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Items: 11

1.

How drugs get into cells: tested and testable predictions to help discriminate between transporter-mediated uptake and lipoidal bilayer diffusion.

Kell DB, Oliver SG.

Front Pharmacol. 2014 Oct 31;5:231. doi: 10.3389/fphar.2014.00231. eCollection 2014. Review.

2.

Metformin lowers Ser-129 phosphorylated α-synuclein levels via mTOR-dependent protein phosphatase 2A activation.

Pérez-Revuelta BI, Hettich MM, Ciociaro A, Rotermund C, Kahle PJ, Krauss S, Di Monte DA.

Cell Death Dis. 2014 May 8;5:e1209. doi: 10.1038/cddis.2014.175.

3.

Identification of three novel natural product compounds that activate PXR and CAR and inhibit inflammation.

Kittayaruksakul S, Zhao W, Xu M, Ren S, Lu J, Wang J, Downes M, Evans RM, Venkataramanan R, Chatsudthipong V, Xie W.

Pharm Res. 2013 Sep;30(9):2199-208. doi: 10.1007/s11095-013-1101-9. Epub 2013 Jul 30.

4.

Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.

Karlgren M, Vildhede A, Norinder U, Wisniewski JR, Kimoto E, Lai Y, Haglund U, Artursson P.

J Med Chem. 2012 May 24;55(10):4740-63. doi: 10.1021/jm300212s. Epub 2012 May 15.

5.

Species-dependent uptake of glycylsarcosine but not oseltamivir in Pichia pastoris expressing the rat, mouse, and human intestinal peptide transporter PEPT1.

Hu Y, Chen X, Smith DE.

Drug Metab Dispos. 2012 Jul;40(7):1328-35. doi: 10.1124/dmd.111.044263. Epub 2012 Apr 9.

6.

Inhibition of the organic anion-transporting polypeptide 1B1 by quercetin: an in vitro and in vivo assessment.

Wu LX, Guo CX, Chen WQ, Yu J, Qu Q, Chen Y, Tan ZR, Wang G, Fan L, Li Q, Zhang W, Zhou HH.

Br J Clin Pharmacol. 2012 May;73(5):750-7. doi: 10.1111/j.1365-2125.2011.04150.x.

8.

Structural features determining the intestinal epithelial permeability and efflux of novel HIV-1 protease inhibitors.

Lazorova L, Hubatsch I, Ekegren JK, Gising J, Nakai D, Zaki NM, Bergström CA, Norinder U, Larhed M, Artursson P.

J Pharm Sci. 2011 Sep;100(9):3763-72. doi: 10.1002/jps.22570. Epub 2011 Apr 13.

9.

PKA regulates vacuolar H+-ATPase localization and activity via direct phosphorylation of the a subunit in kidney cells.

Alzamora R, Thali RF, Gong F, Smolak C, Li H, Baty CJ, Bertrand CA, Auchli Y, Brunisholz RA, Neumann D, Hallows KR, Pastor-Soler NM.

J Biol Chem. 2010 Aug 6;285(32):24676-85. doi: 10.1074/jbc.M110.106278. Epub 2010 Jun 4.

10.

Toxicology and drug delivery by cucurbit[n]uril type molecular containers.

Hettiarachchi G, Nguyen D, Wu J, Lucas D, Ma D, Isaacs L, Briken V.

PLoS One. 2010 May 6;5(5):e10514. doi: 10.1371/journal.pone.0010514.

11.

Cyanobacterial cyclopeptides as lead compounds to novel targeted cancer drugs.

Sainis I, Fokas D, Vareli K, Tzakos AG, Kounnis V, Briasoulis E.

Mar Drugs. 2010 Mar 15;8(3):629-57. doi: 10.3390/md8030629. Review.

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