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Results: 1 to 20 of 37

1.

Decoding F508del misfolding in cystic fibrosis.

Wang XR, Li C.

Biomolecules. 2014 May 6;4(2):498-509. doi: 10.3390/biom4020498.

PMID:
24970227
[PubMed - in process]
Free PMC Article
2.

The role of the cytosolic HSP70 chaperone system in diseases caused by misfolding and aberrant trafficking of ion channels.

Young JC.

Dis Model Mech. 2014 Mar;7(3):319-29. doi: 10.1242/dmm.014001.

PMID:
24609033
[PubMed - in process]
Free PMC Article
3.

Cystic fibrosis transmembrane conductance regulator chloride channel blockers: Pharmacological, biophysical and physiological relevance.

Linsdell P.

World J Biol Chem. 2014 Feb 26;5(1):26-39. doi: 10.4331/wjbc.v5.i1.26. Review.

PMID:
24600512
[PubMed]
Free PMC Article
4.

Genome-wide Membrane Protein Structure Prediction.

Piccoli S, Suku E, Garonzi M, Giorgetti A.

Curr Genomics. 2013 Aug;14(5):324-9. doi: 10.2174/13892029113149990009.

PMID:
24403851
[PubMed]
Free PMC Article
5.

Regulatory R region of the CFTR chloride channel is a dynamic integrator of phospho-dependent intra- and intermolecular interactions.

Bozoky Z, Krzeminski M, Muhandiram R, Birtley JR, Al-Zahrani A, Thomas PJ, Frizzell RA, Ford RC, Forman-Kay JD.

Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):E4427-36. doi: 10.1073/pnas.1315104110. Epub 2013 Nov 4.

PMID:
24191035
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Modeling the conformational changes underlying channel opening in CFTR.

Rahman KS, Cui G, Harvey SC, McCarty NA.

PLoS One. 2013 Sep 27;8(9):e74574. doi: 10.1371/journal.pone.0074574. eCollection 2013.

PMID:
24086355
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

ATP and AMP mutually influence their interaction with the ATP-binding cassette (ABC) adenylate kinase cystic fibrosis transmembrane conductance regulator (CFTR) at separate binding sites.

Randak CO, Dong Q, Ver Heul AR, Elcock AH, Welsh MJ.

J Biol Chem. 2013 Sep 20;288(38):27692-701. doi: 10.1074/jbc.M113.479675. Epub 2013 Aug 6.

PMID:
23921386
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Structural changes of CFTR R region upon phosphorylation: a plastic platform for intramolecular and intermolecular interactions.

Bozoky Z, Krzeminski M, Chong PA, Forman-Kay JD.

FEBS J. 2013 Sep;280(18):4407-16. doi: 10.1111/febs.12422. Epub 2013 Jul 25. Review.

PMID:
23826884
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Two salt bridges differentially contribute to the maintenance of cystic fibrosis transmembrane conductance regulator (CFTR) channel function.

Cui G, Freeman CS, Knotts T, Prince CZ, Kuang C, McCarty NA.

J Biol Chem. 2013 Jul 12;288(28):20758-67. doi: 10.1074/jbc.M113.476226. Epub 2013 May 24.

PMID:
23709221
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Converting nonhydrolyzable nucleotides to strong cystic fibrosis transmembrane conductance regulator (CFTR) agonists by gain of function (GOF) mutations.

Okeyo G, Wang W, Wei S, Kirk KL.

J Biol Chem. 2013 Jun 14;288(24):17122-33. doi: 10.1074/jbc.M112.442582. Epub 2013 Apr 25.

PMID:
23620589
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Cysteine scanning of CFTR's first transmembrane segment reveals its plausible roles in gating and permeation.

Gao X, Bai Y, Hwang TC.

Biophys J. 2013 Feb 19;104(4):786-97. doi: 10.1016/j.bpj.2012.12.048.

PMID:
23442957
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

CFTR inhibitors.

Verkman AS, Synder D, Tradtrantip L, Thiagarajah JR, Anderson MO.

Curr Pharm Des. 2013;19(19):3529-41. Review.

PMID:
23331030
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Correctors of ΔF508 CFTR restore global conformational maturation without thermally stabilizing the mutant protein.

He L, Kota P, Aleksandrov AA, Cui L, Jensen T, Dokholyan NV, Riordan JR.

FASEB J. 2013 Feb;27(2):536-45. doi: 10.1096/fj.12-216119. Epub 2012 Oct 26. Erratum in: FASEB J. 2014 Jun;28(6):2737.

PMID:
23104983
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Functional Rescue of F508del-CFTR Using Small Molecule Correctors.

Molinski S, Eckford PD, Pasyk S, Ahmadi S, Chin S, Bear CE.

Front Pharmacol. 2012 Sep 26;3:160. doi: 10.3389/fphar.2012.00160. eCollection 2012.

PMID:
23055971
[PubMed]
Free PMC Article
15.

Development of CFTR Structure.

Patrick AE, Thomas PJ.

Front Pharmacol. 2012 Sep 6;3:162. doi: 10.3389/fphar.2012.00162. eCollection 2012.

PMID:
22973227
[PubMed]
Free PMC Article
16.

Locating a plausible binding site for an open-channel blocker, GlyH-101, in the pore of the cystic fibrosis transmembrane conductance regulator.

Norimatsu Y, Ivetac A, Alexander C, O'Donnell N, Frye L, Sansom MS, Dawson DC.

Mol Pharmacol. 2012 Dec;82(6):1042-55. doi: 10.1124/mol.112.080267. Epub 2012 Aug 24.

PMID:
22923500
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Conformational changes relevant to channel activity and folding within the first nucleotide binding domain of the cystic fibrosis transmembrane conductance regulator.

Hudson RP, Chong PA, Protasevich II, Vernon R, Noy E, Bihler H, An JL, Kalid O, Sela-Culang I, Mense M, Senderowitz H, Brouillette CG, Forman-Kay JD.

J Biol Chem. 2012 Aug 17;287(34):28480-94. doi: 10.1074/jbc.M112.371138. Epub 2012 Jun 21.

PMID:
22722932
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

A chaperone trap contributes to the onset of cystic fibrosis.

Coppinger JA, Hutt DM, Razvi A, Koulov AV, Pankow S, Yates JR 3rd, Balch WE.

PLoS One. 2012;7(5):e37682. doi: 10.1371/journal.pone.0037682. Epub 2012 May 31.

PMID:
22701530
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

The human transporter associated with antigen processing: molecular models to describe peptide binding competent states.

Corradi V, Singh G, Tieleman DP.

J Biol Chem. 2012 Aug 10;287(33):28099-111. doi: 10.1074/jbc.M112.381251. Epub 2012 Jun 14.

PMID:
22700967
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Integrated analysis of residue coevolution and protein structure in ABC transporters.

Gulyás-Kovács A.

PLoS One. 2012;7(5):e36546. doi: 10.1371/journal.pone.0036546. Epub 2012 May 8.

PMID:
22590562
[PubMed - indexed for MEDLINE]
Free PMC Article

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