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Results: 17

1.

Hepatoprotective effect of silymarin.

Vargas-Mendoza N, Madrigal-Santillán E, Morales-González A, Esquivel-Soto J, Esquivel-Chirino C, García-Luna Y González-Rubio M, Gayosso-de-Lucio JA, Morales-González JA.

World J Hepatol. 2014 Mar 27;6(3):144-9. doi: 10.4254/wjh.v6.i3.144. Review.

PMID:
24672644
[PubMed]
Free PMC Article
2.

Effects of milk thistle seed against aflatoxin B1 in broiler model.

Amiridumari H, Sarir H, Afzali N, Fanimakki O.

J Res Med Sci. 2013 Sep;18(9):786-90.

PMID:
24381623
[PubMed]
Free PMC Article
3.

An assessment of pharmacokinetics and antioxidant activity of free silymarin flavonolignans in healthy volunteers: a dose escalation study.

Zhu HJ, Brinda BJ, Chavin KD, Bernstein HJ, Patrick KS, Markowitz JS.

Drug Metab Dispos. 2013 Sep;41(9):1679-85. doi: 10.1124/dmd.113.052423. Epub 2013 Jul 8.

PMID:
23835761
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

A systematic approach to evaluate herb-drug interaction mechanisms: investigation of milk thistle extracts and eight isolated constituents as CYP3A inhibitors.

Brantley SJ, Graf TN, Oberlies NH, Paine MF.

Drug Metab Dispos. 2013 Sep;41(9):1662-70. doi: 10.1124/dmd.113.052563. Epub 2013 Jun 25.

PMID:
23801821
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Hepatoprotective and antiviral functions of silymarin components in hepatitis C virus infection.

Polyak SJ, Ferenci P, Pawlotsky JM.

Hepatology. 2013 Mar;57(3):1262-71. doi: 10.1002/hep.26179. Review. No abstract available.

PMID:
23213025
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Silymarin for HCV infection.

Polyak SJ, Oberlies NH, Pécheur EI, Dahari H, Ferenci P, Pawlotsky JM.

Antivir Ther. 2013;18(2):141-7. doi: 10.3851/IMP2402. Epub 2012 Sep 25. Review.

PMID:
23011959
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Drug disposition in pathophysiological conditions.

Gandhi A, Moorthy B, Ghose R.

Curr Drug Metab. 2012 Nov;13(9):1327-44. Review.

PMID:
22746301
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Rationale, challenges, and participants in a Phase II trial of a botanical product for chronic hepatitis C.

Reddy KR, Belle SH, Fried MW, Afdhal N, Navarro VJ, Hawke RL, Wahed AS, Doo E, Meyers CM; SyNCH Study Group.

Clin Trials. 2012 Feb;9(1):102-12. doi: 10.1177/1740774511427064. Epub 2011 Nov 4.

PMID:
22058086
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Differences in the disposition of silymarin between patients with nonalcoholic fatty liver disease and chronic hepatitis C.

Schrieber SJ, Hawke RL, Wen Z, Smith PC, Reddy KR, Wahed AS, Belle SH, Afdhal NH, Navarro VJ, Meyers CM, Doo E, Fried MW.

Drug Metab Dispos. 2011 Dec;39(12):2182-90. doi: 10.1124/dmd.111.040212. Epub 2011 Aug 24.

PMID:
21865319
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Silybin and the liver: from basic research to clinical practice.

Loguercio C, Festi D.

World J Gastroenterol. 2011 May 14;17(18):2288-301. doi: 10.3748/wjg.v17.i18.2288. Review.

PMID:
21633595
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Inhibitory effects of commonly used herbal extracts on UDP-glucuronosyltransferase 1A4, 1A6, and 1A9 enzyme activities.

Mohamed ME, Frye RF.

Drug Metab Dispos. 2011 Sep;39(9):1522-8. doi: 10.1124/dmd.111.039602. Epub 2011 Jun 1.

PMID:
21632963
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Silymarin use and liver disease progression in the Hepatitis C Antiviral Long-Term Treatment against Cirrhosis trial.

Freedman ND, Curto TM, Morishima C, Seeff LB, Goodman ZD, Wright EC, Sinha R, Everhart JE; HALT-C Trial Group.

Aliment Pharmacol Ther. 2011 Jan;33(1):127-37. doi: 10.1111/j.1365-2036.2010.04503.x. Epub 2010 Nov 2.

PMID:
21083592
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Two flavonolignans from milk thistle (Silybum marianum) inhibit CYP2C9-mediated warfarin metabolism at clinically achievable concentrations.

Brantley SJ, Oberlies NH, Kroll DJ, Paine MF.

J Pharmacol Exp Ther. 2010 Mar;332(3):1081-7. doi: 10.1124/jpet.109.161927. Epub 2009 Nov 24.

PMID:
19934397
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Silymarin ascending multiple oral dosing phase I study in noncirrhotic patients with chronic hepatitis C.

Hawke RL, Schrieber SJ, Soule TA, Wen Z, Smith PC, Reddy KR, Wahed AS, Belle SH, Afdhal NH, Navarro VJ, Berman J, Liu QY, Doo E, Fried MW; SyNCH Trial Group.

J Clin Pharmacol. 2010 Apr;50(4):434-49. doi: 10.1177/0091270009347475. Epub 2009 Oct 19.

PMID:
19841158
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Silymarin inhibits in vitro T-cell proliferation and cytokine production in hepatitis C virus infection.

Morishima C, Shuhart MC, Wang CC, Paschal DM, Apodaca MC, Liu Y, Sloan DD, Graf TN, Oberlies NH, Lee DY, Jerome KR, Polyak SJ.

Gastroenterology. 2010 Feb;138(2):671-81, 681.e1-2. doi: 10.1053/j.gastro.2009.09.021. Epub 2009 Sep 24.

PMID:
19782083
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Population pharmacokinetics of sirolimus in de novo Chinese adult renal transplant patients.

Jiao Z, Shi XJ, Li ZD, Zhong MK.

Br J Clin Pharmacol. 2009 Jul;68(1):47-60. doi: 10.1111/j.1365-2125.2009.03392.x.

PMID:
19660003
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Hepatic metabolism and biliary excretion of silymarin flavonolignans in isolated perfused rat livers: role of multidrug resistance-associated protein 2 (Abcc2).

Miranda SR, Lee JK, Brouwer KL, Wen Z, Smith PC, Hawke RL.

Drug Metab Dispos. 2008 Nov;36(11):2219-26. doi: 10.1124/dmd.108.021790. Epub 2008 Aug 7.

PMID:
18687803
[PubMed - indexed for MEDLINE]
Free PMC Article

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