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Results: 1 to 20 of 88

for (Select 18385378)

1.

Disturbed calcium signaling in spinocerebellar ataxias and Alzheimer's disease.

Egorova P, Popugaeva E, Bezprozvanny I.

Semin Cell Dev Biol. 2015 Apr;40:127-133. doi: 10.1016/j.semcdb.2015.03.010. Epub 2015 Apr 4. Review.

PMID:
25846864
2.

Neurobehavioral Differences Between Mice Receiving Distinct Neuregulin Variants as Neonates; Impact on Sensitivity to MK-801.

Kato T, Abe Y, Hirokawa S, Iwakura Y, Mizuno M, Namba H, Nawa H.

Curr Mol Med. 2015;15(3):222-36.

3.

BACE1 inhibitor drugs in clinical trials for Alzheimer's disease.

Vassar R.

Alzheimers Res Ther. 2014 Dec 24;6(9):89. doi: 10.1186/s13195-014-0089-7. eCollection 2014.

4.

An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease.

Kizuka Y, Kitazume S, Fujinawa R, Saito T, Iwata N, Saido TC, Nakano M, Yamaguchi Y, Hashimoto Y, Staufenbiel M, Hatsuta H, Murayama S, Manya H, Endo T, Taniguchi N.

EMBO Mol Med. 2015 Jan 15;7(2):175-89. doi: 10.15252/emmm.201404438.

5.

Aβ reduction in BACE1 heterozygous null 5XFAD mice is associated with transgenic APP level.

Sadleir KR, Eimer WA, Cole SL, Vassar R.

Mol Neurodegener. 2015 Jan 7;10:1. doi: 10.1186/1750-1326-10-1.

6.

Neuregulin-ERBB signaling in the nervous system and neuropsychiatric diseases.

Mei L, Nave KA.

Neuron. 2014 Jul 2;83(1):27-49. doi: 10.1016/j.neuron.2014.06.007. Review.

8.

The normal and pathologic roles of the Alzheimer's β-secretase, BACE1.

Kandalepas PC, Vassar R.

Curr Alzheimer Res. 2014;11(5):441-9. Review.

9.

Genetics and smoking.

Loukola A, Hällfors J, Korhonen T, Kaprio J.

Curr Addict Rep. 2014 Mar 1;1(1):75-82.

10.

BACE1 (β-secretase) inhibitors for the treatment of Alzheimer's disease.

Ghosh AK, Osswald HL.

Chem Soc Rev. 2014 Oct 7;43(19):6765-813. doi: 10.1039/c3cs60460h. Review.

PMID:
24691405
11.

Targeted deletion of the C-terminus of the mouse adenomatous polyposis coli tumor suppressor results in neurologic phenotypes related to schizophrenia.

Onouchi T, Kobayashi K, Sakai K, Shimomura A, Smits R, Sumi-Ichinose C, Kurosumi M, Takao K, Nomura R, Iizuka-Kogo A, Suzuki H, Kondo K, Akiyama T, Miyakawa T, Fodde R, Senda T.

Mol Brain. 2014 Mar 29;7:21. doi: 10.1186/1756-6606-7-21.

12.

Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects.

Vassar R, Kuhn PH, Haass C, Kennedy ME, Rajendran L, Wong PC, Lichtenthaler SF.

J Neurochem. 2014 Jul;130(1):4-28. doi: 10.1111/jnc.12715. Epub 2014 Apr 19. Review.

13.

Postsynaptic target specific synaptic dysfunctions in the CA3 area of BACE1 knockout mice.

Wang H, Megill A, Wong PC, Kirkwood A, Lee HK.

PLoS One. 2014 Mar 17;9(3):e92279. doi: 10.1371/journal.pone.0092279. eCollection 2014.

14.

Targeting the β secretase BACE1 for Alzheimer's disease therapy.

Yan R, Vassar R.

Lancet Neurol. 2014 Mar;13(3):319-29. doi: 10.1016/S1474-4422(13)70276-X. Epub 2014 Feb 17. Review.

15.

Reversible overexpression of bace1-cleaved neuregulin-1 N-terminal fragment induces schizophrenia-like phenotypes in mice.

Luo X, He W, Hu X, Yan R.

Biol Psychiatry. 2014 Jul 15;76(2):120-7. doi: 10.1016/j.biopsych.2013.09.026. Epub 2013 Oct 5.

PMID:
24210810
16.

Substrate ectodomain is critical for substrate preference and inhibition of γ-secretase.

Funamoto S, Sasaki T, Ishihara S, Nobuhara M, Nakano M, Watanabe-Takahashi M, Saito T, Kakuda N, Miyasaka T, Nishikawa K, Saido TC, Ihara Y.

Nat Commun. 2013;4:2529. doi: 10.1038/ncomms3529.

17.

Can BACE1 inhibition mitigate early axonal pathology in neurological diseases?

Yan XX, Ma C, Gai WP, Cai H, Luo XG.

J Alzheimers Dis. 2014;38(4):705-18. doi: 10.3233/JAD-131400. Review.

18.

ΔFosB induction in prefrontal cortex by antipsychotic drugs is associated with negative behavioral outcomes.

Dietz DM, Kennedy PJ, Sun H, Maze I, Gancarz AM, Vialou V, Koo JW, Mouzon E, Ghose S, Tamminga CA, Nestler EJ.

Neuropsychopharmacology. 2014 Feb;39(3):538-44. doi: 10.1038/npp.2013.255. Epub 2013 Sep 26.

19.

Mechanisms that lessen benefits of β-secretase reduction in a mouse model of Alzheimer's disease.

Devi L, Ohno M.

Transl Psychiatry. 2013 Jul 23;3:e284. doi: 10.1038/tp.2013.59.

20.

BACE1 regulates hippocampal astrogenesis via the Jagged1-Notch pathway.

Hu X, He W, Luo X, Tsubota KE, Yan R.

Cell Rep. 2013 Jul 11;4(1):40-9. doi: 10.1016/j.celrep.2013.06.005. Epub 2013 Jul 3.

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