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Items: 14

1.

A C-14 labeled Py-Im polyamide localizes to a subcutaneous prostate cancer tumor.

Raskatov JA, Puckett JW, Dervan PB.

Bioorg Med Chem. 2014 Aug 15;22(16):4371-5. doi: 10.1016/j.bmc.2014.04.010. Epub 2014 Apr 16.

2.

Binding studies of a large antiviral polyamide to a natural HPV sequence.

He G, Vasilieva E, Harris GD Jr, Koeller KJ, Bashkin JK, Dupureur CM.

Biochimie. 2014 Jul;102:83-91. doi: 10.1016/j.biochi.2014.02.011. Epub 2014 Feb 26.

3.

Animal toxicity of hairpin pyrrole-imidazole polyamides varies with the turn unit.

Yang F, Nickols NG, Li BC, Szablowski JO, Hamilton SR, Meier JL, Wang CM, Dervan PB.

J Med Chem. 2013 Sep 26;56(18):7449-57. doi: 10.1021/jm401100s. Epub 2013 Sep 9.

4.

Structure-based DNA-targeting strategies with small molecule ligands for drug discovery.

Sheng J, Gan J, Huang Z.

Med Res Rev. 2013 Sep;33(5):1119-73. doi: 10.1002/med.21278. Epub 2013 Apr 30. Review.

5.

Promoter scanning of the human COX-2 gene with 8-ring polyamides: unexpected weakening of polyamide-DNA binding and selectivity by replacing an internal N-Me-pyrrole with β-alanine.

Bashkin JK, Aston K, Ramos JP, Koeller KJ, Nanjunda R, He G, Dupureur CM, David Wilson W.

Biochimie. 2013 Feb;95(2):271-9. doi: 10.1016/j.biochi.2012.09.023. Epub 2012 Sep 27.

6.

Single-dose pharmacokinetic and toxicity analysis of pyrrole-imidazole polyamides in mice.

Synold TW, Xi B, Wu J, Yen Y, Li BC, Yang F, Phillips JW, Nickols NG, Dervan PB.

Cancer Chemother Pharmacol. 2012 Oct;70(4):617-25. Epub 2012 Aug 21.

7.

Characterization and solubilization of pyrrole-imidazole polyamide aggregates.

Hargrove AE, Raskatov JA, Meier JL, Montgomery DC, Dervan PB.

J Med Chem. 2012 Jun 14;55(11):5425-32. doi: 10.1021/jm300380a. Epub 2012 May 24.

8.

Microwave assisted synthesis of Py-Im polyamides.

Puckett JW, Green JT, Dervan PB.

Org Lett. 2012 Jun 1;14(11):2774-7. doi: 10.1021/ol3010003. Epub 2012 May 11.

9.

Pharmacokinetics of Py-Im polyamides depend on architecture: cyclic versus linear.

Raskatov JA, Hargrove AE, So AY, Dervan PB.

J Am Chem Soc. 2012 May 9;134(18):7995-9. doi: 10.1021/ja302588v. Epub 2012 Apr 24.

10.

Fluoride-18 radiolabeling of peptides bearing an aminooxy functional group to a prosthetic ligand via an oxime bond.

Carberry P, Carpenter AP, Kung HF.

Bioorg Med Chem Lett. 2011 Dec 1;21(23):6992-5. doi: 10.1016/j.bmcl.2011.09.124. Epub 2011 Oct 5.

11.

HPV episome levels are potently decreased by pyrrole-imidazole polyamides.

Edwards TG, Koeller KJ, Slomczynska U, Fok K, Helmus M, Bashkin JK, Fisher C.

Antiviral Res. 2011 Aug;91(2):177-86. doi: 10.1016/j.antiviral.2011.05.014. Epub 2011 Jun 2.

12.

Structural basis for cyclic Py-Im polyamide allosteric inhibition of nuclear receptor binding.

Chenoweth DM, Dervan PB.

J Am Chem Soc. 2010 Oct 20;132(41):14521-9. doi: 10.1021/ja105068b.

13.

Modifications at the C-terminus to improve pyrrole-imidazole polyamide activity in cell culture.

Jacobs CS, Dervan PB.

J Med Chem. 2009 Dec 10;52(23):7380-8. doi: 10.1021/jm900256f.

14.

Cyclic pyrrole-imidazole polyamides targeted to the androgen response element.

Chenoweth DM, Harki DA, Phillips JW, Dose C, Dervan PB.

J Am Chem Soc. 2009 May 27;131(20):7182-8. doi: 10.1021/ja901309z.

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