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Results: 1 to 20 of 28

Cited In for PubMed (Select 19254759)


High-Dose Intravenous Vitamin C Combined with Cytotoxic Chemotherapy in Patients with Advanced Cancer: A Phase I-II Clinical Trial.

Hoffer LJ, Robitaille L, Zakarian R, Melnychuk D, Kavan P, Agulnik J, Cohen V, Small D, Miller WH Jr.

PLoS One. 2015 Apr 7;10(4):e0120228. doi: 10.1371/journal.pone.0120228. eCollection 2015.


Ascorbate as a co-factor for fe- and 2-oxoglutarate dependent dioxygenases: physiological activity in tumor growth and progression.

Kuiper C, Vissers MC.

Front Oncol. 2014 Dec 10;4:359. doi: 10.3389/fonc.2014.00359. eCollection 2014. Review.


Current limitations of murine models in oncology for ascorbate research.

Campbell EJ, Dachs GU.

Front Oncol. 2014 Oct 14;4:282. doi: 10.3389/fonc.2014.00282. eCollection 2014. Review.


Increasing Superoxide Production and the Labile Iron Pool in Tumor Cells may Sensitize Them to Extracellular Ascorbate.

McCarty MF, Contreras F.

Front Oncol. 2014 Sep 16;4:249. doi: 10.3389/fonc.2014.00249. eCollection 2014. Review.


Epigenetic impacts of ascorbate on human metastatic melanoma cells.

Venturelli S, Sinnberg TW, Berger A, Noor S, Levesque MP, Böcker A, Niessner H, Lauer UM, Bitzer M, Garbe C, Busch C.

Front Oncol. 2014 Aug 25;4:227. doi: 10.3389/fonc.2014.00227. eCollection 2014.


Schedule Dependence in Cancer Therapy: Intravenous Vitamin C and the Systemic Saturation Hypothesis.

Gonzalez MJ, Miranda Massari JR, Duconge J, Riordan NH, Ichim T.

J Orthomol Med. 2012 Jan 1;27(1):9-12.


Increased Tumor Ascorbate is Associated with Extended Disease-Free Survival and Decreased Hypoxia-Inducible Factor-1 Activation in Human Colorectal Cancer.

Kuiper C, Dachs GU, Munn D, Currie MJ, Robinson BA, Pearson JF, Vissers MC.

Front Oncol. 2014 Feb 4;4:10. doi: 10.3389/fonc.2014.00010. eCollection 2014.


Intravenous ascorbate improves spatial memory in middle-aged APP/PSEN1 and wild type mice.

Kennard JA, Harrison FE.

Behav Brain Res. 2014 May 1;264:34-42. doi: 10.1016/j.bbr.2014.01.044. Epub 2014 Feb 5.


The hypoxia-inducible factor renders cancer cells more sensitive to vitamin C-induced toxicity.

Tian W, Wang Y, Xu Y, Guo X, Wang B, Sun L, Liu L, Cui F, Zhuang Q, Bao X, Schley G, Chung TL, Laslett AL, Willam C, Qin B, Maxwell PH, Esteban MA.

J Biol Chem. 2014 Feb 7;289(6):3339-51. doi: 10.1074/jbc.M113.538157. Epub 2013 Dec 26.


The ROS-induced cytotoxicity of ascorbate is attenuated by hypoxia and HIF-1alpha in the NCI60 cancer cell lines.

Sinnberg T, Noor S, Venturelli S, Berger A, Schuler P, Garbe C, Busch C.

J Cell Mol Med. 2014 Mar;18(3):530-41. doi: 10.1111/jcmm.12207. Epub 2013 Dec 14.


Ascorbic acid and a cytostatic inhibitor of glycolysis synergistically induce apoptosis in non-small cell lung cancer cells.

Vuyyuri SB, Rinkinen J, Worden E, Shim H, Lee S, Davis KR.

PLoS One. 2013 Jun 11;8(6):e67081. doi: 10.1371/journal.pone.0067081. Print 2013.


Phase I clinical trial to evaluate the safety, tolerability, and pharmacokinetics of high-dose intravenous ascorbic acid in patients with advanced cancer.

Stephenson CM, Levin RD, Spector T, Lis CG.

Cancer Chemother Pharmacol. 2013 Jul;72(1):139-46. doi: 10.1007/s00280-013-2179-9. Epub 2013 May 14.


Parenteral ascorbate as a cancer therapeutic: a reassessment based on pharmacokinetics.

Parrow NL, Leshin JA, Levine M.

Antioxid Redox Signal. 2013 Dec 10;19(17):2141-56. doi: 10.1089/ars.2013.5372. Epub 2013 Jun 19. Review.


Preclinical demonstration of synergistic Active Nutrients/Drug (AND) combination as a potential treatment for malignant pleural mesothelioma.

Volta V, Ranzato E, Martinotti S, Gallo S, Russo MV, Mutti L, Biffo S, Burlando B.

PLoS One. 2013;8(3):e58051. doi: 10.1371/journal.pone.0058051. Epub 2013 Mar 6.


Ascorbic acid kills Epstein-Barr virus positive Burkitt lymphoma cells and Epstein-Barr virus transformed B-cells in vitro, but not in vivo.

Shatzer AN, Espey MG, Chavez M, Tu H, Levine M, Cohen JI.

Leuk Lymphoma. 2013 May;54(5):1069-78. doi: 10.3109/10428194.2012.739686. Epub 2012 Nov 15.


Ascorbic acid: chemistry, biology and the treatment of cancer.

Du J, Cullen JJ, Buettner GR.

Biochim Biophys Acta. 2012 Dec;1826(2):443-57. doi: 10.1016/j.bbcan.2012.06.003. Epub 2012 Jun 20. Review.


Epigallocatechin-3-gallate induces mesothelioma cell death via H2 O2 -dependent T-type Ca2+ channel opening.

Ranzato E, Martinotti S, Magnelli V, Murer B, Biffo S, Mutti L, Burlando B.

J Cell Mol Med. 2012 Nov;16(11):2667-78. doi: 10.1111/j.1582-4934.2012.01584.x.


Vitamin C: a concentration-function approach yields pharmacology and therapeutic discoveries.

Levine M, Padayatty SJ, Espey MG.

Adv Nutr. 2011 Mar;2(2):78-88. doi: 10.3945/an.110.000109. Epub 2011 Mar 10. Review.


Pharmacologic doses of ascorbic acid repress specificity protein (Sp) transcription factors and Sp-regulated genes in colon cancer cells.

Pathi SS, Lei P, Sreevalsan S, Chadalapaka G, Jutooru I, Safe S.

Nutr Cancer. 2011;63(7):1133-42. doi: 10.1080/01635581.2011.605984. Epub 2011 Sep 15.

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