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Items: 1 to 20 of 99

1.

Enhancer Regulation of Transcriptional Bursting Parameters Revealed by Forced Chromatin Looping.

Bartman CR, Hsu SC, Hsiung CC, Raj A, Blobel GA.

Mol Cell. 2016 Apr 21;62(2):237-47. doi: 10.1016/j.molcel.2016.03.007. Epub 2016 Apr 7.

PMID:
27067601
2.

The therapeutic potential of genome editing for β-thalassemia.

Glaser A, McColl B, Vadolas J.

F1000Res. 2015 Dec 11;4. pii: F1000 Faculty Rev-1431. doi: 10.12688/f1000research.7087.1. eCollection 2015. Review.

3.

The expression of embryonic globin mRNA in a severely anemic mouse model induced by treatment with nitrogen-containing bisphosphonate.

Otsuka H, Takito J, Endo Y, Yagi H, Soeta S, Yanagisawa N, Nonaka N, Nakamura M.

BMC Hematol. 2016 Feb 11;16:4. doi: 10.1186/s12878-016-0041-0. eCollection 2016.

4.

Transcription factors LRF and BCL11A independently repress expression of fetal hemoglobin.

Masuda T, Wang X, Maeda M, Canver MC, Sher F, Funnell AP, Fisher C, Suciu M, Martyn GE, Norton LJ, Zhu C, Kurita R, Nakamura Y, Xu J, Higgs DR, Crossley M, Bauer DE, Orkin SH, Kharchenko PV, Maeda T.

Science. 2016 Jan 15;351(6270):285-9. doi: 10.1126/science.aad3312.

PMID:
26816381
5.

Dynamic Control of Enhancer Repertoires Drives Lineage and Stage-Specific Transcription during Hematopoiesis.

Huang J, Liu X, Li D, Shao Z, Cao H, Zhang Y, Trompouki E, Bowman TV, Zon LI, Yuan GC, Orkin SH, Xu J.

Dev Cell. 2016 Jan 11;36(1):9-23. doi: 10.1016/j.devcel.2015.12.014.

PMID:
26766440
6.

Genetic treatment of a molecular disorder: gene therapy approaches to sickle cell disease.

Hoban MD, Orkin SH, Bauer DE.

Blood. 2016 Feb 18;127(7):839-48. doi: 10.1182/blood-2015-09-618587. Epub 2016 Jan 12. Review.

PMID:
26758916
7.

Hemoglobin switching's surprise: the versatile transcription factor BCL11A is a master repressor of fetal hemoglobin.

Bauer DE, Orkin SH.

Curr Opin Genet Dev. 2015 Aug;33:62-70. doi: 10.1016/j.gde.2015.08.001. Epub 2015 Sep 14. Review.

PMID:
26375765
8.

BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis.

Canver MC, Smith EC, Sher F, Pinello L, Sanjana NE, Shalem O, Chen DD, Schupp PG, Vinjamur DS, Garcia SP, Luc S, Kurita R, Nakamura Y, Fujiwara Y, Maeda T, Yuan GC, Zhang F, Orkin SH, Bauer DE.

Nature. 2015 Nov 12;527(7577):192-7. doi: 10.1038/nature15521. Epub 2015 Sep 16.

PMID:
26375006
9.

Development and characterization of K562 cell clones expressing BCL11A-XL: Decreased hemoglobin production with fetal hemoglobin inducers and its rescue with mithramycin.

Finotti A, Gasparello J, Breveglieri G, Cosenza LC, Montagner G, Bresciani A, Altamura S, Bianchi N, Martini E, Gallerani E, Borgatti M, Gambari R.

Exp Hematol. 2015 Dec;43(12):1062-1071.e3. doi: 10.1016/j.exphem.2015.08.011. Epub 2015 Sep 3.

10.

A Quantitative Proteomic Analysis of Hemogenic Endothelium Reveals Differential Regulation of Hematopoiesis by SOX17.

Clarke RL, Robitaille AM, Moon RT, Keller G.

Stem Cell Reports. 2015 Aug 11;5(2):291-304. doi: 10.1016/j.stemcr.2015.07.008.

11.

2p15-p16.1 microdeletions encompassing and proximal to BCL11A are associated with elevated HbF in addition to neurologic impairment.

Funnell AP, Prontera P, Ottaviani V, Piccione M, Giambona A, Maggio A, Ciaffoni F, Stehling-Sun S, Marra M, Masiello F, Varricchio L, Stamatoyannopoulos JA, Migliaccio AR, Papayannopoulou T.

Blood. 2015 Jul 2;126(1):89-93. doi: 10.1182/blood-2015-04-638528. Epub 2015 May 27.

PMID:
26019277
12.

Pharmacological Induction of Human Fetal Globin Gene in Hydroxyurea-Resistant Primary Adult Erythroid Cells.

Chou YC, Chen RL, Lai ZS, Song JS, Chao YS, Shen CK.

Mol Cell Biol. 2015 Jul;35(14):2541-53. doi: 10.1128/MCB.00035-15. Epub 2015 May 18.

13.

BCL11A deletions result in fetal hemoglobin persistence and neurodevelopmental alterations.

Basak A, Hancarova M, Ulirsch JC, Balci TB, Trkova M, Pelisek M, Vlckova M, Muzikova K, Cermak J, Trka J, Dyment DA, Orkin SH, Daly MJ, Sedlacek Z, Sankaran VG.

J Clin Invest. 2015 Jun;125(6):2363-8. doi: 10.1172/JCI81163. Epub 2015 May 4.

14.

Distinctive patterns of evolution of the δ-globin gene (HBD) in primates.

Moleirinho A, Lopes AM, Seixas S, Morales-Hojas R, Prata MJ, Amorim A.

PLoS One. 2015 Apr 8;10(4):e0123365. doi: 10.1371/journal.pone.0123365. eCollection 2015.

15.

2014 William Allan Award: A hematologist's pursuit of hemoglobin genetics.

Orkin SH.

Am J Hum Genet. 2015 Mar 5;96(3):354-60. doi: 10.1016/j.ajhg.2014.12.007. No abstract available.

16.

Anemia: progress in molecular mechanisms and therapies.

Sankaran VG, Weiss MJ.

Nat Med. 2015 Mar;21(3):221-30. doi: 10.1038/nm.3814. Review.

17.

Comparison of DNA methylation profiles in human fetal and adult red blood cell progenitors.

Lessard S, Beaudoin M, Benkirane K, Lettre G.

Genome Med. 2015 Jan 20;7(1):1. doi: 10.1186/s13073-014-0122-2. eCollection 2015.

18.

Altered chromatin occupancy of master regulators underlies evolutionary divergence in the transcriptional landscape of erythroid differentiation.

Ulirsch JC, Lacy JN, An X, Mohandas N, Mikkelsen TS, Sankaran VG.

PLoS Genet. 2014 Dec 18;10(12):e1004890. doi: 10.1371/journal.pgen.1004890. eCollection 2014 Dec.

19.

Using mouse models to study function of transcriptional factors in T cell development.

Li P, Xiao Y, Liu Z, Liu P.

Cell Regen (Lond). 2012 Oct 10;1(1):8. doi: 10.1186/2045-9769-1-8. eCollection 2012. Review.

20.

An integrated cell purification and genomics strategy reveals multiple regulators of pancreas development.

Benitez CM, Qu K, Sugiyama T, Pauerstein PT, Liu Y, Tsai J, Gu X, Ghodasara A, Arda HE, Zhang J, Dekker JD, Tucker HO, Chang HY, Kim SK.

PLoS Genet. 2014 Oct 16;10(10):e1004645. doi: 10.1371/journal.pgen.1004645. eCollection 2014 Oct.

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