Display Settings:

Format
Items per page
Sort by

Send to:

Choose Destination

Results: 19

1.

The human orphan nuclear receptor tailless (TLX, NR2E1) is druggable.

Benod C, Villagomez R, Filgueira CS, Hwang PK, Leonard PG, Poncet-Montange G, Rajagopalan S, Fletterick RJ, Gustafsson JÅ, Webb P.

PLoS One. 2014 Jun 17;9(6):e99440. doi: 10.1371/journal.pone.0099440. eCollection 2014.

PMID:
24936658
[PubMed - in process]
Free PMC Article
2.

Structural insights into gene repression by the orphan nuclear receptor SHP.

Zhi X, Zhou XE, He Y, Zechner C, Suino-Powell KM, Kliewer SA, Melcher K, Mangelsdorf DJ, Xu HE.

Proc Natl Acad Sci U S A. 2014 Jan 14;111(2):839-44. doi: 10.1073/pnas.1322827111. Epub 2013 Dec 30. Erratum in: Proc Natl Acad Sci U S A. 2014 Mar 11;111(10):3895.

PMID:
24379397
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

The crystal structure of the orphan nuclear receptor NR2E3/PNR ligand binding domain reveals a dimeric auto-repressed conformation.

Tan MH, Zhou XE, Soon FF, Li X, Li J, Yong EL, Melcher K, Xu HE.

PLoS One. 2013 Sep 12;8(9):e74359. doi: 10.1371/journal.pone.0074359. eCollection 2013.

PMID:
24069298
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Structure-based discovery of antagonists of nuclear receptor LRH-1.

Benod C, Carlsson J, Uthayaruban R, Hwang P, Irwin JJ, Doak AK, Shoichet BK, Sablin EP, Fletterick RJ.

J Biol Chem. 2013 Jul 5;288(27):19830-44. doi: 10.1074/jbc.M112.411686. Epub 2013 May 10.

PMID:
23667258
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

The orphan nuclear receptor DAX-1 functions as a potent corepressor of the constitutive androstane receptor (NR1I3).

Laurenzana EM, Chen T, Kannuswamy M, Sell BE, Strom SC, Li Y, Omiecinski CJ.

Mol Pharmacol. 2012 Nov;82(5):918-28. doi: 10.1124/mol.112.080721. Epub 2012 Aug 15.

PMID:
22896671
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Antidiabetic phospholipid-nuclear receptor complex reveals the mechanism for phospholipid-driven gene regulation.

Musille PM, Pathak MC, Lauer JL, Hudson WH, Griffin PR, Ortlund EA.

Nat Struct Mol Biol. 2012 Apr 15;19(5):532-7, S1-2. doi: 10.1038/nsmb.2279.

PMID:
22504882
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Structural basis of coactivation of liver receptor homolog-1 by β-catenin.

Yumoto F, Nguyen P, Sablin EP, Baxter JD, Webb P, Fletterick RJ.

Proc Natl Acad Sci U S A. 2012 Jan 3;109(1):143-8. doi: 10.1073/pnas.1117036108. Epub 2011 Dec 20.

PMID:
22187462
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Nuclear receptor liver receptor homologue 1 (LRH-1) regulates pancreatic cancer cell growth and proliferation.

Benod C, Vinogradova MV, Jouravel N, Kim GE, Fletterick RJ, Sablin EP.

Proc Natl Acad Sci U S A. 2011 Oct 11;108(41):16927-31. doi: 10.1073/pnas.1112047108. Epub 2011 Sep 26.

PMID:
21949357
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Emerging actions of the nuclear receptor LRH-1 in the gut.

Fernandez-Marcos PJ, Auwerx J, Schoonjans K.

Biochim Biophys Acta. 2011 Aug;1812(8):947-55. doi: 10.1016/j.bbadis.2010.12.010. Epub 2010 Dec 29. Review.

PMID:
21194563
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

The orphan nuclear receptor TR4 is a vitamin A-activated nuclear receptor.

Zhou XE, Suino-Powell KM, Xu Y, Chan CW, Tanabe O, Kruse SW, Reynolds R, Engel JD, Xu HE.

J Biol Chem. 2011 Jan 28;286(4):2877-85. doi: 10.1074/jbc.M110.168740. Epub 2010 Nov 9.

PMID:
21068381
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Dax1 up-regulates Oct4 expression in mouse embryonic stem cells via LRH-1 and SRA.

Kelly VR, Xu B, Kuick R, Koenig RJ, Hammer GD.

Mol Endocrinol. 2010 Dec;24(12):2281-91. doi: 10.1210/me.2010-0133. Epub 2010 Oct 13.

PMID:
20943815
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Structural and functional insights into nuclear receptor signaling.

Jin L, Li Y.

Adv Drug Deliv Rev. 2010 Oct 30;62(13):1218-26. doi: 10.1016/j.addr.2010.08.007. Epub 2010 Aug 17. Review.

PMID:
20723571
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Novel polymorphisms of nuclear receptor SHP associated with functional and structural changes.

Zhou T, Zhang Y, Macchiarulo A, Yang Z, Cellanetti M, Coto E, Xu P, Pellicciari R, Wang L.

J Biol Chem. 2010 Aug 6;285(32):24871-81. doi: 10.1074/jbc.M110.133280. Epub 2010 Jun 1.

PMID:
20516075
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Hormone binding and co-regulator binding to the glucocorticoid receptor are allosterically coupled.

Pfaff SJ, Fletterick RJ.

J Biol Chem. 2010 May 14;285(20):15256-67. doi: 10.1074/jbc.M110.108118. Epub 2010 Mar 24.

PMID:
20335180
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Nuclear hormone receptor architecture - form and dynamics: The 2009 FASEB Summer Conference on Dynamic Structure of the Nuclear Hormone Receptors.

McEwan IJ, Nardulli AM.

Nucl Recept Signal. 2009 Dec 31;7:e011. doi: 10.1621/nrs.07011.

PMID:
20087432
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Orphan nuclear receptor DAX-1 acts as a novel corepressor of liver X receptor alpha and inhibits hepatic lipogenesis.

Nedumaran B, Kim GS, Hong S, Yoon YS, Kim YH, Lee CH, Lee YC, Koo SH, Choi HS.

J Biol Chem. 2010 Mar 19;285(12):9221-32. doi: 10.1074/jbc.M109.073650. Epub 2010 Jan 15.

PMID:
20080977
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Tris-nitrilotriacetic acids of subnanomolar affinity toward hexahistidine tagged molecules.

Huang Z, Hwang P, Watson DS, Cao L, Szoka FC Jr.

Bioconjug Chem. 2009 Aug 19;20(8):1667-72. doi: 10.1021/bc900309n. Epub 2009 Aug 3.

PMID:
19650657
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

E3 ubiquitin ligase RNF31 cooperates with DAX-1 in transcriptional repression of steroidogenesis.

Ehrlund A, Anthonisen EH, Gustafsson N, Venteclef N, Robertson Remen K, Damdimopoulos AE, Galeeva A, Pelto-Huikko M, Lalli E, Steffensen KR, Gustafsson JA, Treuter E.

Mol Cell Biol. 2009 Apr;29(8):2230-42. doi: 10.1128/MCB.00743-08. Epub 2009 Feb 23.

PMID:
19237537
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Structure of SF-1 bound by different phospholipids: evidence for regulatory ligands.

Sablin EP, Blind RD, Krylova IN, Ingraham JG, Cai F, Williams JD, Fletterick RJ, Ingraham HA.

Mol Endocrinol. 2009 Jan;23(1):25-34. doi: 10.1210/me.2007-0508. Epub 2008 Nov 6.

PMID:
18988706
[PubMed - indexed for MEDLINE]
Free PMC Article

Display Settings:

Format
Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

Write to the Help Desk