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Results: 1 to 20 of 56

1.

Epigenetic-based therapies for Friedreich ataxia.

Sandi C, Sandi M, Anjomani Virmouni S, Al-Mahdawi S, Pook MA.

Front Genet. 2014 Jun 3;5:165. doi: 10.3389/fgene.2014.00165. eCollection 2014. Review.

PMID:
24917884
[PubMed]
Free PMC Article
2.

Rescue of the Friedreich ataxia knockout mutation in transgenic mice containing an FXN-EGFP genomic reporter.

Sarsero JP, Holloway TP, Li L, Finkelstein DI, Ioannou PA.

PLoS One. 2014 Mar 25;9(3):e93307. doi: 10.1371/journal.pone.0093307. eCollection 2014.

PMID:
24667739
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Friedreich's ataxia, frataxin, PIP5K1B: echo of a distant fracas.

Bayot A, Rustin P.

Oxid Med Cell Longev. 2013;2013:725635. doi: 10.1155/2013/725635. Epub 2013 Sep 30. Review.

PMID:
24194977
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Epigenetics of Alzheimer's disease and frontotemporal dementia.

Veerappan CS, Sleiman S, Coppola G.

Neurotherapeutics. 2013 Oct;10(4):709-21. doi: 10.1007/s13311-013-0219-0. Review.

PMID:
24150812
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

A GAA repeat expansion reporter model of Friedreich's ataxia recapitulates the genomic context and allows rapid screening of therapeutic compounds.

Lufino MM, Silva AM, Németh AH, Alegre-Abarrategui J, Russell AJ, Wade-Martins R.

Hum Mol Genet. 2013 Dec 20;22(25):5173-87. doi: 10.1093/hmg/ddt370. Epub 2013 Aug 13.

PMID:
23943791
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

HDAC3 is essential for DNA replication in hematopoietic progenitor cells.

Summers AR, Fischer MA, Stengel KR, Zhao Y, Kaiser JF, Wells CE, Hunt A, Bhaskara S, Luzwick JW, Sampathi S, Chen X, Thompson MA, Cortez D, Hiebert SW.

J Clin Invest. 2013 Jul 1;123(7):3112-23. doi: 10.1172/JCI60806. Epub 2013 Jun 10.

PMID:
23921131
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Increasing frataxin gene expression with histone deacetylase inhibitors as a therapeutic approach for Friedreich's ataxia.

Gottesfeld JM, Rusche JR, Pandolfo M.

J Neurochem. 2013 Aug;126 Suppl 1:147-54. doi: 10.1111/jnc.12302. Review.

PMID:
23859350
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Development of frataxin gene expression measures for the evaluation of experimental treatments in Friedreich's ataxia.

Plasterer HL, Deutsch EC, Belmonte M, Egan E, Lynch DR, Rusche JR.

PLoS One. 2013 May 17;8(5):e63958. doi: 10.1371/journal.pone.0063958. Print 2013.

PMID:
23691127
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Epigenetics in Friedreich's Ataxia: Challenges and Opportunities for Therapy.

Sandi C, Al-Mahdawi S, Pook MA.

Genet Res Int. 2013;2013:852080. doi: 10.1155/2013/852080. Epub 2013 Feb 19.

PMID:
23533785
[PubMed]
Free PMC Article
10.

Pharmacological screening using an FXN-EGFP cellular genomic reporter assay for the therapy of Friedreich ataxia.

Li L, Voullaire L, Sandi C, Pook MA, Ioannou PA, Delatycki MB, Sarsero JP.

PLoS One. 2013;8(2):e55940. doi: 10.1371/journal.pone.0055940. Epub 2013 Feb 13.

PMID:
23418481
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

MLL histone methylases regulate expression of HDLR-SR-B1 in presence of estrogen and control plasma cholesterol in vivo.

Ansari KI, Kasiri S, Hussain I, Bobzean SA, Perrotti LI, Mandal SS.

Mol Endocrinol. 2013 Jan;27(1):92-105. doi: 10.1210/me.2012-1147. Epub 2012 Nov 28.

PMID:
23192982
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Novel frataxin isoforms may contribute to the pathological mechanism of Friedreich ataxia.

Xia H, Cao Y, Dai X, Marelja Z, Zhou D, Mo R, Al-Mahdawi S, Pook MA, Leimkühler S, Rouault TA, Li K.

PLoS One. 2012;7(10):e47847. doi: 10.1371/journal.pone.0047847. Epub 2012 Oct 17.

PMID:
23082224
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Oral administration of the pimelic diphenylamide HDAC inhibitor HDACi 4b is unsuitable for chronic inhibition of HDAC activity in the CNS in vivo.

Beconi M, Aziz O, Matthews K, Moumné L, O'Connell C, Yates D, Clifton S, Pett H, Vann J, Crowley L, Haughan AF, Smith DL, Woodman B, Bates GP, Brookfield F, Bürli RW, McAllister G, Dominguez C, Munoz-Sanjuan I, Beaumont V.

PLoS One. 2012;7(9):e44498. doi: 10.1371/journal.pone.0044498. Epub 2012 Sep 4.

PMID:
22973455
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Childhood ataxia: clinical features, pathogenesis, key unanswered questions, and future directions.

Ashley CN, Hoang KD, Lynch DR, Perlman SL, Maria BL.

J Child Neurol. 2012 Sep;27(9):1095-120. doi: 10.1177/0883073812448840. Epub 2012 Aug 1.

PMID:
22859693
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Genome-wide histone acetylation is altered in a transgenic mouse model of Huntington's disease.

McFarland KN, Das S, Sun TT, Leyfer D, Xia E, Sangrey GR, Kuhn A, Luthi-Carter R, Clark TW, Sadri-Vakili G, Cha JH.

PLoS One. 2012;7(7):e41423. doi: 10.1371/journal.pone.0041423. Epub 2012 Jul 27.

PMID:
22848491
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Therapeutic developments in Friedreich ataxia.

Wilson RB.

J Child Neurol. 2012 Sep;27(9):1212-6. doi: 10.1177/0883073812449691. Epub 2012 Jul 12. Review.

PMID:
22791549
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Rationale for the development of 2-aminobenzamide histone deacetylase inhibitors as therapeutics for Friedreich ataxia.

Soragni E, Xu C, Plasterer HL, Jacques V, Rusche JR, Gottesfeld JM.

J Child Neurol. 2012 Sep;27(9):1164-73. doi: 10.1177/0883073812448533. Epub 2012 Jul 4. Review.

PMID:
22764181
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Is Friedreich ataxia an epigenetic disorder?

Kumari D, Usdin K.

Clin Epigenetics. 2012 Jan 30;4(1):2. doi: 10.1186/1868-7083-4-2.

PMID:
22414340
[PubMed]
Free PMC Article
19.

Inhibition of the function of class IIa HDACs by blocking their interaction with MEF2.

Jayathilaka N, Han A, Gaffney KJ, Dey R, Jarusiewicz JA, Noridomi K, Philips MA, Lei X, He J, Ye J, Gao T, Petasis NA, Chen L.

Nucleic Acids Res. 2012 Jul;40(12):5378-88. doi: 10.1093/nar/gks189. Epub 2012 Mar 6.

PMID:
22396528
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Epigenetics in nucleotide repeat expansion disorders.

He F, Todd PK.

Semin Neurol. 2011 Nov;31(5):470-83. doi: 10.1055/s-0031-1299786. Epub 2012 Jan 21. Review.

PMID:
22266885
[PubMed - indexed for MEDLINE]
Free PMC Article

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