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Items: 15

1.

Recombinant pre-miR-29b for Alzheimer´s disease therapeutics.

Pereira PA, Tomás JF, Queiroz JA, Figueiras AR, Sousa F.

Sci Rep. 2016 Jan 28;6:19946. doi: 10.1038/srep19946.

2.

Conformational Dynamics and Binding Free Energies of Inhibitors of BACE-1: From the Perspective of Protonation Equilibria.

Kim MO, Blachly PG, McCammon JA.

PLoS Comput Biol. 2015 Oct 27;11(10):e1004341. doi: 10.1371/journal.pcbi.1004341. eCollection 2015 Oct.

3.

Design and Synthesis of Novel Arylketo-containing P1-P3 Linked Macro-cyclic BACE-1 Inhibitors.

Sandgren V, Belda O, Kvarnström I, Lindberg J, Samuelsson B, Dahlgren A.

Open Med Chem J. 2015 Mar 31;9:13-26. doi: 10.2174/1874104501509010013. eCollection 2015.

4.

Application of computational methods for the design of BACE-1 inhibitors: validation of in silico modelling.

Bajda M, Jończyk J, Malawska B, Filipek S.

Int J Mol Sci. 2014 Mar 24;15(3):5128-39. doi: 10.3390/ijms15035128.

5.

A peptide binding to the β-site of APP improves spatial memory and attenuates Aβ burden in Alzheimer's disease transgenic mice.

Yang SG, Wang SW, Zhao M, Zhang R, Zhou WW, Li YN, Su YJ, Zhang H, Yu XL, Liu RT.

PLoS One. 2012;7(11):e48540. doi: 10.1371/journal.pone.0048540. Epub 2012 Nov 1.

6.

Adaptor protein 2-mediated endocytosis of the β-secretase BACE1 is dispensable for amyloid precursor protein processing.

Prabhu Y, Burgos PV, Schindler C, Farías GG, Magadán JG, Bonifacino JS.

Mol Biol Cell. 2012 Jun;23(12):2339-51. doi: 10.1091/mbc.E11-11-0944. Epub 2012 May 2. Erratum in: Mol Biol Cell. 2012 Jul;23(13):2620.

7.

Protease regulation: the Yin and Yang of neural development and disease.

Bai G, Pfaff SL.

Neuron. 2011 Oct 6;72(1):9-21. doi: 10.1016/j.neuron.2011.09.012. Review.

8.

Docosahexaenoic acid reduces amyloid beta production via multiple pleiotropic mechanisms.

Grimm MO, Kuchenbecker J, Grösgen S, Burg VK, Hundsdörfer B, Rothhaar TL, Friess P, de Wilde MC, Broersen LM, Penke B, Péter M, Vígh L, Grimm HS, Hartmann T.

J Biol Chem. 2011 Apr 22;286(16):14028-39. doi: 10.1074/jbc.M110.182329. Epub 2011 Feb 15.

9.

Viable mouse gene ablations that robustly alter brain Aβ levels are rare.

Toyn JH, Lin XA, Thompson MW, Guss V, Meredith JE Jr, Sankaranarayanan S, Barrezueta N, Corradi J, Majumdar A, Small DL, Hansard M, Lanthorn T, Westphal RS, Albright CF.

BMC Neurosci. 2010 Nov 5;11:143. doi: 10.1186/1471-2202-11-143.

10.

The transcriptionally active amyloid precursor protein (APP) intracellular domain is preferentially produced from the 695 isoform of APP in a {beta}-secretase-dependent pathway.

Belyaev ND, Kellett KA, Beckett C, Makova NZ, Revett TJ, Nalivaeva NN, Hooper NM, Turner AJ.

J Biol Chem. 2010 Dec 31;285(53):41443-54. doi: 10.1074/jbc.M110.141390. Epub 2010 Oct 20.

11.
12.

Quantitative assessment of the expanding complementarity between public and commercial databases of bioactive compounds.

Southan C, Várkonyi P, Muresan S.

J Cheminform. 2009 Jul 6;1(1):10. doi: 10.1186/1758-2946-1-10.

13.

An overview of APP processing enzymes and products.

Chow VW, Mattson MP, Wong PC, Gleichmann M.

Neuromolecular Med. 2010 Mar;12(1):1-12. doi: 10.1007/s12017-009-8104-z. Review.

14.

MicroRNA implications across neurodevelopment and neuropathology.

Martino S, di Girolamo I, Orlacchio A, Datti A, Orlacchio A.

J Biomed Biotechnol. 2009;2009:654346. doi: 10.1155/2009/654346. Epub 2009 Oct 13. Review.

15.

Klotho is a substrate for alpha-, beta- and gamma-secretase.

Bloch L, Sineshchekova O, Reichenbach D, Reiss K, Saftig P, Kuro-o M, Kaether C.

FEBS Lett. 2009 Oct 6;583(19):3221-4. doi: 10.1016/j.febslet.2009.09.009. Epub 2009 Sep 6.

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