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Results: 17

1.

Heat shock protein-90 inhibitors enhance antigen expression on melanomas and increase T cell recognition of tumor cells.

Haggerty TJ, Dunn IS, Rose LB, Newton EE, Pandolfi F, Kurnick JT.

PLoS One. 2014 Dec 12;9(12):e114506. doi: 10.1371/journal.pone.0114506. eCollection 2014.

PMID:
25503774
[PubMed - in process]
Free PMC Article
2.

Targeting Plasmodium falciparum Hsp90: Towards Reversing Antimalarial Resistance.

Shahinas D, Folefoc A, Pillai DR.

Pathogens. 2013 Feb 4;2(1):33-54. doi: 10.3390/pathogens2010033. Review.

PMID:
25436880
[PubMed]
Free PMC Article
3.

Chaperone-dependent Neurodegeneration: A Molecular Perspective on Therapeutic Intervention.

Carman A, Kishinevsky S, Koren J 3rd, Lou W, Chiosis G.

J Alzheimers Dis Parkinsonism. 2013 Apr;2013(Suppl 10). pii: 007.

PMID:
25258700
[PubMed]
Free PMC Article
4.

A repurposing strategy for Hsp90 inhibitors demonstrates their potency against filarial nematodes.

Gillan V, O'Neill K, Maitland K, Sverdrup FM, Devaney E.

PLoS Negl Trop Dis. 2014 Feb 13;8(2):e2699. doi: 10.1371/journal.pntd.0002699. eCollection 2014 Feb.

PMID:
24551261
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

A purine analog synergizes with chloroquine (CQ) by targeting Plasmodium falciparum Hsp90 (PfHsp90).

Shahinas D, Folefoc A, Taldone T, Chiosis G, Crandall I, Pillai DR.

PLoS One. 2013 Sep 30;8(9):e75446. doi: 10.1371/journal.pone.0075446. eCollection 2013.

PMID:
24098696
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Molecular chaperone gp96 is a novel therapeutic target of multiple myeloma.

Hua Y, White-Gilbertson S, Kellner J, Rachidi S, Usmani SZ, Chiosis G, Depinho R, Li Z, Liu B.

Clin Cancer Res. 2013 Nov 15;19(22):6242-51. doi: 10.1158/1078-0432.CCR-13-2083. Epub 2013 Sep 27.

PMID:
24077352
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

α7 helix region of αI domain is crucial for integrin binding to endoplasmic reticulum chaperone gp96: a potential therapeutic target for cancer metastasis.

Hong F, Liu B, Chiosis G, Gewirth DT, Li Z.

J Biol Chem. 2013 Jun 21;288(25):18243-8. doi: 10.1074/jbc.M113.468850. Epub 2013 May 13.

PMID:
23671277
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Synthesis and evaluation of cell-permeable biotinylated PU-H71 derivatives as tumor Hsp90 probes.

Taldone T, Rodina A, Dagama Gomes EM, Riolo M, Patel HJ, Alonso-Sabadell R, Zatorska D, Patel MR, Kishinevsky S, Chiosis G.

Beilstein J Org Chem. 2013 Mar 15;9:544-56. doi: 10.3762/bjoc.9.60. Print 2013.

PMID:
23616796
[PubMed]
Free PMC Article
9.

Heat shock protein gp96 regulates Toll-like receptor 9 proteolytic processing and conformational stability.

Brooks JC, Sun W, Chiosis G, Leifer CA.

Biochem Biophys Res Commun. 2012 May 18;421(4):780-4. doi: 10.1016/j.bbrc.2012.04.083. Epub 2012 Apr 23.

PMID:
22554506
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Targeting of KRAS mutant tumors by HSP90 inhibitors involves degradation of STK33.

Azoitei N, Hoffmann CM, Ellegast JM, Ball CR, Obermayer K, Gößele U, Koch B, Faber K, Genze F, Schrader M, Kestler HA, Döhner H, Chiosis G, Glimm H, Fröhling S, Scholl C.

J Exp Med. 2012 Apr 9;209(4):697-711. doi: 10.1084/jem.20111910. Epub 2012 Mar 26.

PMID:
22451720
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Advances in the discovery and development of heat-shock protein 90 inhibitors for cancer treatment.

Patel HJ, Modi S, Chiosis G, Taldone T.

Expert Opin Drug Discov. 2011 May;6(5):559-587.

PMID:
22400044
[PubMed]
Free PMC Article
12.

Advances in the clinical development of heat shock protein 90 (Hsp90) inhibitors in cancers.

Jhaveri K, Taldone T, Modi S, Chiosis G.

Biochim Biophys Acta. 2012 Mar;1823(3):742-55. doi: 10.1016/j.bbamcr.2011.10.008. Epub 2011 Oct 29. Review.

PMID:
22062686
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90.

Moulick K, Ahn JH, Zong H, Rodina A, Cerchietti L, Gomes DaGama EM, Caldas-Lopes E, Beebe K, Perna F, Hatzi K, Vu LP, Zhao X, Zatorska D, Taldone T, Smith-Jones P, Alpaugh M, Gross SS, Pillarsetty N, Ku T, Lewis JS, Larson SM, Levine R, Erdjument-Bromage H, Guzman ML, Nimer SD, Melnick A, Neckers L, Chiosis G.

Nat Chem Biol. 2011 Sep 25;7(11):818-26. doi: 10.1038/nchembio.670.

PMID:
21946277
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Synthesis of purine-scaffold fluorescent probes for heat shock protein 90 with use in flow cytometry and fluorescence microscopy.

Taldone T, Gomes-DaGama EM, Zong H, Sen S, Alpaugh ML, Zatorska D, Alonso-Sabadell R, Guzman ML, Chiosis G.

Bioorg Med Chem Lett. 2011 Sep 15;21(18):5347-52. doi: 10.1016/j.bmcl.2011.07.026. Epub 2011 Jul 14.

PMID:
21802945
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Assay strategies for the discovery and validation of therapeutics targeting Brugia pahangi Hsp90.

Taldone T, Gillan V, Sun W, Rodina A, Patel P, Maitland K, O'Neill K, Chiosis G, Devaney E.

PLoS Negl Trop Dis. 2010 Jun 15;4(6):e714. doi: 10.1371/journal.pntd.0000714.

PMID:
20559560
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Hsp90 inhibitors: a potential treatment for latent EBV infection?

Sun X, Kenney SC.

Cell Cycle. 2010 May;9(9):1665-6. Epub 2010 May 19. No abstract available.

PMID:
20404505
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Heat shock protein 70 (hsp70) as an emerging drug target.

Evans CG, Chang L, Gestwicki JE.

J Med Chem. 2010 Jun 24;53(12):4585-602. doi: 10.1021/jm100054f. Review. No abstract available.

PMID:
20334364
[PubMed - indexed for MEDLINE]
Free PMC Article
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