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SREBP1c-CRY1 signalling represses hepatic glucose production by promoting FOXO1 degradation during refeeding.

Jang H, Lee GY, Selby CP, Lee G, Jeon YG, Lee JH, Cheng KK, Titchenell P, Birnbaum MJ, Xu A, Sancar A, Kim JB.

Nat Commun. 2016 Jul 14;7:12180. doi: 10.1038/ncomms12180.


Systems-wide Experimental and Modeling Analysis of Insulin Signaling through Forkhead Box Protein O1 (FOXO1) in Human Adipocytes, Normally and in Type 2 Diabetes.

Rajan MR, Nyman E, Kjølhede P, Cedersund G, Strålfors P.

J Biol Chem. 2016 Jul 22;291(30):15806-19. doi: 10.1074/jbc.M116.715763. Epub 2016 May 20.


The C. elegans Ortholog of USP7 controls DAF-16 stability in Insulin/IGF-1-like signaling.

Heimbucher T, Hunter T.

Worm. 2015 Nov 17;4(4):e1103429. doi: 10.1080/21624054.2015.1103429. eCollection 2015 Oct-Dec.


Negative regulation of the FOXO3a transcription factor by mTORC2 induces a pro-survival response following exposure to ultraviolet-B irradiation.

Feehan RP, Shantz LM.

Cell Signal. 2016 Aug;28(8):798-809. doi: 10.1016/j.cellsig.2016.03.013. Epub 2016 Apr 4.


Ubiquitin-specific Peptidase 10 (USP10) Deubiquitinates and Stabilizes MutS Homolog 2 (MSH2) to Regulate Cellular Sensitivity to DNA Damage.

Zhang M, Hu C, Tong D, Xiang S, Williams K, Bai W, Li GM, Bepler G, Zhang X.

J Biol Chem. 2016 May 13;291(20):10783-91. doi: 10.1074/jbc.M115.700047. Epub 2016 Mar 14.


Murine Double-Minute 2 Homolog Single Nucleotide Polymorphisms 285 and 309 in Cervical Carcinogenesis.

Roszak A, Misztal M, Sowińska A, Jagodziński PP.

Mol Diagn Ther. 2015 Aug;19(4):235-44. doi: 10.1007/s40291-015-0153-4.


Robust concentration and frequency control in oscillatory homeostats.

Thorsen K, Agafonov O, Selstø CH, Jolma IW, Ni XY, Drengstig T, Ruoff P.

PLoS One. 2014 Sep 19;9(9):e107766. doi: 10.1371/journal.pone.0107766. eCollection 2014.


FoxO3a and disease progression.

Nho RS, Hergert P.

World J Biol Chem. 2014 Aug 26;5(3):346-54. doi: 10.4331/wjbc.v5.i3.346. Review.


Stress-induced alternative splice forms of MDM2 and MDMX modulate the p53-pathway in distinct ways.

Jacob AG, Singh RK, Comiskey DF Jr, Rouhier MF, Mohammad F, Bebee TW, Chandler DS.

PLoS One. 2014 Aug 8;9(8):e104444. doi: 10.1371/journal.pone.0104444. eCollection 2014.


Identification of a new class of MDM2 inhibitor that inhibits growth of orthotopic pancreatic tumors in mice.

Wang W, Qin JJ, Voruganti S, Wang MH, Sharma H, Patil S, Zhou J, Wang H, Mukhopadhyay D, Buolamwini JK, Zhang R.

Gastroenterology. 2014 Oct;147(4):893-902.e2. doi: 10.1053/j.gastro.2014.07.001. Epub 2014 Jul 10.


AMPK reverses the mesenchymal phenotype of cancer cells by targeting the Akt-MDM2-Foxo3a signaling axis.

Chou CC, Lee KH, Lai IL, Wang D, Mo X, Kulp SK, Shapiro CL, Chen CS.

Cancer Res. 2014 Sep 1;74(17):4783-95. doi: 10.1158/0008-5472.CAN-14-0135. Epub 2014 Jul 3.


FoxO3a nuclear localization and its association with β-catenin and Smads in IFN-α-treated hepatocellular carcinoma cell lines.

Ceballos MP, Parody JP, Quiroga AD, Casella ML, Francés DE, Larocca MC, Carnovale CE, Alvarez Mde L, Carrillo MC.

J Interferon Cytokine Res. 2014 Nov;34(11):858-69. doi: 10.1089/jir.2013.0124. Epub 2014 Jun 20.


CCM1 and the second life of proteins in adhesion complexes.

van den Berg MC, Burgering BM.

Cell Adh Migr. 2014;8(2):146-57. Review.


Bcl2 deficiency activates FoxO through Akt inactivation and accelerates osteoblast differentiation.

Moriishi T, Kawai Y, Komori H, Rokutanda S, Eguchi Y, Tsujimoto Y, Asahina I, Komori T.

PLoS One. 2014 Jan 20;9(1):e86629. doi: 10.1371/journal.pone.0086629. eCollection 2014.


The regulation of MDM2 oncogene and its impact on human cancers.

Zhao Y, Yu H, Hu W.

Acta Biochim Biophys Sin (Shanghai). 2014 Mar;46(3):180-9. doi: 10.1093/abbs/gmt147. Epub 2014 Jan 3. Review.


Novel perspective: exercise training stimulus triggers the expression of the oncoprotein human double minute-2 in human skeletal muscle.

Roudier E, Aiken J, Slopack D, Gouzi F, Mercier J, Haas TL, Gustafsson T, Hayot M, Birot O.

Physiol Rep. 2013 Jul;1(2):e00028. doi: 10.1002/phy2.28. Epub 2013 Jul 15.


The MDM2-p53 pathway revisited.

Nag S, Qin J, Srivenugopal KS, Wang M, Zhang R.

J Biomed Res. 2013 Jul;27(4):254-71. doi: 10.7555/JBR.27.20130030. Epub 2013 Jun 6.


High cytoplasmic FOXO1 and pFOXO1 expression in astrocytomas are associated with worse surgical outcome.

Chen C, Xu T, Zhou J, Yan Y, Li W, Yu H, Hu G, Ding X, Chen J, Lu Y.

PLoS One. 2013 Jul 9;8(7):e69260. doi: 10.1371/journal.pone.0069260. Print 2013.


Computational modelling of the regulation of Insulin signalling by oxidative stress.

Smith GR, Shanley DP.

BMC Syst Biol. 2013 May 24;7:41. doi: 10.1186/1752-0509-7-41.

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