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Results: 19

1.

Site-specific Genome Editing in PBMCs With PLGA Nanoparticle-delivered PNAs Confers HIV-1 Resistance in Humanized Mice.

Schleifman EB, McNeer NA, Jackson A, Yamtich J, Brehm MA, Shultz LD, Greiner DL, Kumar P, Saltzman WM, Glazer PM.

Mol Ther Nucleic Acids. 2013 Nov 19;2:e135. doi: 10.1038/mtna.2013.59.

PMID:
24253260
[PubMed]
Free PMC Article
2.

Diabetes-related impairment in bone strength is established early in the life course.

Casazza K, Hanks LJ, Clines GA, Tse HM, Eberhardt AW.

World J Diabetes. 2013 Aug 15;4(4):145-50. doi: 10.4239/wjd.v4.i4.145.

PMID:
23961325
[PubMed]
Free PMC Article
3.

Human mesenchymal stem cells suppress donor CD4(+) T cell proliferation and reduce pathology in a humanized mouse model of acute graft-versus-host disease.

Tobin LM, Healy ME, English K, Mahon BP.

Clin Exp Immunol. 2013 May;172(2):333-48. doi: 10.1111/cei.12056.

PMID:
23574329
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Systemic delivery of triplex-forming PNA and donor DNA by nanoparticles mediates site-specific genome editing of human hematopoietic cells in vivo.

McNeer NA, Schleifman EB, Cuthbert A, Brehm M, Jackson A, Cheng C, Anandalingam K, Kumar P, Shultz LD, Greiner DL, Mark Saltzman W, Glazer PM.

Gene Ther. 2013 Jun;20(6):658-69. doi: 10.1038/gt.2012.82. Epub 2012 Oct 18.

PMID:
23076379
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Comparison of hematopoietic stem cells derived from fresh and cryopreserved whole cord blood in the generation of humanized mice.

Scholbach J, Schulz A, Westphal F, Egger D, Wege AK, Patties I, Köberle M, Sack U, Lange F.

PLoS One. 2012;7(10):e46772. doi: 10.1371/journal.pone.0046772. Epub 2012 Oct 11.

PMID:
23071634
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Development of a new humanized mouse model to study acute inflammatory arthritis.

Misharin AV, Haines GK 3rd, Rose S, Gierut AK, Hotchkiss RS, Perlman H.

J Transl Med. 2012 Sep 13;10:190. doi: 10.1186/1479-5876-10-190.

PMID:
22974474
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Advancing animal models of human type 1 diabetes by engraftment of functional human tissues in immunodeficient mice.

Brehm MA, Powers AC, Shultz LD, Greiner DL.

Cold Spring Harb Perspect Med. 2012 May;2(5):a007757. doi: 10.1101/cshperspect.a007757. Review.

PMID:
22553498
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Immune mechanisms of Concanavalin A model of autoimmune hepatitis.

Wang HX, Liu M, Weng SY, Li JJ, Xie C, He HL, Guan W, Yuan YS, Gao J.

World J Gastroenterol. 2012 Jan 14;18(2):119-25. doi: 10.3748/wjg.v18.i2.119. Review.

PMID:
22253517
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Engraftment of human HSCs in nonirradiated newborn NOD-scid IL2rγ null mice is enhanced by transgenic expression of membrane-bound human SCF.

Brehm MA, Racki WJ, Leif J, Burzenski L, Hosur V, Wetmore A, Gott B, Herlihy M, Ignotz R, Dunn R, Shultz LD, Greiner DL.

Blood. 2012 Mar 22;119(12):2778-88. doi: 10.1182/blood-2011-05-353243. Epub 2012 Jan 12.

PMID:
22246028
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Can humanized mice reflect the complex pathobiology of HIV-associated neurocognitive disorders?

Gorantla S, Gendelman HE, Poluektova LY.

J Neuroimmune Pharmacol. 2012 Jun;7(2):352-62. doi: 10.1007/s11481-011-9335-y. Epub 2012 Jan 7. Review.

PMID:
22222956
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Human islet cell MORF/cMORF pretargeting in a xenogeneic murine transplant model.

Liu G, Dou S, Cheng D, Leif J, Rusckowski M, Streeter PR, Shultz LD, Hnatowich DJ, Greiner DL.

Mol Pharm. 2011 Jun 6;8(3):767-73. doi: 10.1021/mp100382m. Epub 2011 Apr 21.

PMID:
21361360
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

The new generation of beta-cells: replication, stem cell differentiation, and the role of small molecules.

Borowiak M.

Rev Diabet Stud. 2010 Summer;7(2):93-104. doi: 10.1900/RDS.2010.7.93. Epub 2010 Aug 10. Review.

PMID:
21060968
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Humanized nonobese diabetic-scid IL2rgammanull mice are susceptible to lethal Salmonella Typhi infection.

Libby SJ, Brehm MA, Greiner DL, Shultz LD, McClelland M, Smith KD, Cookson BT, Karlinsey JE, Kinkel TL, Porwollik S, Canals R, Cummings LA, Fang FC.

Proc Natl Acad Sci U S A. 2010 Aug 31;107(35):15589-94. doi: 10.1073/pnas.1005566107. Epub 2010 Aug 16.

PMID:
20713716
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Human immune system development and rejection of human islet allografts in spontaneously diabetic NOD-Rag1null IL2rgammanull Ins2Akita mice.

Brehm MA, Bortell R, Diiorio P, Leif J, Laning J, Cuthbert A, Yang C, Herlihy M, Burzenski L, Gott B, Foreman O, Powers AC, Greiner DL, Shultz LD.

Diabetes. 2010 Sep;59(9):2265-70. doi: 10.2337/db10-0323. Epub 2010 Jun 22.

PMID:
20570944
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Humanized mouse models to study human diseases.

Brehm MA, Shultz LD, Greiner DL.

Curr Opin Endocrinol Diabetes Obes. 2010 Apr;17(2):120-5. doi: 10.1097/MED.0b013e328337282f.

PMID:
20150806
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

NOD-scid IL2rgamma(null) mouse model of human skin transplantation and allograft rejection.

Racki WJ, Covassin L, Brehm M, Pino S, Ignotz R, Dunn R, Laning J, Graves SK, Rossini AA, Shultz LD, Greiner DL.

Transplantation. 2010 Mar 15;89(5):527-36. doi: 10.1097/TP.0b013e3181c90242.

PMID:
20134397
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Parameters for establishing humanized mouse models to study human immunity: analysis of human hematopoietic stem cell engraftment in three immunodeficient strains of mice bearing the IL2rgamma(null) mutation.

Brehm MA, Cuthbert A, Yang C, Miller DM, DiIorio P, Laning J, Burzenski L, Gott B, Foreman O, Kavirayani A, Herlihy M, Rossini AA, Shultz LD, Greiner DL.

Clin Immunol. 2010 Apr;135(1):84-98. doi: 10.1016/j.clim.2009.12.008. Epub 2010 Jan 21.

PMID:
20096637
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Bioluminescent imaging demonstrates that transplanted human embryonic stem cell-derived CD34(+) cells preferentially develop into endothelial cells.

Tian X, Hexum MK, Penchev VR, Taylor RJ, Shultz LD, Kaufman DS.

Stem Cells. 2009 Nov;27(11):2675-85. doi: 10.1002/stem.204.

PMID:
19711457
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Use of humanized severe combined immunodeficient mice for human vaccine development.

Koo GC, Hasan A, O'Reilly RJ.

Expert Rev Vaccines. 2009 Jan;8(1):113-20. doi: 10.1586/14760584.8.1.113. Review.

PMID:
19093778
[PubMed - indexed for MEDLINE]
Free PMC Article
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