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Items: 1 to 20 of 37


DMXL2 drives epithelial to mesenchymal transition in hormonal therapy resistant breast cancer through Notch hyper-activation.

Faronato M, Nguyen VT, Patten DK, Lombardo Y, Steel JH, Patel N, Woodley L, Shousha S, Pruneri G, Coombes RC, Magnani L.

Oncotarget. 2015 Sep 8;6(26):22467-79.


A novel lung explant model for the ex vivo study of efficacy and mechanisms of anti-influenza drugs.

Nicholas B, Staples KJ, Moese S, Meldrum E, Ward J, Dennison P, Havelock T, Hinks TS, Amer K, Woo E, Chamberlain M, Singh N, North M, Pink S, Wilkinson TM, Djukanović R.

J Immunol. 2015 Jun 15;194(12):6144-54. doi: 10.4049/jimmunol.1402283. Epub 2015 May 1.


Discovery of a Small-Molecule Probe for V-ATPase Function.

Aldrich LN, Kuo SY, Castoreno AB, Goel G, Kuballa P, Rees MG, Seashore-Ludlow BA, Cheah JH, Latorre IJ, Schreiber SL, Shamji AF, Xavier RJ.

J Am Chem Soc. 2015 Apr 29;137(16):5563-8. doi: 10.1021/jacs.5b02150. Epub 2015 Apr 20.


Vacuolin-1 potently and reversibly inhibits autophagosome-lysosome fusion by activating RAB5A.

Lu Y, Dong S, Hao B, Li C, Zhu K, Guo W, Wang Q, Cheung KH, Wong CW, Wu WT, Markus H, Yue J.

Autophagy. 2014;10(11):1895-905. doi: 10.4161/auto.32200. Epub 2014 Oct 30.


Mutations in the proteolipid subunits of the vacuolar H+-ATPase provide resistance to indolotryptoline natural products.

Chang FY, Kawashima SA, Brady SF.

Biochemistry. 2014 Nov 18;53(45):7123-31. doi: 10.1021/bi501078j. Epub 2014 Oct 31.


Intracellular trafficking of AIP56, an NF-κB-cleaving toxin from Photobacterium damselae subsp. piscicida.

Pereira LM, Pinto RD, Silva DS, Moreira AR, Beitzinger C, Oliveira P, Sampaio P, Benz R, Azevedo JE, dos Santos NM, do Vale A.

Infect Immun. 2014 Dec;82(12):5270-85. doi: 10.1128/IAI.02623-14. Epub 2014 Oct 6.


PA1b inhibitor binding to subunits c and e of the vacuolar ATPase reveals its insecticidal mechanism.

Muench SP, Rawson S, Eyraud V, Delmas AF, Da Silva P, Phillips C, Trinick J, Harrison MA, Gressent F, Huss M.

J Biol Chem. 2014 Jun 6;289(23):16399-408. doi: 10.1074/jbc.M113.541250. Epub 2014 May 2.


Attenuation of Candida albicans virulence with focus on disruption of its vacuole functions.

Olsen I.

J Oral Microbiol. 2014 Apr 1;6. doi: 10.3402/jom.v6.23898. eCollection 2014. Review.


A functional screen for copper homeostasis genes identifies a pharmacologically tractable cellular system.

Schlecht U, Suresh S, Xu W, Aparicio AM, Chu A, Proctor MJ, Davis RW, Scharfe C, St Onge RP.

BMC Genomics. 2014 Apr 5;15:263. doi: 10.1186/1471-2164-15-263.


Advances in targeting the vacuolar proton-translocating ATPase (V-ATPase) for anti-fungal therapy.

Hayek SR, Lee SA, Parra KJ.

Front Pharmacol. 2014 Jan 27;5:4. doi: 10.3389/fphar.2014.00004. eCollection 2014. Review.


Machine learning estimates of natural product conformational energies.

Rupp M, Bauer MR, Wilcken R, Lange A, Reutlinger M, Boeckler FM, Schneider G.

PLoS Comput Biol. 2014 Jan;10(1):e1003400. doi: 10.1371/journal.pcbi.1003400. Epub 2014 Jan 16.


Functional vacuolar ATPase (V-ATPase) proton pumps traffic to the enterocyte brush border membrane and require CFTR.

Collaco AM, Geibel P, Lee BS, Geibel JP, Ameen NA.

Am J Physiol Cell Physiol. 2013 Nov 1;305(9):C981-96. doi: 10.1152/ajpcell.00067.2013. Epub 2013 Aug 28.


Candida albicans VMA3 is necessary for V-ATPase assembly and function and contributes to secretion and filamentation.

Rane HS, Bernardo SM, Raines SM, Binder JL, Parra KJ, Lee SA.

Eukaryot Cell. 2013 Oct;12(10):1369-82. doi: 10.1128/EC.00118-13. Epub 2013 Aug 2.


A single amino acid substitution in the core protein of West Nile virus increases resistance to acidotropic compounds.

Martín-Acebes MA, Blázquez AB, de Oya NJ, Escribano-Romero E, Shi PY, Saiz JC.

PLoS One. 2013 Jul 18;8(7):e69479. doi: 10.1371/journal.pone.0069479. Print 2013.


Inhibitory and combinatorial effect of diphyllin, a v-ATPase blocker, on influenza viruses.

Chen HW, Cheng JX, Liu MT, King K, Peng JY, Zhang XQ, Wang CH, Shresta S, Schooley RT, Liu YT.

Antiviral Res. 2013 Sep;99(3):371-82. doi: 10.1016/j.antiviral.2013.06.014. Epub 2013 Jun 29.


Intracellular fate of carbon nanotubes inside murine macrophages: pH-dependent detachment of iron catalyst nanoparticles.

Bussy C, Paineau E, Cambedouzou J, Brun N, Mory C, Fayard B, Salomé M, Pinault M, Huard M, Belade E, Armand L, Boczkowski J, Launois P, Lanone S.

Part Fibre Toxicol. 2013 Jun 25;10:24. doi: 10.1186/1743-8977-10-24.


Hypoxic pulmonary vasoconstriction in the absence of pretone: essential role for intracellular Ca2+ release.

Connolly MJ, Prieto-Lloret J, Becker S, Ward JP, Aaronson PI.

J Physiol. 2013 Sep 15;591(Pt 18):4473-98. doi: 10.1113/jphysiol.2013.253682. Epub 2013 Jun 17.


The NuRD complex cooperates with DNMTs to maintain silencing of key colorectal tumor suppressor genes.

Cai Y, Geutjes EJ, de Lint K, Roepman P, Bruurs L, Yu LR, Wang W, van Blijswijk J, Mohammad H, de Rink I, Bernards R, Baylin SB.

Oncogene. 2014 Apr 24;33(17):2157-68. doi: 10.1038/onc.2013.178. Epub 2013 May 27.


The binding site of the V-ATPase inhibitor apicularen is in the vicinity of those for bafilomycin and archazolid.

Osteresch C, Bender T, Grond S, von Zezschwitz P, Kunze B, Jansen R, Huss M, Wieczorek H.

J Biol Chem. 2012 Sep 14;287(38):31866-76. doi: 10.1074/jbc.M112.372169. Epub 2012 Jul 19.

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