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Preventing Damage Limitation: Targeting DNA-PKcs and DNA Double-Strand Break Repair Pathways for Ovarian Cancer Therapy.

Dungl DA, Maginn EN, Stronach EA.

Front Oncol. 2015 Oct 26;5:240. doi: 10.3389/fonc.2015.00240. eCollection 2015. Review.


The Catalytic Subunit of DNA-Dependent Protein Kinase Coordinates with Polo-Like Kinase 1 to Facilitate Mitotic Entry.

Lee KJ, Shang ZF, Lin YF, Sun J, Morotomi-Yano K, Saha D, Chen BP.

Neoplasia. 2015 Apr;17(4):329-38. doi: 10.1016/j.neo.2015.02.004.


The DNA-dependent protein kinase: A multifunctional protein kinase with roles in DNA double strand break repair and mitosis.

Jette N, Lees-Miller SP.

Prog Biophys Mol Biol. 2015 Mar;117(2-3):194-205. doi: 10.1016/j.pbiomolbio.2014.12.003. Epub 2014 Dec 27. Review.


Beyond DNA repair: DNA-PK function in cancer.

Goodwin JF, Knudsen KE.

Cancer Discov. 2014 Oct;4(10):1126-39. doi: 10.1158/2159-8290.CD-14-0358. Epub 2014 Aug 28. Review.


Polo-like kinase 1 (PLK1) and protein phosphatase 6 (PP6) regulate DNA-dependent protein kinase catalytic subunit (DNA-PKcs) phosphorylation in mitosis.

Douglas P, Ye R, Trinkle-Mulcahy L, Neal JA, De Wever V, Morrice NA, Meek K, Lees-Miller SP.

Biosci Rep. 2014 Jun 25;34(3). pii: e00113. doi: 10.1042/BSR20140051.


Phosphorylation of the cryptochrome 1 C-terminal tail regulates circadian period length.

Gao P, Yoo SH, Lee KJ, Rosensweig C, Takahashi JS, Chen BP, Green CB.

J Biol Chem. 2013 Dec 6;288(49):35277-86. doi: 10.1074/jbc.M113.509604. Epub 2013 Oct 24.


Valosin-containing protein regulates the proteasome-mediated degradation of DNA-PKcs in glioma cells.

Jiang N, Shen Y, Fei X, Sheng K, Sun P, Qiu Y, Larner J, Cao L, Kong X, Mi J.

Cell Death Dis. 2013 May 30;4:e647. doi: 10.1038/cddis.2013.171.


Stathmin regulates mutant p53 stability and transcriptional activity in ovarian cancer.

Sonego M, Schiappacassi M, Lovisa S, Dall'Acqua A, Bagnoli M, Lovat F, Libra M, D'Andrea S, Canzonieri V, Militello L, Napoli M, Giorda G, Pivetta B, Mezzanzanica D, Barbareschi M, Valeri B, Canevari S, Colombatti A, Belletti B, Del Sal G, Baldassarre G.

EMBO Mol Med. 2013 May;5(5):707-22. doi: 10.1002/emmm.201201504. Epub 2013 Apr 22. Erratum in: EMBO Mol Med. 2014 Feb;6(2):295.


Detection and repair of ionizing radiation-induced DNA double strand breaks: new developments in nonhomologous end joining.

Wang C, Lees-Miller SP.

Int J Radiat Oncol Biol Phys. 2013 Jul 1;86(3):440-9. doi: 10.1016/j.ijrobp.2013.01.011. Epub 2013 Feb 20. Review.


Response to DNA damage: why do we need to focus on protein phosphatases?

Shimada M, Nakanishi M.

Front Oncol. 2013 Jan 31;3:8. doi: 10.3389/fonc.2013.00008. eCollection 2013.


Phosphoproteomic analysis reveals that PP4 dephosphorylates KAP-1 impacting the DNA damage response.

Lee DH, Goodarzi AA, Adelmant GO, Pan Y, Jeggo PA, Marto JA, Chowdhury D.

EMBO J. 2012 May 16;31(10):2403-15. doi: 10.1038/emboj.2012.86. Epub 2012 Apr 10.


PP6 regulatory subunit R1 is bidentate anchor for targeting protein phosphatase-6 to DNA-dependent protein kinase.

Hosing AS, Valerie NC, Dziegielewski J, Brautigan DL, Larner JM.

J Biol Chem. 2012 Mar 16;287(12):9230-9. doi: 10.1074/jbc.M111.333708. Epub 2012 Feb 1.


Induction of DNA damage by deguelin is mediated through reducing DNA repair genes in human non-small cell lung cancer NCI-H460 cells.

Ji BC, Yu CC, Yang ST, Hsia TC, Yang JS, Lai KC, Ko YC, Lin JJ, Lai TY, Chung JG.

Oncol Rep. 2012 Apr;27(4):959-64. doi: 10.3892/or.2012.1622. Epub 2012 Jan 4.


Serine/threonine protein phosphatase 6 modulates the radiation sensitivity of glioblastoma.

Shen Y, Wang Y, Sheng K, Fei X, Guo Q, Larner J, Kong X, Qiu Y, Mi J.

Cell Death Dis. 2011 Dec 8;2:e241. doi: 10.1038/cddis.2011.126.


What goes on must come off: phosphatases gate-crash the DNA damage response.

Lee DH, Chowdhury D.

Trends Biochem Sci. 2011 Nov;36(11):569-77. doi: 10.1016/j.tibs.2011.08.007. Epub 2011 Sep 18. Review.


Protein phosphatase PP6 is required for homology-directed repair of DNA double-strand breaks.

Zhong J, Liao J, Liu X, Wang P, Liu J, Hou W, Zhu B, Yao L, Wang J, Li J, Stark JM, Xie Y, Xu X.

Cell Cycle. 2011 May 1;10(9):1411-9. Epub 2011 May 1.


Protein phosphatase 6 regulates mitotic spindle formation by controlling the T-loop phosphorylation state of Aurora A bound to its activator TPX2.

Zeng K, Bastos RN, Barr FA, Gruneberg U.

J Cell Biol. 2010 Dec 27;191(7):1315-32. doi: 10.1083/jcb.201008106.


Phosphatases in the cellular response to DNA damage.

Freeman AK, Monteiro AN.

Cell Commun Signal. 2010 Sep 22;8:27. doi: 10.1186/1478-811X-8-27.


Pro-tumorigenic effects of miR-31 loss in mesothelioma.

Ivanov SV, Goparaju CM, Lopez P, Zavadil J, Toren-Haritan G, Rosenwald S, Hoshen M, Chajut A, Cohen D, Pass HI.

J Biol Chem. 2010 Jul 23;285(30):22809-17. doi: 10.1074/jbc.M110.100354. Epub 2010 May 12.


Protein phosphatase 6 interacts with the DNA-dependent protein kinase catalytic subunit and dephosphorylates gamma-H2AX.

Douglas P, Zhong J, Ye R, Moorhead GB, Xu X, Lees-Miller SP.

Mol Cell Biol. 2010 Mar;30(6):1368-81. doi: 10.1128/MCB.00741-09. Epub 2010 Jan 11.

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