(3):479-90. doi: 10.4161/mabs.23995. Epub 2013 Apr 5.

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