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Allosteric modulation of AURKA kinase activity by a small-molecule inhibitor of its protein-protein interaction with TPX2.

Janeček M, Rossmann M, Sharma P, Emery A, Huggins DJ, Stockwell SR, Stokes JE, Tan YS, Almeida EG, Hardwick B, Narvaez AJ, Hyvönen M, Spring DR, McKenzie GJ, Venkitaraman AR.

Sci Rep. 2016 Jun 24;6:28528. doi: 10.1038/srep28528.


Non-centrosomal TPX2-Dependent Regulation of the Aurora A Kinase: Functional Implications for Healthy and Pathological Cell Division.

Garrido G, Vernos I.

Front Oncol. 2016 Apr 15;6:88. doi: 10.3389/fonc.2016.00088. eCollection 2016. Review.


Essential role for a novel population of binucleated mammary epithelial cells in lactation.

Rios AC, Fu NY, Jamieson PR, Pal B, Whitehead L, Nicholas KR, Lindeman GJ, Visvader JE.

Nat Commun. 2016 Apr 22;7:11400. doi: 10.1038/ncomms11400.


Targeting megakaryocytic-induced fibrosis in myeloproliferative neoplasms by AURKA inhibition.

Wen QJ, Yang Q, Goldenson B, Malinge S, Lasho T, Schneider RK, Breyfogle LJ, Schultz R, Gilles L, Koppikar P, Abdel-Wahab O, Pardanani A, Stein B, Gurbuxani S, Mullally A, Levine RL, Tefferi A, Crispino JD.

Nat Med. 2015 Dec;21(12):1473-80. doi: 10.1038/nm.3995. Epub 2015 Nov 16.


Preclinical Childhood Sarcoma Models: Drug Efficacy Biomarker Identification and Validation.

Geier B, Kurmashev D, Kurmasheva RT, Houghton PJ.

Front Oncol. 2015 Aug 26;5:193. doi: 10.3389/fonc.2015.00193. eCollection 2015. Review.


Aurora-A-Dependent Control of TACC3 Influences the Rate of Mitotic Spindle Assembly.

Burgess SG, Peset I, Joseph N, Cavazza T, Vernos I, Pfuhl M, Gergely F, Bayliss R.

PLoS Genet. 2015 Jul 2;11(7):e1005345. doi: 10.1371/journal.pgen.1005345. eCollection 2015 Jul.


The Aurora A-HP1γ pathway regulates gene expression and mitosis in cells from the sperm lineage.

Leonard PH, Grzenda A, Mathison A, Morbeck DE, Fredrickson JR, de Assuncao TM, Christensen T, Salisbury J, Calvo E, Iovanna J, Coddington CC, Urrutia R, Lomberk G.

BMC Dev Biol. 2015 May 29;15:23. doi: 10.1186/s12861-015-0073-x.


Aurora kinase A in gastrointestinal cancers: time to target.

Katsha A, Belkhiri A, Goff L, El-Rifai W.

Mol Cancer. 2015 May 20;14:106. doi: 10.1186/s12943-015-0375-4. Review.


Aurora kinase A is required for hematopoiesis but is dispensable for murine megakaryocyte endomitosis and differentiation.

Goldenson B, Kirsammer G, Stankiewicz MJ, Wen QJ, Crispino JD.

Blood. 2015 Mar 26;125(13):2141-50. doi: 10.1182/blood-2014-12-615401. Epub 2015 Feb 10.


Human Nek7-interactor RGS2 is required for mitotic spindle organization.

de Souza EE, Hehnly H, Perez AM, Meirelles GV, Smetana JH, Doxsey S, Kobarg J.

Cell Cycle. 2015;14(4):656-67. doi: 10.4161/15384101.2014.994988.


The Aurora-A inhibitor MLN8237 affects multiple mitotic processes and induces dose-dependent mitotic abnormalities and aneuploidy.

Asteriti IA, Di Cesare E, De Mattia F, Hilsenstein V, Neumann B, Cundari E, Lavia P, Guarguaglini G.

Oncotarget. 2014 Aug 15;5(15):6229-42.


Microcephaly disease gene Wdr62 regulates mitotic progression of embryonic neural stem cells and brain size.

Chen JF, Zhang Y, Wilde J, Hansen KC, Lai F, Niswander L.

Nat Commun. 2014 May 30;5:3885. doi: 10.1038/ncomms4885.


DNA replication stress in CHK1-depleted tumour cells triggers premature (S-phase) mitosis through inappropriate activation of Aurora kinase B.

Zuazua-Villar P, Rodriguez R, Gagou ME, Eyers PA, Meuth M.

Cell Death Dis. 2014 May 22;5:e1253. doi: 10.1038/cddis.2014.231.


The aurora kinases in cell cycle and leukemia.

Goldenson B, Crispino JD.

Oncogene. 2015 Jan 29;34(5):537-45. doi: 10.1038/onc.2014.14. Epub 2014 Mar 17. Review.


SIRT2 regulates ciliogenesis and contributes to abnormal centrosome amplification caused by loss of polycystin-1.

Zhou X, Fan LX, Li K, Ramchandran R, Calvet JP, Li X.

Hum Mol Genet. 2014 Mar 15;23(6):1644-55. doi: 10.1093/hmg/ddt556. Epub 2013 Nov 7.


The UBXN-2/p37/p47 adaptors of CDC-48/p97 regulate mitosis by limiting the centrosomal recruitment of Aurora A.

Kress E, Schwager F, Holtackers R, Seiler J, Prodon F, Zanin E, Eiteneuer A, Toya M, Sugimoto A, Meyer H, Meraldi P, Gotta M.

J Cell Biol. 2013 May 13;201(4):559-75. doi: 10.1083/jcb.201209107. Epub 2013 May 6.


Mitotic Stress and Chromosomal Instability in Cancer: The Case for TPX2.

Pérez de Castro I, Malumbres M.

Genes Cancer. 2012 Nov;3(11-12):721-30. doi: 10.1177/1947601912473306.


Aurora at the pole and equator: overlapping functions of Aurora kinases in the mitotic spindle.

Hochegger H, Hégarat N, Pereira-Leal JB.

Open Biol. 2013 Mar 20;3(3):120185. doi: 10.1098/rsob.120185. Review.


DNA damage associated with mitosis and cytokinesis failure.

Hayashi MT, Karlseder J.

Oncogene. 2013 Sep 26;32(39):4593-601. doi: 10.1038/onc.2012.615. Epub 2013 Jan 14. Review.

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