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Items: 1 to 20 of 54


The Rap1-RIAM pathway prefers β2 integrins.

Calderwood DA.

Blood. 2015 Dec 17;126(25):2658-9. doi: 10.1182/blood-2015-09-668962. No abstract available.


A RIAM/lamellipodin-talin-integrin complex forms the tip of sticky fingers that guide cell migration.

Lagarrigue F, Vikas Anekal P, Lee HS, Bachir AI, Ablack JN, Horwitz AF, Ginsberg MH.

Nat Commun. 2015 Sep 30;6:8492. doi: 10.1038/ncomms9492.


Integrin associated proteins differentially regulate neutrophil polarity and directed migration in 2D and 3D.

Yamahashi Y, Cavnar PJ, Hind LE, Berthier E, Bennin DA, Beebe D, Huttenlocher A.

Biomed Microdevices. 2015 Oct;17(5):100. doi: 10.1007/s10544-015-9998-x.


Loss of the Rap1 effector RIAM results in leukocyte adhesion deficiency due to impaired β2 integrin function in mice.

Klapproth S, Sperandio M, Pinheiro EM, Prünster M, Soehnlein O, Gertler FB, Fässler R, Moser M.

Blood. 2015 Dec 17;126(25):2704-12. doi: 10.1182/blood-2015-05-647453. Epub 2015 Sep 3.


Rap1 and its effector RIAM are required for lymphocyte trafficking.

Su W, Wynne J, Pinheiro EM, Strazza M, Mor A, Montenont E, Berger J, Paul DS, Bergmeier W, Gertler FB, Philips MR.

Blood. 2015 Dec 17;126(25):2695-703. doi: 10.1182/blood-2015-05-644104. Epub 2015 Aug 31.


Conformational activation of talin by RIAM triggers integrin-mediated cell adhesion.

Yang J, Zhu L, Zhang H, Hirbawi J, Fukuda K, Dwivedi P, Liu J, Byzova T, Plow EF, Wu J, Qin J.

Nat Commun. 2014 Dec 18;5:5880. doi: 10.1038/ncomms6880.


Structural and mechanistic insights into the recruitment of talin by RIAM in integrin signaling.

Chang YC, Zhang H, Franco-Barraza J, Brennan ML, Patel T, Cukierman E, Wu J.

Structure. 2014 Dec 2;22(12):1810-20. doi: 10.1016/j.str.2014.09.020. Epub 2014 Nov 20.


Rap1-GTP-interacting adaptor molecule (RIAM) is dispensable for platelet integrin activation and function in mice.

Stritt S, Wolf K, Lorenz V, Vögtle T, Gupta S, Bösl MR, Nieswandt B.

Blood. 2015 Jan 8;125(2):219-22. doi: 10.1182/blood-2014-08-597542. Epub 2014 Oct 21.


MIG-10 (Lamellipodin) stabilizes invading cell adhesion to basement membrane and is a negative transcriptional target of EGL-43 in C. elegans.

Wang L, Shen W, Lei S, Matus D, Sherwood D, Wang Z.

Biochem Biophys Res Commun. 2014 Sep 26;452(3):328-33. doi: 10.1016/j.bbrc.2014.08.049. Epub 2014 Aug 19.


Platelet 12-LOX is essential for FcγRIIa-mediated platelet activation.

Yeung J, Tourdot BE, Fernandez-Perez P, Vesci J, Ren J, Smyrniotis CJ, Luci DK, Jadhav A, Simeonov A, Maloney DJ, Holman TR, McKenzie SE, Holinstat M.

Blood. 2014 Oct 2;124(14):2271-9. doi: 10.1182/blood-2014-05-575878. Epub 2014 Aug 6.


Intermolecular transmembrane domain interactions activate integrin αIIbβ3.

Ye F, Kim SJ, Kim C.

J Biol Chem. 2014 Jun 27;289(26):18507-13. doi: 10.1074/jbc.M113.541888. Epub 2014 May 16.


The Ras-related protein, Rap1A, mediates thrombin-stimulated, integrin-dependent glioblastoma cell proliferation and tumor growth.

Sayyah J, Bartakova A, Nogal N, Quilliam LA, Stupack DG, Brown JH.

J Biol Chem. 2014 Jun 20;289(25):17689-98. doi: 10.1074/jbc.M113.536227. Epub 2014 May 1.


ADAP interactions with talin and kindlin promote platelet integrin αIIbβ3 activation and stable fibrinogen binding.

Kasirer-Friede A, Kang J, Kahner B, Ye F, Ginsberg MH, Shattil SJ.

Blood. 2014 May 15;123(20):3156-65. doi: 10.1182/blood-2013-08-520627. Epub 2014 Feb 12.


The N terminus of SKAP55 enables T cell adhesion to TCR and integrin ligands via distinct mechanisms.

Ophir MJ, Liu BC, Bunnell SC.

J Cell Biol. 2013 Dec 23;203(6):1021-41. doi: 10.1083/jcb.201305088.


Talins and kindlins: partners in integrin-mediated adhesion.

Calderwood DA, Campbell ID, Critchley DR.

Nat Rev Mol Cell Biol. 2013 Aug;14(8):503-17. doi: 10.1038/nrm3624. Epub 2013 Jul 17. Review.


Structural studies on full-length talin1 reveal a compact auto-inhibited dimer: implications for talin activation.

Goult BT, Xu XP, Gingras AR, Swift M, Patel B, Bate N, Kopp PM, Barsukov IL, Critchley DR, Volkmann N, Hanein D.

J Struct Biol. 2013 Oct;184(1):21-32. doi: 10.1016/j.jsb.2013.05.014. Epub 2013 May 30.


Two modes of integrin activation form a binary molecular switch in adhesion maturation.

Lee HS, Anekal P, Lim CJ, Liu CC, Ginsberg MH.

Mol Biol Cell. 2013 May;24(9):1354-62. doi: 10.1091/mbc.E12-09-0695. Epub 2013 Mar 6.


RIAM and vinculin binding to talin are mutually exclusive and regulate adhesion assembly and turnover.

Goult BT, Zacharchenko T, Bate N, Tsang R, Hey F, Gingras AR, Elliott PR, Roberts GC, Ballestrem C, Critchley DR, Barsukov IL.

J Biol Chem. 2013 Mar 22;288(12):8238-49. doi: 10.1074/jbc.M112.438119. Epub 2013 Feb 6.


Talin1 has unique expression versus talin 2 in the heart and modifies the hypertrophic response to pressure overload.

Manso AM, Li R, Monkley SJ, Cruz NM, Ong S, Lao DH, Koshman YE, Gu Y, Peterson KL, Chen J, Abel ED, Samarel AM, Critchley DR, Ross RS.

J Biol Chem. 2013 Feb 8;288(6):4252-64. doi: 10.1074/jbc.M112.427484. Epub 2012 Dec 24.


Rap1 can bypass the FAK-Src-Paxillin cascade to induce cell spreading and focal adhesion formation.

Ross SH, Spanjaard E, Post A, Vliem MJ, Kristyanto H, Bos JL, de Rooij J.

PLoS One. 2012;7(11):e50072. doi: 10.1371/journal.pone.0050072. Epub 2012 Nov 27.

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