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Huwe1 interacts with Gadd45b under oxygen-glucose deprivation and reperfusion injury in primary Rat cortical neuronal cells.

He GQ, Xu WM, Li JF, Li SS, Liu B, Tan XD, Li CQ.

Mol Brain. 2015 Dec 23;8:88. doi: 10.1186/s13041-015-0178-y.


The role of the ubiquitin proteasome system in cerebellar development and medulloblastoma.

Vriend J, Ghavami S, Marzban H.

Mol Brain. 2015 Oct 17;8(1):64. doi: 10.1186/s13041-015-0155-5. Review.


Regulation of c-Myc expression by the histone demethylase JMJD1A is essential for prostate cancer cell growth and survival.

Fan L, Peng G, Sahgal N, Fazli L, Gleave M, Zhang Y, Hussain A, Qi J.

Oncogene. 2016 May 12;35(19):2441-52. doi: 10.1038/onc.2015.309. Epub 2015 Aug 17.


New insights into craniofacial malformations.

Twigg SR, Wilkie AO.

Hum Mol Genet. 2015 Oct 15;24(R1):R50-9. doi: 10.1093/hmg/ddv228. Epub 2015 Jun 17. Review.


DNA damage-induced activation of CUL4B targets HUWE1 for proteasomal degradation.

Yi J, Lu G, Li L, Wang X, Cao L, Lin M, Zhang S, Shao G.

Nucleic Acids Res. 2015 May 19;43(9):4579-90. doi: 10.1093/nar/gkv325. Epub 2015 Apr 16.


Tumor cell-specific inhibition of MYC function using small molecule inhibitors of the HUWE1 ubiquitin ligase.

Peter S, Bultinck J, Myant K, Jaenicke LA, Walz S, Müller J, Gmachl M, Treu M, Boehmelt G, Ade CP, Schmitz W, Wiegering A, Otto C, Popov N, Sansom O, Kraut N, Eilers M.

EMBO Mol Med. 2014 Sep 24;6(12):1525-41. doi: 10.15252/emmm.201403927.


PKD1 phosphorylation-dependent degradation of SNAIL by SCF-FBXO11 regulates epithelial-mesenchymal transition and metastasis.

Zheng H, Shen M, Zha YL, Li W, Wei Y, Blanco MA, Ren G, Zhou T, Storz P, Wang HY, Kang Y.

Cancer Cell. 2014 Sep 8;26(3):358-73. doi: 10.1016/j.ccr.2014.07.022.


Quantitative Lys-ϵ-Gly-Gly (diGly) proteomics coupled with inducible RNAi reveals ubiquitin-mediated proteolysis of DNA damage-inducible transcript 4 (DDIT4) by the E3 ligase HUWE1.

Thompson JW, Nagel J, Hoving S, Gerrits B, Bauer A, Thomas JR, Kirschner MW, Schirle M, Luchansky SJ.

J Biol Chem. 2014 Oct 17;289(42):28942-55. doi: 10.1074/jbc.M114.573352. Epub 2014 Aug 21.


HUWE1 is a molecular link controlling RAF-1 activity supported by the Shoc2 scaffold.

Jang ER, Shi P, Bryant J, Chen J, Dukhande V, Gentry MS, Jang H, Jeoung M, Galperin E.

Mol Cell Biol. 2014 Oct 1;34(19):3579-93. doi: 10.1128/MCB.00811-14. Epub 2014 Jul 14.


MYC cofactors: molecular switches controlling diverse biological outcomes.

Hann SR.

Cold Spring Harb Perspect Med. 2014 Jun 17;4(9):a014399. doi: 10.1101/cshperspect.a014399. Review.


Regulation of stem cell function by protein ubiquitylation.

Strikoudis A, Guillamot M, Aifantis I.

EMBO Rep. 2014 Apr;15(4):365-82. doi: 10.1002/embr.201338373. Epub 2014 Mar 20. Review.


Myc and differentiation: going against the current.

Iavarone A, Lasorella A.

EMBO Rep. 2014 Apr;15(4):324-5. doi: 10.1002/embr.201438509. Epub 2014 Mar 10. No abstract available.


Homeostatic defects in B cells deficient in the E3 ubiquitin ligase ARF-BP1 are restored by enhanced expression of MYC.

Qi CF, Zhang R, Sun J, Li Z, Shin DM, Wang H, Kovalchuk AL, Sakai T, Xiong H, Kon N, Gu W, Morse HC 3rd.

Leuk Res. 2013 Dec;37(12):1680-9. doi: 10.1016/j.leukres.2013.09.009. Epub 2013 Sep 20.


Identification of GABA(C) receptor protein homeostasis network components from three tandem mass spectrometry proteomics approaches.

Wang YJ, Han DY, Tabib T, Yates JR 3rd, Mu TW.

J Proteome Res. 2013 Dec 6;12(12):5570-86. doi: 10.1021/pr400535z. Epub 2013 Oct 11.


New strategies in neuroblastoma: Therapeutic targeting of MYCN and ALK.

Barone G, Anderson J, Pearson AD, Petrie K, Chesler L.

Clin Cancer Res. 2013 Nov 1;19(21):5814-21. doi: 10.1158/1078-0432.CCR-13-0680. Epub 2013 Aug 21. Review.


XLID-causing mutations and associated genes challenged in light of data from large-scale human exome sequencing.

Piton A, Redin C, Mandel JL.

Am J Hum Genet. 2013 Aug 8;93(2):368-83. doi: 10.1016/j.ajhg.2013.06.013. Epub 2013 Jul 18. Erratum in: Am J Hum Genet. 2013 Aug 8;93(2):406.


CDK-mediated activation of the SCF(FBXO) (28) ubiquitin ligase promotes MYC-driven transcription and tumourigenesis and predicts poor survival in breast cancer.

Cepeda D, Ng HF, Sharifi HR, Mahmoudi S, Cerrato VS, Fredlund E, Magnusson K, Nilsson H, Malyukova A, Rantala J, Klevebring D, Viñals F, Bhaskaran N, Zakaria SM, Rahmanto AS, Grotegut S, Nielsen ML, Szigyarto CA, Sun D, Lerner M, Navani S, Widschwendter M, Uhlén M, Jirström K, Pontén F, Wohlschlegel J, Grandér D, Spruck C, Larsson LG, Sangfelt O.

EMBO Mol Med. 2013 Jul;5(7):1067-86. doi: 10.1002/emmm.201202341. Epub 2013 Jun 14.


RHPN2 drives mesenchymal transformation in malignant glioma by triggering RhoA activation.

Danussi C, Akavia UD, Niola F, Jovic A, Lasorella A, Pe'er D, Iavarone A.

Cancer Res. 2013 Aug 15;73(16):5140-50. doi: 10.1158/0008-5472.CAN-13-1168-T. Epub 2013 Jun 17.


Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1-mediated down-regulation of p21 and p15.

Inoue S, Hao Z, Elia AJ, Cescon D, Zhou L, Silvester J, Snow B, Harris IS, Sasaki M, Li WY, Itsumi M, Yamamoto K, Ueda T, Dominguez-Brauer C, Gorrini C, Chio II, Haight J, You-Ten A, McCracken S, Wakeham A, Ghazarian D, Penn LJ, Melino G, Mak TW.

Genes Dev. 2013 May 15;27(10):1101-14. doi: 10.1101/gad.214577.113.


A network of substrates of the E3 ubiquitin ligases MDM2 and HUWE1 control apoptosis independently of p53.

Kurokawa M, Kim J, Geradts J, Matsuura K, Liu L, Ran X, Xia W, Ribar TJ, Henao R, Dewhirst MW, Kim WJ, Lucas JE, Wang S, Spector NL, Kornbluth S.

Sci Signal. 2013 May 7;6(274):ra32. doi: 10.1126/scisignal.2003741.

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