Display Settings:

Format
Items per page
Sort by

Send to:

Choose Destination

Results: 17

1.

Transition-state inhibitors of purine salvage and other prospective enzyme targets in malaria.

Ducati RG, Namanja-Magliano HA, Schramm VL.

Future Med Chem. 2013 Jul;5(11):1341-60. doi: 10.4155/fmc.13.51. Review.

PMID:
23859211
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Recycling nicotinamide. The transition-state structure of human nicotinamide phosphoribosyltransferase.

Burgos ES, Vetticatt MJ, Schramm VL.

J Am Chem Soc. 2013 Mar 6;135(9):3485-93. doi: 10.1021/ja310180c. Epub 2013 Feb 19.

PMID:
23373462
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Acyclic immucillin phosphonates: second-generation inhibitors of Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase.

Hazleton KZ, Ho MC, Cassera MB, Clinch K, Crump DR, Rosario I Jr, Merino EF, Almo SC, Tyler PC, Schramm VL.

Chem Biol. 2012 Jun 22;19(6):721-30. doi: 10.1016/j.chembiol.2012.04.012.

PMID:
22726686
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Loop residues and catalysis in OMP synthase.

Wang GP, Hansen MR, Grubmeyer C.

Biochemistry. 2012 Jun 5;51(22):4406-15. Epub 2012 May 23.

PMID:
22531099
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Structure of Salmonella typhimurium OMP synthase in a complete substrate complex.

Grubmeyer C, Hansen MR, Fedorov AA, Almo SC.

Biochemistry. 2012 Jun 5;51(22):4397-405. Epub 2012 May 23.

PMID:
22531064
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Triple isotopic labeling and kinetic isotope effects: exposing H-transfer steps in enzymatic systems.

Sen A, Yahashiri A, Kohen A.

Biochemistry. 2011 Jul 26;50(29):6462-8. doi: 10.1021/bi2003873. Epub 2011 Jun 30.

PMID:
21688781
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Purine and pyrimidine pathways as targets in Plasmodium falciparum.

Cassera MB, Zhang Y, Hazleton KZ, Schramm VL.

Curr Top Med Chem. 2011;11(16):2103-15. Review.

PMID:
21619511
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Transition-state analysis of Trypanosoma cruzi uridine phosphorylase-catalyzed arsenolysis of uridine.

Silva RG, Vetticatt MJ, Merino EF, Cassera MB, Schramm VL.

J Am Chem Soc. 2011 Jun 29;133(25):9923-31. doi: 10.1021/ja2031294. Epub 2011 Jun 3.

PMID:
21599004
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Ground-state destabilization in orotate phosphoribosyltransferases by binding isotope effects.

Zhang Y, Schramm VL.

Biochemistry. 2011 May 31;50(21):4813-8. doi: 10.1021/bi200638x. Epub 2011 May 6.

PMID:
21526795
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Leaving group activation and pyrophosphate ionic state at the catalytic site of Plasmodium falciparum orotate phosphoribosyltransferase.

Zhang Y, Deng H, Schramm VL.

J Am Chem Soc. 2010 Dec 1;132(47):17023-31. doi: 10.1021/ja107806j. Epub 2010 Nov 10.

PMID:
21067187
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Kinetic isotope effects in asymmetric reactions.

Giagou T, Meyer MP.

Chemistry. 2010 Sep 17;16(35):10616-28. doi: 10.1002/chem.201001018.

PMID:
20669194
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Pyrophosphate interactions at the transition states of Plasmodium falciparum and human orotate phosphoribosyltransferases.

Zhang Y, Schramm VL.

J Am Chem Soc. 2010 Jun 30;132(25):8787-94. doi: 10.1021/ja102849w.

PMID:
20527751
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Electrophilic aromatic selenylation: new OPRT inhibitors.

Abdo M, Zhang Y, Schramm VL, Knapp S.

Org Lett. 2010 Jul 2;12(13):2982-5. doi: 10.1021/ol1010032.

PMID:
20521773
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Plasmodium dihydroorotate dehydrogenase: a promising target for novel anti-malarial chemotherapy.

Phillips MA, Rathod PK.

Infect Disord Drug Targets. 2010 Jun;10(3):226-39. Review.

PMID:
20334617
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Pyrophosphate activation in hypoxanthine--guanine phosphoribosyltransferase with transition state analogue.

Deng H, Callender R, Schramm VL, Grubmeyer C.

Biochemistry. 2010 Mar 30;49(12):2705-14. doi: 10.1021/bi100012u.

PMID:
20170081
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Through-Space Effects of Substituents Dominate Molecular Electrostatic Potentials of Substituted Arenes.

Wheeler SE, Houk KN.

J Chem Theory Comput. 2009 Sep 8;5(9):2301-2312.

PMID:
20161573
[PubMed]
Free PMC Article
17.

Transition States.

Schramm VL.

J Biol Chem. 2009 Nov 20;284(47):32201-8. doi: 10.1074/jbc.X109.060111. Epub 2009 Sep 16. No abstract available.

PMID:
19758992
[PubMed - indexed for MEDLINE]
Free PMC Article

Display Settings:

Format
Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

Write to the Help Desk